Search Results - "Tisch, R."

Evidence for the role of EPHX2 gene variants in anorexia nervosa by Scott-Van Zeeland, A A, Bloss, C S, Tewhey, R, Bansal, V, Torkamani, A, Libiger, O, Duvvuri, V, Wineinger, N, Galvez, L, Darst, B F, Smith, E N, Carson, A, Pham, P, Phillips, T, Villarasa, N, Tisch, R, Zhang, G, Levy, S, Murray, S, Chen, W, Srinivasan, S, Berenson, G, Brandt, H, Crawford, S, Crow, S, Fichter, M M, Halmi, K A, Johnson, C, Kaplan, A S, La Via, M, Mitchell, J E, Strober, M, Rotondo, A, Treasure, J, Woodside, D B, Bulik, C M, Keel, P, Klump, K L, Lilenfeld, L, Plotnicov, K, Topol, E J, Shih, P B, Magistretti, P, Bergen, A W, Berrettini, W, Kaye, W, Schork, N J

“…Anorexia nervosa (AN) and related eating disorders are complex, multifactorial neuropsychiatric conditions with likely rare and common genetic and…”
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Elevated NF-κB Activation in Nonobese Diabetic Mouse Dendritic Cells Results in Enhanced APC Function by Poligone, Brian, Weaver, Donald J., Sen, Pradip, Baldwin, Albert S., Tisch, Roland

“…Abstract We have recently demonstrated that dendritic cells (DC) prepared from nonobese diabetic (NOD) mice, a spontaneous model for insulin-dependent diabetes…”
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Dysrulation of T cell peripheral tolerance in type 1 diabetes by Tisch, R, Wang, B

“…Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease in which the insulin producing beta cells are destroyed. The breakdown of beta cell-specific…”
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CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice by Balasa, B, Krahl, T, Patstone, G, Lee, J, Tisch, R, McDevitt, HO, Sarvetnick, N

“…The nonobese diabetic (NOD) mouse spontaneously develops T cell-dependent autoimmune diabetes. Here, we investigate the role of CD40 ligand (CD40L)-CD40…”
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Dendritic cells from nonobese diabetic mice exhibit a defect in NF-kappa B regulation due to a hyperactive I kappa B kinase by Weaver, Jr, D J, Poligone, B, Bui, T, Abdel-Motal, U M, Baldwin, Jr, A S, Tisch, R

“…Insulin-dependent diabetes mellitus (IDDM) is characterized by the T cell-mediated destruction of insulin-producing beta cells. Accordingly, APCs, such as…”
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Antigen-specific mediated suppression of beta cell autoimmunity by plasmid DNA vaccination by Tisch, R, Wang, B, Weaver, D J, Liu, B, Bui, T, Arthos, J, Serreze, D V

“…In this study, we have investigated the use of plasmid DNA (pDNA) vaccination to elicit Th2 effector cell function in an Ag-specific manner and in turn prevent…”
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B Lymphocytes Are Critical Antigen-Presenting Cells for the Initiation of T Cell-Mediated Autoimmune Diabetes in Nonobese Diabetic Mice by Serreze, David V, Fleming, Sara A, Chapman, Harold D, Richard, Scott D, Leiter, Edward H, Tisch, Roland M

“…Nonobese diabetic (NOD) mice genetically deficient in B lymphocytes (NODJg mu(null)) are resistant to T cell-mediated autoimmune insulin-dependent diabetes…”
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Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice by TISCH, R, LIBLAU, R. S, YANG, X.-D, LIBLAU, P, MCDEVITT, H. O

“…Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice. R Tisch , R S Liblau , X D Yang , P Liblau and H…”
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The receptor tyrosine kinase MerTK regulates dendritic cell production of BAFF by Gohlke, P. R., Williams, J. C., Vilen, B. J., Dillon, S. R., Tisch, R., Matsushima, G. K.

