Search Results - "Tite, John P."

Safe and stable generation of induced pluripotent stem cells using doggybone DNA vectors by Thornton, Christopher D., Fielding, Stuart, Karbowniczek, Kinga, Roig-Merino, Alicia, Burrows, Alysha E., FitzPatrick, Lorna M., Sharaireh, Aseel, Tite, John P., Mole, Sara E., Harbottle, Richard P., Caproni, Lisa J., McKay, Tristan R.

“…The application of induced pluripotent stem cells (iPSCs) in advanced therapies is increasing at pace, but concerns remain over their clinical safety profile…”
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Production of lentiviral vectors using novel, enzymatically produced, linear DNA by Karda, Rajvinder, Counsell, John R., Karbowniczek, Kinga, Caproni, Lisa J., Tite, John P., Waddington, Simon N.

“…The manufacture of large quantities of high-quality DNA is a major bottleneck in the production of viral vectors for gene therapy. Touchlight Genetics has…”
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Linear doggybone DNA vaccine induces similar immunological responses to conventional plasmid DNA independently of immune recognition by TLR9 in a pre-clinical model by Allen, Alex, Wang, Chuan, Caproni, Lisa J., Sugiyarto, Gessa, Harden, Elena, Douglas, Leon R., Duriez, Patrick J., Karbowniczek, Kinga, Extance, Jon, Rothwell, Paul J., Orefo, Ifeayinwa, Tite, John P., Stevenson, Freda K., Ottensmeier, Christian H., Savelyeva, Natalia

“…Vaccination with DNA that encodes cancer antigens is a simple and convenient way to raise immunity against cancer and has already shown promise in the clinical…”
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Instruction of naive CD4+ T cells by polarized CD4+ T cells within dendritic cell clusters by Creusot, Rémi J., Biswas, Jason S., Thomsen, Lindy L., Tite, John P., Mitchison, N. Avrion, Chain, Benjamin M.

“…Cooperation between CD4+ T cells can enhance the response and modulate the cytokine profile, and defining these parameters has become a major issue for…”
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Cross-linking of the CAMPATH-1 antigen (CD52) triggers activation of normal human T lymphocytes by Rowan, W C, Hale, G, Tite, J P, Brett, S J

“…The CAMPATH-1 (CD52) antigen is a 21-28 kDa glycopeptide which is highly expressed on lymphocytes and macrophages and is coupled to the membrane by a…”
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Imiquimod and resiquimod in a mouse model: adjuvants for DNA vaccination by particle-mediated immunotherapeutic delivery by Thomsen, Lindy L., Topley, Peter, Daly, Maria G., Brett, Sara J., Tite, John P.

“…Imiquimod, an immune response modifier and inducer of cytokines in vitro and in vivo, has been shown to have potent antiviral and antitumour activity and to…”
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Galactose Oxidation in the Design of Immunogenic Vaccines by Zheng, Biao, Brett, Sara J., Tite, John P., Lifely, M. Robert, Brodie, Thomas A., Rhodes, John

“…Potent immunological adjuvants are urgently required to complement recombinant and synthetic vaccines. However, it has not been possible to derive new…”
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Characterization of CC‐chemokine receptor 7 expression on murine T cells in lymphoid tissues by Bjorkdahl, Olle, Barber, Karen A., Brett, Sara J., Daly, Maria G., Plumpton, Christopher, Elshourbagy, Nabil A., Tite, John P., Thomsen, Lindy L.

