Search Results - "Tischner, Denise"

G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators by Gurusamy, Malarvizhi, Tischner, Denise, Shao, Jingchen, Klatt, Stephan, Zukunft, Sven, Bonnavion, Remy, Günther, Stefan, Siebenbrodt, Kai, Kestner, Roxane-Isabelle, Kuhlmann, Tanja, Fleming, Ingrid, Offermanns, Stefan, Wettschureck, Nina

“…G-protein-coupled receptors (GPCRs), especially chemokine receptors, play a central role in the regulation of T cell migration. Various GPCRs are upregulated…”
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EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells by Wanke, Florian, Moos, Sonja, Croxford, Andrew L., Heinen, André P., Gräf, Stephanie, Kalt, Bettina, Tischner, Denise, Zhang, Juan, Christen, Isabelle, Bruttger, Julia, Yogev, Nir, Tang, Yilang, Zayoud, Morad, Israel, Nicole, Karram, Khalad, Reißig, Sonja, Lacher, Sonja M., Reichhold, Christian, Mufazalov, Ilgiz A., Ben-Nun, Avraham, Kuhlmann, Tanja, Wettschureck, Nina, Sailer, Andreas W., Rajewsky, Klaus, Casola, Stefano, Waisman, Ari, Kurschus, Florian C.

“…Arrival of encephalitogenic T cells at inflammatory foci represents a critical step in development of experimental autoimmune encephalomyelitis (EAE), the…”
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Glucocorticoid Receptor-Deficient Foxp3 + Regulatory T Cells Fail to Control Experimental Inflammatory Bowel Disease by Rocamora-Reverte, Lourdes, Tuzlak, Selma, von Raffay, Laura, Tisch, Marcel, Fiegl, Heidi, Drach, Mathias, Reichardt, Holger M, Villunger, Andreas, Tischner, Denise, Wiegers, G Jan

“…Activation of the immune system increases systemic adrenal-derived glucocorticoid (GC) levels which downregulate the immune response as part of a negative…”
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Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice by Ottina, Eleonora, Grespi, Francesca, Tischner, Denise, Soratroi, Claudia, Geley, Stephan, Ploner, Andreas, Reichardt, Holger M., Villunger, Andreas, Herold, Marco J.

“…Gene-targeting studies in mice have identified the essential roles of most prosurvival Bcl-2 family members in normal physiology and under conditions of…”
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Therapeutic and adverse effects of a non-steroidal glucocorticoid receptor ligand in a mouse model of multiple sclerosis by Wüst, Simone, Tischner, Denise, John, Michael, Tuckermann, Jan P, Menzfeld, Christiane, Hanisch, Uwe-Karsten, van den Brandt, Jens, Lühder, Fred, Reichardt, Holger M

“…Dissociating glucocorticoid receptor (GR) ligands hold great promise for treating inflammatory disorders since it is assumed that they exert beneficial…”
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Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism by Menzfeld, Christiane, John, Michael, van Rossum, Denise, Regen, Tommy, Scheffel, Jörg, Janova, Hana, Götz, Alexander, Ribes, Sandra, Nau, Roland, Borisch, Angela, Boutin, Philippe, Neumann, Konstantin, Bremes, Vanessa, Wienands, Jürgen, Reichardt, Holger M., Lühder, Fred, Tischner, Denise, Waetzig, Vicky, Herdegen, Thomas, Teismann, Peter, Greig, Iain, Müller, Michael, Pukrop, Tobias, Mildner, Alexander, Kettenmann, Helmut, Brück, Wolfgang, Prinz, Marco, Rotshenker, Shlomo, Weber, Martin S., Hanisch, Uwe-Karsten

“…The putative protein tyrosine kinase (PTK) inhibitor tyrphostin AG126 has proven beneficial in various models of inflammatory disease. Yet molecular targets…”
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Haematopoietic stem cell survival and transplantation efficacy is limited by the BH3‐only proteins Bim and Bmf by Labi, Verena, Bertele, Daniela, Woess, Claudia, Tischner, Denise, Bock, Florian J., Schwemmers, Sven, Pahl, Heike L., Geley, Stephan, Kunze, Mirjam, Niemeyer, Charlotte M., Villunger, Andreas, Erlacher, Miriam

“…Anti‐apoptotic Bcl‐2 family members are critical for the regulation of haematopoietic stem and progenitor cell (HSPC) survival. Little is known about the role…”
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Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation by Tischner, Denise, Grimm, Myriam, Kaur, Harmandeep, Staudenraus, Daniel, Carvalho, Jorge, Looso, Mario, Günther, Stefan, Wanke, Florian, Moos, Sonja, Siller, Nelly, Breuer, Johanna, Schwab, Nicholas, Zipp, Frauke, Waisman, Ari, Kurschus, Florian C., Offermanns, Stefan, Wettschureck, Nina

