Search Results - "Ting, Harold"

Silibinin prevents prostate cancer cell-mediated differentiation of naïve fibroblasts into cancer-associated fibroblast phenotype by targeting TGF β2 by Ting, Harold J., Deep, Gagan, Jain, Anil K., Cimic, Adela, Sirintrapun, Joseph, Romero, Lina M., Cramer, Scott D., Agarwal, Chapla, Agarwal, Rajesh

“…Tumor microenvironment (TM) is an essential element in prostate cancer (PCA), offering unique opportunities for its prevention. TM includes naïve fibroblasts…”
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Platelet function and Isoprostane biology. Should isoprostanes be the newest member of the orphan-ligand family? by Ting, Harold J, Khasawneh, Fadi T

“…While there have been many reports investigating the biological activity and signaling mechanisms of isoprostanes, their role in biology, particularly in…”
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Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules by Ramteke, Anand, Ting, Harold, Agarwal, Chapla, Mateen, Samiha, Somasagara, Ranganathan, Hussain, Anowar, Graner, Michael, Frederick, Barbara, Agarwal, Rajesh, Deep, Gagan

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CD11c/CD18: novel ligands and a role in delayed-type hypersensitivity by Sadhu, Chanchal, Ting, Harold J., Lipsky, Brian, Hensley, Kelly, Garcia‐Martinez, Leon F., Simon, Scott I., Staunton, Donald E.

“…CD11c, a member of the leukointegrin family, is expressed prominently on tissue macrophages and dendritic cells and binds to complement fragment (iC3b),…”
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Triglyceride-Rich Lipoproteins Prime Aortic Endothelium for an Enhanced Inflammatory Response to Tumor Necrosis Factor-α by Ting, Harold J, Stice, James P, Schaff, Ulrich Y, Hui, David Y, Rutledge, John C, Knowlton, Anne A, Passerini, Anthony G, Simon, Scott I

“…High levels of triglyceride-rich lipoproteins (TGRLs) in blood are linked to development of atherosclerosis, yet the mechanisms by which these particles…”
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Mouse transient receptor potential channel 6: Role in hemostasis and thrombogenesis by Paez Espinosa, Enma V., Murad, John P., Ting, Harold J., Khasawneh, Fadi T.

“…► The transient receptor potential channel 6 (TRPC6) plays a key role in hemostasis. ► TRPC6 plays a key role in the pathogenesis of occlusive thrombotic…”
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Glybenclamide: An antidiabetic with in vivo antithrombotic activity by Ting, Harold J., Khasawneh, Fadi T.

“…While proper platelet function is a vital component of hemostasis, their inappropriate activation contributes to thrombotic disorders. One pathway for platelet…”
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Spatial Regulation of Inflammation by Human Aortic Endothelial Cells in a Linear Gradient of Shear Stress by Tsou, Jean K., Gower, R. Michael, Ting, Harold J., Schaff, Ulrich Y., Insana, Michael F., Passerini, Anthony G., Simon, Scott I.

“…Objective: Atherosclerosis is a focal disease that develops at sites of low and oscillatory shear stress in arteries. This study aimed to understand how…”
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A novel antibody targeting the ligand binding domain of the thromboxane A2 receptor exhibits antithrombotic properties in vivo by Murad, John P., Espinosa, Enma Veronica Paez, Ting, Harold J., McClure, Diane, Khasawneh, Fadi T.

