Search Results - "Tio, Earvin S."

Evidence for the biopsychosocial model of suicide: a review of whole person modeling studies using machine learning by Tio, Earvin S, Misztal, Melissa C, Felsky, Daniel

“…Traditional approaches to modeling suicide-related thoughts and behaviors focus on few data types from often-siloed disciplines. While psychosocial aspects of…”
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Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression by Zhukovsky, Peter, Tio, Earvin S., Coughlan, Gillian, Bennett, David A., Wang, Yanling, Hohman, Timothy J., Pizzagalli, Diego A., Mulsant, Benoit H., Voineskos, Aristotle N., Felsky, Daniel

“…Approximately 40% of dementia cases could be prevented or delayed by modifiable risk factors related to lifestyle and environment. These risk factors, such as…”
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Unbiased classification of the elderly human brain proteome resolves distinct clinical and pathophysiological subtypes of cognitive impairment by Higginbotham, Lenora, Carter, E. Kathleen, Dammer, Eric B., Haque, Rafi U., Johnson, Erik C.B., Duong, Duc M., Yin, Luming, De Jager, Philip L., Bennett, David A., Felsky, Daniel, Tio, Earvin S., Lah, James J., Levey, Allan I., Seyfried, Nicholas T.

“…Cognitive impairment in the elderly features complex molecular pathophysiology extending beyond the hallmark pathologies of traditional disease classification…”
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CHRNA5 links chandelier cells to severity of amyloid pathology in aging and Alzheimer’s disease by Rybnicek, Jonas, Chen, Yuxiao, Milic, Milos, Tio, Earvin S., McLaurin, JoAnne, Hohman, Timothy J., De Jager, Philip L., Schneider, Julie A., Wang, Yanling, Bennett, David A., Tripathy, Shreejoy, Felsky, Daniel, Lambe, Evelyn K.

“…Changes in high-affinity nicotinic acetylcholine receptors are intricately connected to neuropathology in Alzheimer’s Disease (AD). Protective and…”
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Interactions between genetic risk for 21 neurodevelopmental and psychiatric disorders and sport activity on youth mental health by Misztal, Melissa C, Tio, Earvin S, Mohan, Akshay, Felsky, Daniel

“…Childhood is a sensitive period where behavioral disturbances, determined by genetics and environmental factors including sport activity, may emerge and impact…”
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Association of whole-person eigen-polygenic risk scores with Alzheimer's disease by Kharaghani, Amin, Tio, Earvin S, Milic, Milos, Bennett, David A, De Jager, Philip L, Schneider, Julie A, Sun, Lei, Felsky, Daniel

“…Late-Onset Alzheimer's Disease (LOAD) is a heterogeneous neurodegenerative disorder with complex etiology and high heritability. Its multifactorial risk…”
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Testing a Polygenic Risk Score for Morphological Microglial Activation in Alzheimer's Disease and Aging by Tio, Earvin S, Hohman, Timothy J, Milic, Milos, Bennett, David A, Felsky, Daniel

“…Neuroinflammation and the activation of microglial cells are among the earliest events in Alzheimer's disease (AD). However, direct observation of microglia in…”
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Diagnostic classification of childhood cancer using multiscale transcriptomics by Comitani, Federico, Nash, Joshua O., Cohen-Gogo, Sarah, Chang, Astra I., Wen, Timmy T., Maheshwari, Anant, Goyal, Bipasha, Tio, Earvin S., Tabatabaei, Kevin, Mayoh, Chelsea, Zhao, Regis, Ho, Ben, Brunga, Ledia, Lawrence, John E. G., Balogh, Petra, Flanagan, Adrienne M., Teichmann, Sarah, Huang, Annie, Ramaswamy, Vijay, Hitzler, Johann, Wasserman, Jonathan D., Gladdy, Rebecca A., Dickson, Brendan C., Tabori, Uri, Cowley, Mark J., Behjati, Sam, Malkin, David, Villani, Anita, Irwin, Meredith S., Shlien, Adam

“…The causes of pediatric cancers’ distinctiveness compared to adult-onset tumors of the same type are not completely clear and not fully explained by their…”
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Person‐specific differences in ubiquitin‐proteasome mediated proteostasis in human neurons by Hsieh, Yi‐Chen, Augur, Zachary M., Arbery, Mason, Ashour, Nancy, Barrett, Katharine, Pearse, Richard V., Tio, Earvin S., Duong, Duc M., Felsky, Daniel, De Jager, Philip L., Bennett, David A., Seyfried, Nicholas T., Young‐Pearse, Tracy L.

“…BACKGROUND Impairment of the ubiquitin‐proteasome system (UPS) has been implicated in abnormal protein accumulation in Alzheimer's disease. It remains unclear…”
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A Polygenic Risk Score for Hand Grip Strength is Associated with Cognitive Function in Mid‐to‐Late Life Adults by Bercovitch, Rachel, Tio, Earvin S., Felsky, Daniel

“…Background Lower muscular fitness is a risk factor for Alzheimer’s disease (AD). Hand grip strength (HGS) specifically ‐ a proxy for muscular fitness ‐ is a…”
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Relationship for co‐trajectories of cognitive decline and late‐life depression with postmortem neuropathology by Yang, Mu, Tio, Earvin S., Schneider, Julie A, Bennett, David A. A, Felsky, Daniel

“…Background The etiopathological relationship between late‐life cognitive decline and symptoms of depression remains unclear. Existing longitudinal studies have…”
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Genetic Architecture of Cortical Thickness and White Matter hyperintensities: Evidence of Gene‐Environment Interaction with Cardiovascular Health and Late‐Life Depression by Zhukovsky, Peter, Tio, Earvin S., Coughlan, Gillian T, Mulsant, Benoit H., Voineskos, Aristotle N., Felsky, Daniel

“…Background Modifiable risk factors account for over 40% of dementias, offering potential for intervention. However, the impact of these risk factors, including…”
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