Search Results - "Tipton, Alycia"

The effects of acute and preventive migraine therapies in a mouse model of chronic migraine by Tipton, Alycia F, Tarash, Igal, McGuire, Brenna, Charles, Andrew, Pradhan, Amynah A

“…Background The development of novel migraine therapies has been slow, in part because of the small number of clinically relevant animal models. We have…”
Get more information

Delta opioid receptor agonists are effective for multiple types of headache disorders by Moye, Laura S., Tipton, Alycia F., Dripps, Isaac, Sheets, Zoie, Crombie, Aimee, Violin, Jonathan D., Pradhan, Amynah A.

“…Headaches are highly disabling and are among the most common neurological disorders worldwide. Despite the high prevalence of headache, therapeutic options are…”
Get full text

Tolerance to high‐internalizing δ opioid receptor agonist is critically mediated by arrestin 2 by Vicente‐Sanchez, Ana, Dripps, Isaac J, Tipton, Alycia F, Akbari, Heba, Akbari, Areeb, Jutkiewicz, Emily M, Pradhan, Amynah A

“…Background and Purpose Opioid δ receptor agonists are potent antihyperalgesics in chronic pain models, but tolerance develops after prolonged use. Previous…”
Get full text

The development of a mouse model of mTBI-induced post-traumatic migraine, and identification of the delta opioid receptor as a novel therapeutic target by Moye, Laura S, Novack, Madeline L, Tipton, Alycia F, Krishnan, Harish, Pandey, Subhash C, Pradhan, Amynah Aa

“…Post-traumatic headache is the most common and long-lasting impairment observed following mild traumatic brain injury, and frequently has migraine-like…”
Get more information

Soluble guanylyl cyclase is a critical regulator of migraine-associated pain by Ben Aissa, Manel, Tipton, Alycia F, Bertels, Zachariah, Gandhi, Ronak, Moye, Laura S, Novack, Madeline, Bennett, Brian M, Wang, Yueting, Litosh, Vladislav, Lee, Sue H, Gaisina, Irina N, Thatcher, Gregory Rj, Pradhan, Amynah A

“…Background Nitric oxide (NO) has been heavily implicated in migraine. Nitroglycerin is a prototypic NO-donor, and triggers migraine in humans. However,…”
Get more information

Forebrain delta opioid receptors regulate the response of delta agonist in models of migraine and opioid-induced hyperalgesia by Dripps, Isaac J., Bertels, Zachariah, Moye, Laura S., Tipton, Alycia F., Siegersma, Kendra, Baca, Serapio M., Kieffer, Brigitte L., Pradhan, Amynah A.

“…Delta opioid receptor (DOR) agonists have been identified as a promising novel therapy for headache disorders. DORs are broadly expressed in several peripheral…”
Get full text

Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition by Bertels, Zachariah, Singh, Harinder, Dripps, Isaac, Siegersma, Kendra, Tipton, Alycia F, Witkowski, Wiktor D, Sheets, Zoie, Shah, Pal, Conway, Catherine, Mangutov, Elizaveta, Ao, Mei, Petukhova, Valentina, Karumudi, Bhargava, Petukhov, Pavel A, Baca, Serapio M, Rasenick, Mark M, Pradhan, Amynah A

“…Migraine is the sixth most prevalent disease worldwide but the mechanisms that underlie migraine chronicity are poorly understood. Cytoskeletal flexibility is…”
Get full text

Effect of Histone Deacetylase Inhibitor on Ethanol Withdrawal-Induced Hyperalgesia in Rats by Pradhan, Amynah A, Tipton, Alycia F, Zhang, Huaibo, Akbari, Areeb, Pandey, Subhash C

“…Increased pain sensitivity is observed following alcohol withdrawal, and attempts to alleviate this hyperalgesia can contribute to the cycle of addiction. The…”
Get full text

PACAP-PAC1 receptor inhibition is effective in opioid induced hyperalgesia and medication overuse headache models by Bertels, Zachariah, Mangutov, Elizaveta, Siegersma, Kendra, Cropper, Haley C., Tipton, Alycia, Pradhan, Amynah A.

“…Opioids prescribed for pain and migraine can produce opioid-induced hyperalgesia (OIH) or medication overuse headache (MOH). We previously demonstrated that…”
Get full text

Delta opioid receptors in Nav1.8 expressing peripheral neurons partially regulate the effect of delta agonist in models of migraine and opioid-induced hyperalgesia by Bertels, Zachariah, Dripps, Isaac J., Shah, Pal, Moye, Laura S., Tipton, Alycia F., Siegersma, Kendra, Pradhan, Amynah A.

“…•DOR in Nav1.8 cells do not regulate anti-migraine effects of DOR agonist.•DOR in Nav1.8 cells is critical for effect of DOR agonist in peripheral OIH.•DOR in…”
Get full text

In vivo techniques to investigate the internalization profile of opioid receptors by Pradhan, Amynah A, Tawfik, Vivianne L, Tipton, Alycia F, Scherrer, Grégory

“…G-protein-coupled receptors (GPCRs) regulate a remarkable diversity of biological functions, and are thus often targeted for drug therapies. Receptor…”
Get more information

A PTEN-Regulated Checkpoint Controls Surface Delivery of δ Opioid Receptors by Shiwarski, Daniel J, Tipton, Alycia, Giraldo, Melissa D, Schmidt, Brigitte F, Gold, Michael S, Pradhan, Amynah A, Puthenveedu, Manojkumar A

“…The δ opioid receptor (δR) is a promising alternate target for pain management because δR agonists show decreased abuse potential compared with current opioid…”
Get full text

PACAP and Other Neuropeptide Targets Link Chronic Migraine and Opioid-induced Hyperalgesia in Mouse Models by Anapindi, Krishna D.B., Yang, Ning, Romanova, Elena V., Rubakhin, Stanislav S., Tipton, Alycia, Dripps, Isaac, Sheets, Zoie, Sweedler, Jonathan V., Pradhan, Amynah A.

“…The neuropeptides within seven nervous system regions involved in relaying pain signals have been identified and quantified in mouse models of chronic migraine…”
Get full text

A PTEN-Regulated Checkpoint Controls Surface Delivery of [delta] Opioid Receptors by Shiwarski, Daniel J, Tipton, Alycia, Giraldo, Melissa D, Schmidt, Brigitte F, Gold, Michael S, Pradhan, Amynah A, Puthenveedu, Manojkumar A

“…The [delta] opioid receptor ([delta]R) is a promising alternate target for pain management because [delta]R agonists show decreased abuse potential compared…”
Get full text

PACAP and Other Neuropeptide Targets Link Chronic Migraine and Opioid-induced Hyperalgesia in Mouse Models by Krishna, D B Anapindi, Yang, Ning, Romanova, Elena V, Rubakhin, Stanislav S, Tipton, Alycia, Dripps, Isaac, Sheets, Zoie, Sweedler, Jonathan V, Pradhan, Amynah A

“…Chronic use of opioids can produce opioid-induced hyperalgesia (OIH), and when used to treat migraine, these drugs can result in increased pain and headache…”
Get full text