Search Results - "Tipton, Christopher"

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus by Jenks, Scott A., Cashman, Kevin S., Zumaquero, Esther, Marigorta, Urko M., Patel, Aakash V., Wang, Xiaoqian, Tomar, Deepak, Woodruff, Matthew C., Simon, Zoe, Bugrovsky, Regina, Blalock, Emily L., Scharer, Christopher D., Tipton, Christopher M., Wei, Chungwen, Lim, S. Sam, Petri, Michelle, Niewold, Timothy B., Anolik, Jennifer H., Gibson, Greg, Lee, F. Eun-Hyung, Boss, Jeremy M., Lund, Frances E., Sanz, Ignacio

“…Systemic Lupus Erythematosus (SLE) is characterized by B cells lacking IgD and CD27 (double negative; DN). We show that DN cell expansions reflected a subset…”
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Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus by Tipton, Christopher M, Fucile, Christopher F, Darce, Jaime, Chida, Asiya, Ichikawa, Travis, Gregoretti, Ivan, Schieferl, Sandra, Hom, Jennifer, Jenks, Scott, Feldman, Ron J, Mehr, Ramit, Wei, Chungwen, Lee, F Eun-Hyung, Cheung, Wan Cheung, Rosenberg, Alexander F, Sanz, Iñaki

“…Patients with systemic lupus erythematosus (SLE) experience flares of autoantibody secretion. Sanz and colleagues track the plasma cell repertoires of patients…”
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Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19 by Woodruff, Matthew C., Ramonell, Richard P., Nguyen, Doan C., Cashman, Kevin S., Saini, Ankur Singh, Haddad, Natalie S., Ley, Ariel M., Kyu, Shuya, Howell, J. Christina, Ozturk, Tugba, Lee, Saeyun, Suryadevara, Naveenchandra, Case, James Brett, Bugrovsky, Regina, Chen, Weirong, Estrada, Jacob, Morrison-Porter, Andrea, Derrico, Andrew, Anam, Fabliha A., Sharma, Monika, Wu, Henry M., Le, Sang N., Jenks, Scott A., Tipton, Christopher M., Staitieh, Bashar, Daiss, John L., Ghosn, Eliver, Diamond, Michael S., Carnahan, Robert H., Crowe, James E., Hu, William T., Lee, F. Eun-Hyung, Sanz, Ignacio

“…A wide spectrum of clinical manifestations has become a hallmark of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 pandemic,…”
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Understanding B‐cell activation and autoantibody repertoire selection in systemic lupus erythematosus: A B‐cell immunomics approach by Tipton, Christopher M., Hom, Jennifer R., Fucile, Christopher F., Rosenberg, Alexander F., Sanz, Inaki

“…Understanding antibody repertoires and in particular, the properties and fates of B cells expressing potentially pathogenic antibodies is critical to define…”
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B-1 plasma cells require non-cognate CD4 T cell help to generate a unique repertoire of natural IgM by Smith, Fauna L, Savage, Hannah P, Luo, Zheng, Tipton, Christopher M, Lee, F Eun-Hyung, Apostol, April C, Beaudin, Anna E, Lopez, Diego A, Jensen, Ingvill, Keller, Stefan, Baumgarth, Nicole

“…Evolutionarily conserved, "natural" (n)IgM is broadly reactive to both self and foreign antigens. Its selective deficiency leads to increases in autoimmune…”
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Long-Lived Plasma Cells Are Contained within the CD19(-)CD38(hi)CD138(+) Subset in Human Bone Marrow by Halliley, Jessica L, Tipton, Christopher M, Liesveld, Jane, Rosenberg, Alexander F, Darce, Jaime, Gregoretti, Ivan V, Popova, Lana, Kaminiski, Denise, Fucile, Christopher F, Albizua, Igor, Kyu, Shuya, Chiang, Kuang-Yueh, Bradley, Kyle T, Burack, Richard, Slifka, Mark, Hammarlund, Erika, Wu, Hao, Zhao, Liping, Walsh, Edward E, Falsey, Ann R, Randall, Troy D, Cheung, Wan Cheung, Sanz, Iñaki, Lee, F Eun-Hyung

“…Antibody responses to viral infections are sustained for decades by long-lived plasma cells (LLPCs). However, LLPCs have yet to be characterized in humans…”
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Exploring the Diversity of the B-Cell Receptor Repertoire Through High-Throughput Sequencing by Hom, Jennifer R, Tomar, Deepak, Tipton, Christopher M

