Search Results - "Tintignac, Lionel A."

Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting by Tintignac, Lionel A, Brenner, Hans-Rudolf, Rüegg, Markus A

“…The neuromuscular junction is the chemical synapse between motor neurons and skeletal muscle fibers. It is designed to reliably convert the action potential…”
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Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy by Castets, Perrine, Lin, Shuo, Rion, Nathalie, Di Fulvio, Sabrina, Romanino, Klaas, Guridi, Maitea, Frank, Stephan, Tintignac, Lionel A., Sinnreich, Michael, Rüegg, Markus A.

“…Autophagy is a catabolic process that ensures homeostatic cell clearance and is deregulated in a growing number of myopathological conditions. Although FoxO3…”
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The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia by Ham, Daniel J., Börsch, Anastasiya, Lin, Shuo, Thürkauf, Marco, Weihrauch, Martin, Reinhard, Judith R., Delezie, Julien, Battilana, Fabienne, Wang, Xueyong, Kaiser, Marco S., Guridi, Maitea, Sinnreich, Michael, Rich, Mark M., Mittal, Nitish, Tintignac, Lionel A., Handschin, Christoph, Zavolan, Mihaela, Rüegg, Markus A.

“…With human median lifespan extending into the 80s in many developed countries, the societal burden of age-related muscle loss (sarcopenia) is increasing…”
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Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle by Ham, Daniel J., Börsch, Anastasiya, Chojnowska, Kathrin, Lin, Shuo, Leuchtmann, Aurel B., Ham, Alexander S., Thürkauf, Marco, Delezie, Julien, Furrer, Regula, Burri, Dominik, Sinnreich, Michael, Handschin, Christoph, Tintignac, Lionel A., Zavolan, Mihaela, Mittal, Nitish, Rüegg, Markus A.

“…Preserving skeletal muscle function is essential to maintain life quality at high age. Calorie restriction (CR) potently extends health and lifespan, but is…”
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Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21 by Guridi, Maitea, Tintignac, Lionel A, Lin, Shuo, Kupr, Barbara, Castets, Perrine, Rüegg, Markus A

“…Skeletal muscle is the largest organ, comprising 40% of the total body lean mass, and affects whole-body metabolism in multiple ways. We investigated the…”
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PKB and the mitochondria: AKTing on apoptosis by Parcellier, Arnaud, Tintignac, Lionel A., Zhuravleva, Elena, Hemmings, Brian A.

“…Cellular homeostasis depends upon the strict regulation of responses to external stimuli, such as signalling cascades triggered by nutrients and growth…”
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The initiation factor eIF3-f is a major target for Atrogin1/MAFbx function in skeletal muscle atrophy by Lagirand-Cantaloube, Julie, Offner, Nicolas, Csibi, Alfredo, Leibovitch, Marie P, Batonnet-Pichon, Sabrina, Tintignac, Lionel A, Segura, Carlos T, Leibovitch, Serge A

“…In response to cancer, AIDS, sepsis and other systemic diseases inducing muscle atrophy, the E3 ubiquitin ligase Atrogin1/MAFbx (MAFbx) is dramatically…”
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Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia by Börsch, Anastasiya, Ham, Daniel J., Mittal, Nitish, Tintignac, Lionel A., Migliavacca, Eugenia, Feige, Jérôme N., Rüegg, Markus A., Zavolan, Mihaela

“…Sarcopenia, the age-related loss of skeletal muscle mass and function, affects 5–13% of individuals aged over 60 years. While rodents are widely-used model…”
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Author Correction: Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle by Ham, Daniel J., Börsch, Anastasiya, Chojnowska, Kathrin, Lin, Shuo, Leuchtmann, Aurel B., Ham, Alexander S., Thürkauf, Marco, Delezie, Julien, Furrer, Regula, Burri, Dominik, Sinnreich, Michael, Handschin, Christoph, Tintignac, Lionel A., Zavolan, Mihaela, Mittal, Nitish, Rüegg, Markus A.

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The translation regulatory subunit eIF3f controls the kinase-dependent mTOR signaling required for muscle differentiation and hypertrophy in mouse by Csibi, Alfredo, Cornille, Karen, Leibovitch, Marie-Pierre, Poupon, Anne, Tintignac, Lionel A, Sanchez, Anthony M J, Leibovitch, Serge A

“…The mTORC1 pathway is required for both the terminal muscle differentiation and hypertrophy by controlling the mammalian translational machinery via…”
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Degradation of MyoD Mediated by the SCF (MAFbx) Ubiquitin Ligase by Tintignac, Lionel A., Lagirand, Julie, Batonnet, Sabrina, Sirri, Valentina, Leibovitch, Marie Pierre, Leibovitch, Serge A.