“…► C-EL2Ab exhibits thromboxane A2 receptor-specific antiplatelet activity, ex vivo. ► C-EL2Ab protects against the development of occlusive thrombotic…”
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The C-terminal segment of the second extracellular loop of the thromboxane A2 receptor plays an important role in platelet aggregation by MURAD, John P, ESPINOSA, Enma Veronica Paez, TING, Harold J, KHASAWNEH, Fadi T

“…There is considerable interest in discovering novel antiplatelet approaches with an enhanced safety profile. To this end, in our efforts to define new targets…”
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Repurposing an old drug for a new use： glybenclamide exerts antiplatelet activity by interacting with the thromboxane A2 receptor by Ting, Harold J, Murray, Wallace J, Khasawneh, Fadi T

“…Aim： To investigate the potential antagonistic activity of the antidiabetic agent glybenclamide for the human platelet thromboxane A2 receptor （abbreviated as…”
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Thromboxane A2 receptor: biology and function of a peculiar receptor that remains resistant for therapeutic targeting by Ting, Harold J, Murad, John P, Espinosa, Enma V P, Khasawneh, Fadi T

“…While blood platelets express several G-protein-coupled receptors (GPCRs) that play pivotal roles in their activation, several diseases, for example thrombotic…”
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Repurposing an old drug for a new use: glybenclamide exerts antiplatelet activity by interacting with the thromboxane A receptor by Ting, Harold J, Murray, Wallace J, Khasawneh, Fadi T

“…To investigate the potential antagonistic activity of the antidiabetic agent glybenclamide for the human platelet thromboxane A(2) receptor (abbreviated as…”
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Characterization of the in vivo antiplatelet activity of the antihypertensive agent losartan by Murad, John P, Espinosa, Enma V P, Ting, Harold J, Khasawneh, Fadi T

“…The purpose of this study is to investigate the potential in vivo antiplatelet and thromboprotective properties of the antihypertensive drug losartan in mice…”
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Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules by Ramteke, Anand, Ting, Harold, Agarwal, Chapla, Mateen, Samiha, Somasagara, Ranganathan, Hussain, Anowar, Graner, Michael, Frederick, Barbara, Agarwal, Rajesh, Deep, Gagan

“…Hypoxic conditions in prostate cancer (PCA) are associated with poor prognosis; however, precise mechanism/s through which hypoxia promotes malignant phenotype…”
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Molecular Mechanisms of Silibinin-Mediated Cancer Chemoprevention with Major Emphasis on Prostate Cancer by Ting, Harold, Deep, Gagan, Agarwal, Rajesh

“…Despite advances in early detection, prostate cancer remains the second highest cancer mortality in American men, and even successful interventions are…”
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Beneficial effects of the naturally occurring flavonoid silibinin on the prostate cancer microenvironment: role of monocyte chemotactic protein-1 and immune cell recruitment by Ting, Harold, Deep, Gagan, Kumar, Sushil, Jain, Anil K, Agarwal, Chapla, Agarwal, Rajesh

“…Tumor microenvironment plays an essential role in prostate carcinogenesis and offers novel opportunities to prevent and treat prostate cancer (PCA). Here, we…”
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Silibinin enhances the repair of ultraviolet B-induced DNA damage by activating p53-dependent nucleotide excision repair mechanism in human dermal fibroblasts by Guillermo-Lagae, Ruth, Deep, Gagan, Ting, Harold, Agarwal, Chapla, Agarwal, Rajesh

“…Ultraviolet radiation B (UVB) is the main cause of DNA damage in epidermal cells; and if not repaired, this DNA damage leads to skin cancer. In earlier…”
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SNAI1 is critical for the aggressiveness of prostate cancer cells with low E-cadherin by Deep, Gagan, Jain, Anil K, Ramteke, Anand, Ting, Harold, Vijendra, Kavitha C, Gangar, Subhash C, Agarwal, Chapla, Agarwal, Rajesh

“…A better molecular understanding of prostate carcinogenesis is warranted to devise novel targeted preventive and therapeutic strategies against prostate cancer…”
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A Novel Parenteral Formulation For the Antiplatelet Agent Clopidogrel by Karim, Zubair A, Venkatesan, Natarajan, Ting, Harold J, Betageri, Guru, Khasawneh, Fadi T

“…Abstract only While platelets play a vital role in preventing excessive bleeding after injury (hemostasis), they also contribute to the genesis of thrombotic…”
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