Search Results - "Tinelli, S."

Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment by Gatti, L, Cossa, G, Tinelli, S, Carenini, N, Arrighetti, N, Pennati, M, Cominetti, D, De Cesare, M, Zunino, F, Zaffaroni, N, Perego, P

“…Since response to platinum-based therapy in non-small-cell lung cancer (NSCLC) is poor, the present study was designed to rationally identify novel drug…”
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Bullying behaviours among students in Pavia, Italy: prevalence and association with stress and cannabis use by Martinelli, V, Brondino, N, Rossi, S, Panigati, R, Magnani, R, Cappucciati, M, Vecchia, L, Tinelli, S, Emanuele, E, Politi, P

“…This study examined the prevalence of students' reported experiences of bullying and victimization in primary and secondary schools and their association with…”
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Unique sequence specificity of topoisomerase II DNA cleavage stimulation and DNA binding mode of streptonigrin by Capranico, G, Palumbo, M, Tinelli, S, Zunino, F

“…Streptonigrin stimulated unique intensity patterns of topoisomerase II-mediated DNA cleavage in agarose and sequencing gels with no similarity to those of…”
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OC-0265 MiR-205 enhances radiation sensitivity of prostate cancer cells through PKCε and ZEB1 inhibition by El Bezawy, R., Tinelli, S., Cicchetti, A., Valdagni, R., Gandellini, P., Zaffaroni, N.

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Evidence of DNA topoisomerase II-dependent mechanisms of multidrug resistance in P388 leukemia cells by De Isabella, P, Capranico, G, Binaschi, M, Tinelli, S, Zunino, F

“…A multidrug-resistant variant of the P388 leukemia cell line exhibits multiple biochemical changes, including reduced drug accumulation and markedly reduced…”
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Conformational properties of topoisomerase II inhibitors and sequence specificity of DNA cleavage by Palumbo, M, Mabilia, M, Pozzan, A, Capranico, G, Tinelli, S, Zunino, F

“…The sequence specificity of topoisomerase-II-mediated DNA cleavage, stimulated by 2-methyl-9-hydroxy ellipticinium and 4',5,7-trihydroxyflavone (genistein) was…”
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Drug sensitivity and sequence specificity of human recombinant DNA topoisomerases IIalpha (p170) and IIbeta (p180) by Cornarotti, M, Tinelli, S, Willmore, E, Zunino, F, Fisher, L M, Austin, C A, Capranico, G

“…Effective anticancer agents, such as epipodophyllotoxins and anthracyclines, exert their antitumor activity through stabilization of cleavable topoisomerase…”
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Poly-L-aspartic acid as a carrier for doxorubicin: a comparative in vivo study of free and polymer-bound drug by PRATESI, G, SAVI, G, PEZZONI, G, BELLINI, O, PENCO, S, TINELLI, S, ZUNINO, F

“…The synthetic polypeptide, poly-L-aspartic acid (PAA, mol. wt = 20,000) has been used as a macromolecular carrier for doxorubicin. The drug may be released in…”
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Cellular pharmacology of cisplatin in relation to the expression of human copper transporter CTR1 in different pairs of cisplatin-sensitive and -resistant cells by Beretta, Giovanni Luca, Gatti, Laura, Tinelli, Stella, Corna, Elisabetta, Colangelo, Donato, Zunino, Franco, Perego, Paola

“…The molecular mechanism of cisplatin uptake remains poorly defined and impaired drug accumulation may be implicated in the acquisition of resistance to…”
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Potent antitumor activity and improved pharmacological profile of ST1481, a novel 7-substituted camptothecin by DE CESARE, Michelandrea, PRATESI, Graziella, PACE, Silvia, CAPOCASA, Francesca, CARMINATI, Paolo, ZUNINO, Franco, PEREGO, Paola, CARENINI, Nives, TINELLI, Stella, MERLINI, Lucio, PENCO, Sergio, PISANO, Claudio, BUCCI, Federica, VESCI, Loredana

“…Relevant drawbacks of the molecular structure and mechanism of the action of camptothecins are the instability of the E ring lactone and the reversibility of…”
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Cucurbitane Triterpenes from the Fruiting Bodies and Cultivated Mycelia of Leucopaxillus gentianeus by Clericuzio, Marco, Tabasso, Silvia, Bianco, Maria Ausilia, Pratesi, Graziella, Beretta, Giovanni, Tinelli, Stella, Zunino, Franco, Vidari, Giovanni