“…Repertoire sequencing of B cells is the high-throughput profiling of B cell receptors (BCR) expressed on the surface of B cells and of immunoglobulins (Ig)…”
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Dysregulated naive B cells and de novo autoreactivity in severe COVID-19 by Woodruff, Matthew C., Ramonell, Richard P., Haddad, Natalie S., Anam, Fabliha A., Rudolph, Mark E., Walker, Tiffany A., Truong, Alexander D., Dixit, Adviteeya N., Han, Jenny E., Cabrera-Mora, Monica, Runnstrom, Martin C., Bugrovsky, Regina, Hom, Jennifer, Connolly, Erin C., Albizua, Igor, Javia, Vidhi, Cashman, Kevin S., Nguyen, Doan C., Kyu, Shuya, Singh Saini, Ankur, Piazza, Michael, Tipton, Christopher M., Khosroshahi, Arezou, Gibson, Greg, Martin, Greg S., Maier, Cheryl L., Esper, Annette, Jenks, Scott A., Lee, F. Eun-Hyung, Sanz, Ignacio

“…Severe SARS-CoV-2 infection 1 has been associated with highly inflammatory immune activation since the earliest days of the COVID-19 pandemic 2 – 5 . More…”
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Malaria-associated atypical memory B cells exhibit markedly reduced B cell receptor signaling and effector function by Portugal, Silvia, Tipton, Christopher M, Sohn, Haewon, Kone, Younoussou, Wang, Jing, Li, Shanping, Skinner, Jeff, Virtaneva, Kimmo, Sturdevant, Daniel E, Porcella, Stephen F, Doumbo, Ogobara K, Doumbo, Safiatou, Kayentao, Kassoum, Ongoiba, Aissata, Traore, Boubacar, Sanz, Inaki, Pierce, Susan K, Crompton, Peter D

“…Protective antibodies in Plasmodium falciparum malaria are only acquired after years of repeated infections. Chronic malaria exposure is associated with a…”
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Understanding and measuring human B‐cell tolerance and its breakdown in autoimmune disease by Cashman, Kevin S., Jenks, Scott A., Woodruff, Matthew C., Tomar, Deepak, Tipton, Christopher M., Scharer, Christopher D., Eun‐Hyung Lee, F., Boss, Jeremy M., Sanz, Iñaki

“…The maintenance of immunological tolerance of B lymphocytes is a complex and critical process that must be implemented as to avoid the detrimental development…”
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Lineage Reconstruction of In Vitro Identified Antigen-Specific Autoreactive B Cells from Adaptive Immune Receptor Repertoires by Blazso, Peter, Csomos, Krisztian, Tipton, Christopher M, Ujhazi, Boglarka, Walter, Jolan E

“…The emergence, survival, growth and maintenance of autoreactive (AR) B-cell clones, the hallmark of humoral autoimmunity, leave their footprints in B-cell…”
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A transcriptionally distinct subset of influenza-specific effector memory B cells predicts long-lived antibody responses to vaccination in humans by Nellore, Anoma, Zumaquero, Esther, Scharer, Christopher D., Fucile, Christopher F., Tipton, Christopher M., King, R. Glenn, Mi, Tian, Mousseau, Betty, Bradley, John E., Zhou, Fen, Mutneja, Stuti, Goepfert, Paul A., Boss, Jeremy M., Randall, Troy D., Sanz, Ignacio, Rosenberg, Alexander F., Lund, Frances E.

“…Seasonal influenza vaccination elicits hemagglutinin (HA)-specific memory B (Bmem) cells, and although multiple Bmem cell populations have been characterized,…”
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Plasmodium falciparum-specific IgM B cells dominate in children, expand with malaria, and produce functional IgM by Hopp, Christine S, Sekar, Padmapriya, Diouf, Ababacar, Miura, Kazutoyo, Boswell, Kristin, Skinner, Jeff, Tipton, Christopher M, Peterson, Mary E, Chambers, Michael J, Andrews, Sarah, Lu, Jinghua, Tan, Joshua, Li, Shanping, Doumbo, Safiatou, Kayentao, Kassoum, Ongoiba, Aissata, Traore, Boubacar, Portugal, Silvia, Sun, Peter D, Long, Carole, Koup, Richard A, Long, Eric O, McDermott, Adrian B, Crompton, Peter D

“…IgG antibodies play a role in malaria immunity, but whether and how IgM protects from malaria and the biology of Plasmodium falciparum (Pf)-specific IgM B…”
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GLaMST: grow lineages along minimum spanning tree for b cell receptor sequencing data by Yang, Xingyu, Tipton, Christopher M, Woodruff, Matthew C, Zhou, Enlu, Lee, F Eun-Hyung, Sanz, Inãki, Qiu, Peng