“…Summary Expression of the lymph node homing and CC‐chemokine receptor 7 (CCR7), with L‐selectin (CD62L), has been shown to divide human memory T cells into two…”
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Local Cooperation Dominates Over Competition Between CD4+ T Cells of Different Antigen/MHC Specificity by Creusot, Remi J, Thomsen, Lindy L, Tite, John P, Chain, Benjamin M

“…Interactions between CD4(+) T cells in vivo are controlled by a balance between cooperation and competition. In this study the interaction between two…”
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Expression of L-Selectin on Th1 Cells Is Regulated by IL-12 by Wely, Cathy A. van, Beverley, Peter C. L, Brett, Sara J, Britten, Christopher J, Tite, John P

“…L-selectin has become established as a key molecule in the recirculation of naïve T cells from the blood to peripheral lymph nodes, yet little is known about…”
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Early commitment of adoptively transferred CD4 + T cells following particle-mediated DNA vaccination: implications for the study of immunomodulation by Creusot, Rémi J., Thomsen, Lindy L., van Wely, Cathy A., Topley, Peter, Tite, John P., Chain, Benjamin M.

“…The early responses of CD4 + T cells to particle-mediated DNA immunisation were investigated using OVA-specific TCR-transgenic CD4 + T cells. Following…”
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Imiquimod and resiquimod in a mouse model: adjuvants for DNA vaccination by particle-mediated immunotherapeutic delivery: DNA vaccines: research frontiers and clinical applications by THOMSEN, Lindy L, TOPLEY, Peter, DALY, Maria G, BRETT, Sara J, TITE, John P

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The involvement of tumor necrosis factor in immunity to Salmonella infection by Tite, JP, Dougan, G, Chatfield, SN

“…The role of TNF in immunity to Salmonella in mice was studied. Antiserum specific for murine TNF was raised and used to neutralize TNF activity in vivo…”
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DNA Fragmentation: Manifestation of Target Cell Destruction Mediated by Cytotoxic T-Cell Lines, Lymphotoxin-Secreting Helper T-Cell Clones, and Cell-Free Lymphotoxin-Containing Supernatant by Schmid, D. Scott, Tite, John P., Ruddle, Nancy H.

“…A Lyt-2+, trinitrophenyl-specific, lymphotoxin-secreting, cytotoxic T-cell line, PCl 55, mediates the digestion of target cell DNA into discretely sized…”
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Identification of T- and B-cell epitopes of the E7 protein of human papillomavirus type 16 by COMERFORD, S. A, MCCANCE, D. J, DOUGAN, G, TITE, J. P

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Cloned helper T cells can kill B lymphoma cells in the presence of specific antigen: Ia restriction and cognate vs. noncognate interactions in cytolysis by Tite, J P, Janeway, Jr, C A

“…Cloned, Lyt-1+,2-, antigen-specific, Ia-restricted T cell lines can inhibit the growth of Ia-bearing B lymphoma cells in the presence of specific antigen. This…”
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The detection and enumeration of cytokine-secreting cells in mice and man and the clinical application of these assays by Hutchings, P R, Cambridge, G, Tite, J P, Meager, T, Cooke, A

“…An in vitro assay for the detection and enumeration of mouse and human cytokine-secreting cells is described and some ways in which it may be used…”
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Human T cell recognition of influenza A nucleoprotein. Specificity and genetic restriction of immunodominant T helper cell epitopes by Brett, SJ, Blau, J, Hughes-Jenkins, CM, Rhodes, J, Liew, FY, Tite, JP

“…The characterization of human T cell antigenic sites on influenza A nucleoprotein (NP) is important for subunit vaccine development for either antibody…”
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Comparison of antigen presentation of influenza A nucleoprotein expressed in attenuated AroA- Salmonella typhimurium with that of live virus by Brett, SJ, Rhodes, J, Liew, FY, Tite, JP

“…Rationally attenuated strains of Salmonella expressing foreign proteins represent a potentially important vaccine delivery system. The characteristics of Ag…”
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The role of B cell surface Ia antigen recognition by T cells in B cell triggering. Analysis of the interaction of cloned helper T cells with normal B cells in differing states of activation and with B cells expressing the xid defect by Tite, J P, Kaye, J, Jones, B

“…Two discrete mechanisms of T-B cell collaboration appear to exist. In cognate recognition, B cell triggering results from a direct recognition of antigen and…”
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