Search Results - "Tingle, M.D."

Pharmacokinetics of ‘party pill’ drug N-benzylpiperazine (BZP) in healthy human participants by Antia, U, Lee, H.S, Kydd, R.R, Tingle, M.D, Russell, B.R

“…Abstract There have been many reports of benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP) being used as recreational drugs which have been…”
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Effect of dose escalation on multiple dose pharmacokinetics of orally administered praziquantel in kingfish Seriola lalandi by Tubbs, L.A., Tingle, M.D.

“…Oral praziquantel (PZQ) preparations, administered using multiple dosing regimens, have recently been investigated for the treatment of monogenean parasites of…”
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The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: Chemical mechanisms and the effects of fluorine substitution by Tingle, M.D., Jewell, H., Maggs, J.L., O'Neill, P.M., Park, B.K.

“…Amodiaquine, a 4-aminoquinoline antimalarial, has been associated with hepatitis and agranulocytosis in humans. Drug hypersensitivity reactions, especially…”
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Cimetidine improves the therapeutic/toxic ratio of dapsone in patients on chronic dapsone therapy by Rhodes, L E, Tingle, M D, Park, B K, Chu, P, Verbov, J L, Friedmann, P S

“…We have previously shown that cimetidine, given concurrently for 2 weeks to patients on chronic dapsone therapy, reduced methaemoglobinaemia by inhibiting the…”
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Structural basis for the haemotoxicity of dapsone: the importance of the sulphonyl group by Mahmud, R., Tingle, M.D., Maggs, J.L., Cronin, M.T.D., Dearden, J.C., Park, B.K.

“…The structural basis of dapsone (4,4′-diaminodiphenyl sulphone) haemotoxicity has been determined by investigation of the in vitro bioactivation of a series of…”
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Can in vitro drug metabolism studies with human tissue replace in vivo animal studies? by Tingle, M.D., Helsby, N.A.

“…Animals provide a physiologically relevant system for evaluation of drug metabolism, but marked inter-species differences limit extrapolation to humans. Liver…”
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Drug-protein conjugates--XIV. Mechanisms of formation of protein-arylating intermediates from amodiaquine, a myelotoxin and hepatotoxin in man by Maggs, J L, Tingle, M D, Kitteringham, N R, Park, B K

“…The enzymic and non-enzymic formation of protein-arylating intermediates from amodiaquine (AQ,7-chloro-4-(3'-diethylamino-4'-hydroxyanilino) quinoline), an…”
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The effect of 2,2′-substitution on the metabolism and toxicity of dapsone in vitro and in vivo by Tingle, M.D, Mahmud, R, Maggs, J.L, Hawley, S, Coleman, M.D, Ward, S.A, Park, B.K

“…The effect of 2,2′-substitution with fluorine, methyl or trifluoromethyl groups on the toxicity, metabolism and pharmacological activity of dapsone has been…”
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Influence of glutathione conjugation on the immunogenicity of dinitrophenyl derivatives in the rat by Tingle, M D, Clarke, J B, Kitteringham, N R, Park, B K

“…The role of metabolic detoxication (glutathione conjugation) in the humoral response to three model haptens, dinitrofluorobenzene (DNFB), dinitrochlorobenzene…”
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Enzyme-linked immunosorbent assay (ELISA) for detection of antibodies to protein-reactive drugs and metabolites: criteria for identification of antibody activity. Detection and hapten specificity of anti-DNP, anti-captopril and anti-sulphanilamidobenzoic acid by Coleman, J W, Yeung, J H, Tingle, M D, Park, B K

“…Certain hypersensitivity reactions to drugs are thought to depend on coupling of reactive species (the drug itself or a metabolite) to macromolecules, leading…”
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