“…MyoD controls myoblast identity and differentiation and is required for myogenic stem cell function in adult skeletal muscle. MyoD is degraded by the…”
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AIMTOR, a BRET biosensor for live imaging, reveals subcellular mTOR signaling and dysfunctions by Bouquier, Nathalie, Moutin, Enora, Tintignac, Lionel A, Reverbel, Amandine, Jublanc, Elodie, Sinnreich, Michael, Chastagnier, Yan, Averous, Julien, Fafournoux, Pierre, Verpelli, Chiara, Boeckers, Tobias, Carnac, Gilles, Perroy, Julie, Ollendorff, Vincent

“…Abstract Background mTOR signaling is an essential nutrient and energetic sensing pathway. Here we describe AIMTOR, a sensitive genetically encoded BRET…”
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mTORC1 signalling is not essential for the maintenance of muscle mass and function in adult sedentary mice by Ham, Alexander S., Chojnowska, Kathrin, Tintignac, Lionel A., Lin, Shuo, Schmidt, Alexander, Ham, Daniel J., Sinnreich, Michael, Rüegg, Markus A.

“…Background The balance between protein synthesis and degradation (proteostasis) is a determining factor for muscle size and function. Signalling via the…”
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MAFbx/Atrogin-1 Controls the Activity of the Initiation Factor eIF3-f in Skeletal Muscle Atrophy by Targeting Multiple C-terminal Lysines by Csibi, Alfredo, Leibovitch, Marie Pierre, Cornille, Karen, Tintignac, Lionel A., Leibovitch, Serge A.

“…We recently presented evidence that the subunit eIF3-f of the eukaryotic initiation translation factor eIF3 that interacts with the E3-ligase Atrogin-1/muscle…”
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Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy by Bentzinger, C Florian, Lin, Shuo, Romanino, Klaas, Castets, Perrine, Guridi, Maitea, Summermatter, Serge, Handschin, Christoph, Tintignac, Lionel A, Hall, Michael N, Rüegg, Markus A

“…Skeletal muscle mass is determined by the balance between protein synthesis and degradation. Mammalian target of rapamycin complex 1 (mTORC1) is a master…”
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Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis by Kaiser, Marco S., Milan, Giulia, Ham, Daniel J., Lin, Shuo, Oliveri, Filippo, Chojnowska, Kathrin, Tintignac, Lionel A., Mittal, Nitish, Zimmerli, Christian E., Glass, David J., Zavolan, Mihaela, Rüegg, Markus A.

“…Muscle size is controlled by the PI3K-PKB/Akt-mTORC1-FoxO pathway, which integrates signals from growth factors, energy and amino acids to activate protein…”
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eIF3-f function in skeletal muscles: To stand at the crossroads of atrophy and hypertrophy by Csibi, Alfredo, Tintignac, Lionel A., Leibovitch, Marie Pierre, Leibovitch, Serge A.

“…The control of muscle cell size is a physiological process balanced by a fine tuning between protein synthesis and protein degradation. MAFbx/Atrogin-1 is a…”
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The Carboxy-Terminal Modulator Protein (CTMP) regulates mitochondrial dynamics by Parcellier, Arnaud, Tintignac, Lionel A, Zhuravleva, Elena, Dummler, Bettina, Brazil, Derek P, Hynx, Debby, Cron, Peter, Schenk, Susanne, Olivieri, Vesna, Hemmings, Brian A

“…Mitochondria are central to the metabolism of cells and participate in many regulatory and signaling events. They are looked upon as dynamic tubular networks…”
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Protein kinase B/Akt at a glance by Fayard, Elisabeth, Tintignac, Lionel A, Baudry, Anne, Hemmings, Brian A

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Dephosphorylation and Subcellular Compartment Change of the Mitotic Bloom's Syndrome DNA Helicase in Response to Ionizing Radiation by Dutertre, Stéphanie, Sekhri, Redha, Tintignac, Lionel A., Onclercq-Delic, Rosine, Chatton, Bruno, Jaulin, Christian, Amor-Guéret, Mounira

“…Bloom's syndrome is a rare human autosomal recessive disorder that combines a marked genetic instability and an increased risk of developing all types of…”
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