“…A reinvestigation of the fruiting bodies of the mushroom Leucopaxillus gentianeus, allowed the isolation of two minor cucurbitane triterpenes, namely,…”
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Simultaneous confidence intervals to compare gene expression profiles using ABC transporter TaqMan microfluidic cards by SARA PIZZAMIGLIO, COSSA, Giacomo, GATTI, Laura, BERETTA, Giovanni L, CORNA, Elisabetta, TINELLI, Stella, VERDERIO, Paolo, PEREGO, Paola

“…The rapid evolution of techniques for measuring gene expression makes available substantial data which require careful analysis. In particular, relative…”
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Development of resistance to a trinuclear platinum complex in ovarian carcinoma cells by Perego, Paola, Gatti, Laura, Righetti, Sabina C., Beretta, Giovanni L., Carenini, Nives, Corna, Elisabetta, Bo, Laura Dal, Tinelli, Stella, Colangelo, Donato, Leone, Roberto, Apostoli, Piero, Lombardi, Luciano, Beggiolin, Gino, Piazzoni, Laura, Zunino, Franco

“…BBR3464 is a trinuclear platinum complex that exhibits a potent cytotoxicity and efficacy against cisplatin‐resistant tumors. To better understand the…”
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Synthesis and cytotoxic activity of substituted 7-aryliminomethyl derivatives of camptothecin by Dallavalle, Sabrina, Merlini, Lucio, Morini, Gabriella, Musso, Loana, Penco, Sergio, Beretta, Giovanni Luca, Tinelli, Stella, Zunino, Franco

“…A series of imines derived from camptothecin-7-aldehyde (CPT-CHO) and aromatic amines were synthesised and tested for their cytotoxicity against tumour cell…”
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Topoisomerase poisoning activity of novel disaccharide anthracyclines by Guano, F, Pourquier, P, Tinelli, S, Binaschi, M, Bigioni, M, Animati, F, Manzini, S, Zunino, F, Kohlhagen, G, Pommier, Y, Capranico, G

“…Doxorubicin and idarubicin are very effective anticancer drugs in the treatment of human hematological malignancies and solid tumors. These agents are well…”
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Observations on the life cycle and ecology of two syntopic populations of Cicindela hybrida and C. majalis in northern Italy (Coleoptera, Cicindelidae) by Cassola, F, Pattarini, A, Tinelli, S

“…The results are reported of a field study carried out in 2003 and 2004 on two syntopic populations of Cicindela hybrida ssp. transversalis and C. majalis in…”
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Conformational drug determinants of the sequence specificity of drug-stimulated topoisomerase II DNA cleavage by Capranico, G, Palumbo, M, Tinelli, S, Mabilia, M, Pozzan, A, Zunino, F

“…To gain further knowledge of the molecular features of topoisomerase II inhibitors required for drug-receptor complex formation, we investigated the…”
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Genomic sites of topoisomerase II activity determined by comparing DNA breakage enhanced by three distinct poisons by Borgnetto, M.E, Tinelli, S, Carminati, L, Capranico, G

“…To define the sites of topoisomerase II activity in two genomic regions of Drosophila melanogaster Kc cells, we have investigated in vivo DNA cleavage sites…”
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Similar sequence specificity of mitoxantrone and VM-26 stimulation of in vitro DNA cleavage by mammalian DNA topoisomerase II by Capranico, Giovanni, De Isabella, Paola, Tinelli, Stella, Bigioni, Mario, Zunino, Franco

“…The molecular mechanism of topoisomerase II trapping by antitumor drugs probably involves the formation of a ternary complex DNA-drug-topoisomerase II. Recent…”
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Drug-specific sites of topoisomerase II DNA cleavage in Drosophila chromatin : Heterogeneous localization and reversibility by BORGNETTO, M. E, ZUNINO, F, TINELLI, S, KÄS, E, CAPRANICO, G

“…DNA cleavage stimulated by different topoisomerase II inhibitors shows in vitro a characteristic sequence specificity. Since chromatin structure and genome…”
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