“…The MerTK receptor tyrosine kinase is an important negative regulator of dendritic cell function and is required to prevent B cell autoimmunity in vivo. It is…”
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Effect of tumor necrosis factor α on insulin-dependent diabetes mellitus in NOD mice. I: The early development of autoimmunity and the diabetogenic process by XIAO-DONG YANG, TISCH, R, SINGER, S. M, CAO, Z. A, LIBLAU, R. S, SCHREIBER, R. D, MCDEVITT, H. O

“…Tumor necrosis factor (TNF) alpha is a cytokine that has potent immune regulatory functions. To assess the potential role of this cytokine in the early…”
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Plasmid DNAs Encoding Insulin and Glutamic Acid Decarboxylase 65 Have Distinct Effects on the Progression of Autoimmune Diabetes in Nonobese Diabetic Mice by Weaver, Donald J., Jr, Liu, Bo, Tisch, Roland

“…We previously demonstrated that administration of plasmid DNAs (pDNAs) encoding IL-4 and a fragment of glutamic acid decarboxylase 65 (GAD65) fused to IgGFc…”
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Structural and Photophysical Properties of Visible- and Near-IR-Emitting Tris Lanthanide(III) Complexes Formed with the Enantiomers of N,N′-Bis(1-phenylethyl)-2,6-pyridinedicarboxamide by Hua, KimNgan T, Xu, Jide, Quiroz, Eliseo E, Lopez, Sabrina, Ingram, Andrew J, Johnson, Victoria Anne, Tisch, Angela R, de Bettencourt-Dias, Ana, Straus, Daniel A, Muller, Gilles

“…The enantiomers of N,N′-bis­(1-phenylethyl)-2,6-pyridinedicarboxamide (L), namely, (R,R)-1, and (S,S)-1, react with LnIII ions to give stable [LnL 3]3+…”
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The preferential ability of B lymphocytes to act as diabetogenic APC in NOD mice depends on expression of self‐antigen‐specific immunoglobulin receptors by Silveira, Pablo A., Johnson, Ellis, Chapman, Harold D., Bui, Thi, Tisch, Roland M., Serreze, David V.

“…B lymphocytes partially contribute to autoimmune type 1 diabetes (T1D) as a subset of APC with a preferential ability to trigger pathogenic CD4 T cells. We…”
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Inhibition of Insulitis and Prevention of Diabetes in Nonobese Diabetic Mice by Blocking L-Selectin and Very Late Antigen 4 Adhesion Receptors by Yang, Xiao-Dong, Karin, Nathan, Tisch, Roland, Steinman, Lawrence, McDevitt, Hugh O.

“…Leukocyte adhesion to the endothelial venules in the pancreatic islets is thought to be one of the initial steps in the development of insulin-dependent…”
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The role of cell adhesion molecules in the development of IDDM: implications for pathogenesis and therapy by Yang, X. D., Michie, S. A., Mebius, R. E., Tisch, R., Weissman, I., McDevitt, H. O.

“…The role of cell adhesion molecules in the development of IDDM: implications for pathogenesis and therapy. X D Yang , S A Michie , R E Mebius , R Tisch , I…”
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The Role of Environmental Factors in Insulin-Dependent Diabetes Mellitus: An Unresolved Issue by Kraine, Meredith R., Tisch, Roland M.

“…Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease characterized by the destruction of the insulin-secreting β cells found in the islets of…”
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Prevention of diabetes in NOD mice by a mutated I-Ab transgene by SINGER, S. M, TISCH, R, YANG, X.-D, SYTWU, H.-K, LIBLAU, R, MCDEVITT, H. O

“…Prevention of diabetes in NOD mice by a mutated I-Ab transgene. S M Singer , R Tisch , X D Yang , H K Sytwu , R Liblau and H O McDevitt Department of…”
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T Cell Activity After Dendritic Cell Vaccination Is Dependent on Both the Type of Antigen and the Mode of Delivery by Serody, Jonathan S, Collins2, Edward J, Tisch, Roland M, Kuhns, Jennifer J, Frelinger, Jeffrey A

“…Previous work in both human and animal models has shown that CTL responses can be generated against proteins derived from tumors using either peptide-pulsed…”
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Functional Differences between Immunoglobulins M and D Expressed on the Surface of an Immature B-Cell Line by Tisch, Roland, Roifman, Chaim M., Hozumi, Nobumichi

“…Crosslinked IgM molecules expressed on the surface of immature B cells mediate responses that inhibit further development, in contrast to the activational and…”
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Isolation of nonobese diabetic mouse T-cells that recognize novel autoantigens involved in the early events of diabetes by Gelber, C., Paborsky, L., Singer, S., McAteer, D., Tisch, R., Jolicoeur, C., Buelow, R., McDevitt, H., Fathman, C. G.

“…Isolation of nonobese diabetic mouse T-cells that recognize novel autoantigens involved in the early events of diabetes. C Gelber , L Paborsky , S Singer , D…”
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