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Necrosis-like death can engage multiple pro-apoptotic Bcl-2 protein family members by Tischner, Denise, Manzl, Claudia, Soratroi, Claudia, Villunger, Andreas, Krumschnabel, Gerhard

“…Necroptosis is a physiologically relevant mode of cell death with some well-described initiating events, but largely unknown executioners. Here we investigated…”
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A1/Bfl-1 in leukocyte development and cell death by Ottina, Eleonora, Tischner, Denise, Herold, Marco J., Villunger, Andreas

“…The function of the anti-apoptotic Bcl-2 family member Bcl2a1/Bfl-1/A1 is poorly understood due to the lack of appropriate loss-of-function mouse models and…”
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Glucocorticoids in the control of neuroinflammation by Tischner, Denise, Reichardt, Holger M.

“…Glucocorticoids are a class of steroid hormones that are endowed with profound anti-inflammatory and immunosuppressive activities. Endogenous glucocorticoids…”
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Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis by Sivaraj, Kishor K, Li, Rui, Albarran-Juarez, Julian, Wang, Shengpeng, Tischner, Denise, Grimm, Myriam, Swiercz, Jakub M, Offermanns, Stefan, Wettschureck, Nina

“…VEGF A (VEGF-A) is a central regulator of pre- and postnatal vascular development. In vitro studies suggested that heterotrimeric G-proteins of the Gq/11…”
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Peripheral T Cells Are the Therapeutic Targets of Glucocorticoids in Experimental Autoimmune Encephalomyelitis by Wust, Simone, van den Brandt, Jens, Tischner, Denise, Kleiman, Anna, Tuckermann, Jan P, Gold, Ralf, Luhder, Fred, Reichardt, Holger M

“…High-dose glucocorticoid (GC) therapy is widely used to treat multiple sclerosis (MS), but the underlying mechanisms remain debatable. In this study, we…”
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PINCH-1 promotes Bcl-2-dependent survival signalling and inhibits JNK-mediated apoptosis in the primitive endoderm by Montanez, Eloi, Karaköse, Esra, Tischner, Denise, Villunger, Andreas, Fässler, Reinhard

“…The focal adhesion (FA) protein PINCH-1 is required for the survival of primitive endoderm (PrE) cells. How PINCH-1 regulates this fundamental process is not…”
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PINCH-1 promotes Bcl-2-dependent survival signalling and inhibits JNK-mediated apoptosis in the primitive endoderm by Montanez, Eloi, Karaköse, Esra, Tischner, Denise, Villunger, Andreas, Fässler, Reinhard

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Glucocorticoids induce effector T cell depolarization via ERM proteins, thereby impeding migration and APC conjugation by Müller, Nora, Fischer, Henrike J, Tischner, Denise, van den Brandt, Jens, Reichardt, Holger M

“…Glucocorticoids (GCs) repress lymphocyte function by controlling gene expression. In this study, we investigated Ag-specific effector T cells and provide…”
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Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice by Tischner, Denise, Gaggl, Irene, Peschel, Ines, Kaufmann, Manuel, Tuzlak, Selma, Drach, Mathias, Thuille, Nikolaus, Villunger, Andreas, Jan Wiegers, G

“…Abstract The Bcl-2 regulated apoptosis pathway is critical for the elimination of autoreactive lymphocytes, thereby precluding autoimmunity. T cells escaping…”
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Shaping the T-cell repertoire: a matter of life and death by Wiegers, G Jan, Kaufmann, Manuel, Tischner, Denise, Villunger, Andreas

“…Thymocyte selection aims to shape a T‐cell repertoire that, on the one hand, is able to recognize and respond to foreign peptides and, on the other hand,…”
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S1P 2 /G 12/13 Signaling Negatively Regulates Macrophage Activation and Indirectly Shapes the Atheroprotective B1-Cell Population by Grimm, Myriam, Tischner, Denise, Troidl, Kerstin, Albarrán Juárez, Julián, Sivaraj, Kishor K., Ferreirós Bouzas, Nerea, Geisslinger, Gerd, Binder, Christoph J., Wettschureck, Nina

“…Objectives— Monocyte/macrophage recruitment and activation at vascular predilection sites plays a central role in the pathogenesis of atherosclerosis…”
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Acid sphingomyelinase is required for protection of effector memory T cells against glucocorticoid-induced cell death by Tischner, Denise, Theiss, Jennifer, Karabinskaya, Anna, van den Brandt, Jens, Reichardt, Sybille D, Karow, Ulrike, Herold, Marco J, Lühder, Fred, Utermöhlen, Olaf, Reichardt, Holger M

“…The activity of acid sphingomyelinase (aSMase) was previously reported to be involved in glucocorticoid-induced cell death (GICD) of T lymphocytes. This…”
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