“…B cell affinity maturation enables B cells to generate high-affinity antibodies. This process involves somatic hypermutation of B cell immunoglobulin receptor…”
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Understanding heterogeneity of human bone marrow plasma cell maturation and survival pathways by single-cell analyses by Duan, Meixue, Nguyen, Doan C., Joyner, Chester J., Saney, Celia L., Tipton, Christopher M., Andrews, Joel, Lonial, Sagar, Kim, Caroline, Hentenaar, Ian, Kosters, Astrid, Ghosn, Eliver, Jackson, Annette, Knechtle, Stuart, Maruthamuthu, Stalinraja, Chandran, Sindhu, Martin, Tom, Rajalingam, Raja, Vincenti, Flavio, Breeden, Cynthia, Sanz, Ignacio, Gibson, Greg, Lee, F. Eun-Hyung

“…Human bone marrow (BM) plasma cells are heterogeneous, ranging from newly arrived antibody-secreting cells (ASCs) to long-lived plasma cells (LLPCs). We…”
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Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosus by Chen, Weirong, Hong, So-Hee, Jenks, Scott A., Anam, Fabliha A., Tipton, Christopher M., Woodruff, Matthew C., Hom, Jennifer R., Cashman, Kevin S., Faliti, Caterina Elisa, Wang, Xiaoqian, Kyu, Shuya, Wei, Chungwen, Scharer, Christopher D., Mi, Tian, Hicks, Sakeenah, Hartson, Louise, Nguyen, Doan C., Khosroshahi, Arezou, Lee, Saeyun, Wang, Youliang, Bugrovsky, Regina, Ishii, Yusho, Lee, F. Eun-Hyung, Sanz, Ignacio

“…Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple autoantibody types, some of which are produced by long-lived plasma cells…”
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Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection by Bohannon, Caitlin, Powers, Ryan, Satyabhama, Lakshmipriyadarshini, Cui, Ang, Tipton, Christopher, Michaeli, Miri, Skountzou, Ioanna, Mittler, Robert S., Kleinstein, Steven H., Mehr, Ramit, Lee, Frances Eun-Yun, Sanz, Ignacio, Jacob, Joshy

“…Long-lived plasma cells are critical to humoral immunity as a lifelong source of protective antibodies. Antigen-activated B cells—with T-cell help—undergo…”
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Somatic Diversification of Rearranged Antibody Gene Segments by Intra- and Interchromosomal Templated Mutagenesis by Dale, Gordon A, Wilkins, Daniel J, Rowley, Jordan, Scharer, Christopher D, Tipton, Christopher M, Hom, Jennifer, Boss, Jeremy M, Corces, Victor, Sanz, Ignacio, Jacob, Joshy

“…The ability of the humoral immune system to generate Abs capable of specifically binding a myriad of Ags is critically dependent on the somatic hypermutation…”
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Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet+ B cells by Csomos, Krisztian, Ujhazi, Boglarka, Blazso, Peter, Herrera, Jose L., Tipton, Christopher M., Kawai, Tomoki, Gordon, Sumai, Ellison, Maryssa, Wu, Kevin, Stowell, Matthew, Haynes, Lauren, Cruz, Rachel, Zakota, Bence, Nguyen, Johnny, Altrich, Michelle, Geier, Christoph B., Sharapova, Svetlana, Dasso, Joseph F., Leiding, Jennifer W., Smith, Grace, Al-Herz, Waleed, de Barros Dorna, Mayra, Fadugba, Olajumoke, Fronkova, Eva, Kanderova, Veronika, Svaton, Michael, Henrickson, Sarah E., Hernandez, Joseph D., Kuijpers, Taco, Kandilarova, Snezhina Mihailova, Naumova, Elizaveta, Milota, Tomas, Sediva, Anna, Moshous, Despina, Neven, Benedicte, Saco, Tara, Sargur, Ravishankar, Savic, Sinisa, Sleasman, John, Sunkersett, Gauri, Ward, Brant R., Komatsu, Masanobu, Pittaluga, Stefania, Kumanovics, Attila, Butte, Manish J., Cancro, Michael P., Pillai, Shiv, Meffre, Eric, Notarangelo, Luigi D., Walter, Jolan E.

“…The recombination-activating genes ( RAG ) 1 and 2 are indispensable for diversifying the primary B cell receptor repertoire and pruning self-reactive clones…”
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Biological controls for standardization and interpretation of adaptive immune receptor repertoire profiling by Trück, Johannes, Eugster, Anne, Barennes, Pierre, Tipton, Christopher M, Luning Prak, Eline T, Bagnara, Davide, Soto, Cinque, Sherkow, Jacob S, Payne, Aimee S, Lefranc, Marie-Paule, Farmer, Andrew, Bostick, Magnolia, Mariotti-Ferrandiz, Encarnita

“…Use of adaptive immune receptor repertoire sequencing (AIRR-seq) has become widespread, providing new insights into the immune system with potential broad…”
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