Search Results - "Tinel, M"

Extreme precipitation time trends in Ontario, 1960-2010 by Soulis, E. D., Sarhadi, A., Tinel, M., Suthar, M.

“…The impact of climate change on the behaviour of intensity–duration–frequency curves is critical to the estimation of design storms, and thus to the safe…”
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Interactions of dihydralazine with cytochromes P4501A: a possible explanation for the appearance of anti-cytochrome P4501A2 autoantibodies by Bourdi, M, Tinel, M, Beaune, P H, Pessayre, D

“…The antihypertensive drug dihydralazine may, on rare occasions, cause immunoallergic hepatitis characterized by anti-cytochrome P450 (P450)1A2 autoantibodies…”
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Press imprint smear: a rapid, simple, and cheap method for the diagnosis of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis by Sousa, Anastácio Q, Pompeu, Margarida M L, Frutuoso, Mércia S, Lima, José W O, Tinel, Juliana M B M, Pearson, Richard D

“…A modified imprint method, Press-Imprint-Smear, was compared with histopathology for the diagnosis of cutaneous leishmaniasis. Amastigotes were seen in 69…”
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Effects of clarithromycin on cytochrome P-450. Comparison with other macrolides by Tinel, M, Descatoire, V, Larrey, D, Loeper, J, Labbe, G, Letteron, P, Pessayre, D

“…Repeated administration of clarithromycin (0.5 mmol.kg-1 p.o. daily for 5 days) to rats increased markedly the same cytochrome P-450 isoenzyme (P-450p) as that…”
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Administration of high doses of human recombinant interleukin-2 decreases the expression of several cytochromes P-450 in the rat by Thal, C, el Kahwaji, J, Loeper, J, Tinel, M, Doostzadeh, J, Labbe, G, Leclaire, J, Beaune, P, Pessayre, D

“…Human recombinant interleukin-2 (IL-2) administration is being tested in patients with advanced cancer. Its effects on the expression of cytochromes P-450 were…”
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Inactivation of cytochrome P-450 by the drug methoxsalen by Fouin-Fortunet, H, Tinel, M, Descatoire, V, Letteron, P, Larrey, D, Geneve, J, Pessayre, D

“…Administration of methoxsalen (50 mumol X kg-1 i.p.) increased 4-fold the hexobarbital sleeping time in rats; at this low dose, SKF 525-A, piperonyl butoxide…”
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Pharmacogenetics of human erythrocyte thiopurine methyltransferase activity in a French population by Tinel, M, Berson, A, Pessayre, D, Letteron, P, Cattoni, MP, Horsmans, Y, Larrey, D

“…1. A genetic polymorphism in human erythrocyte thiopurine methyltransferase activity (RBC TPMT) resulting in a trimodal phenotypic distribution has been…”
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Inactivation and induction of cytochrome P-450 by various psoralen derivatives in rats by Letteron, P, Descatoire, V, Larrey, D, Tinel, M, Geneve, J, Pessayre, D

“…8-Methoxypsoralen has been shown to both inactivate and induce microsomal enzymes. We report here the effects of other psoralen derivatives in rats. CO-binding…”
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What changes drug metabolism in critically ill patients? Two preliminary studies in isolated human hepatocytes by Park, G R, Pichard, L, Tinel, M, Larroque, C, Elston, A, Domerque, J, Dexionne, B, Maurel, P

“…The metabolism of many drugs is abnormal in the critically ill patient. The causes of this are unknown, and investigation in patients is difficult. We…”
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Polymorphism of dextromethorphan oxidation in a French population by Larrey, D, Amouyal, G, Tinel, M, Letteron, P, Berson, A, Labbe, G, Pessayre, D

“…Genetically‐controlled drug oxidation capacity was studied using dextromethorphan, an anti‐tussive drug, as the test compound in 103 healthy white French…”
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Effects of pregnancy on the toxicity and metabolism of acetaminophen in mice by Larrey, D, Letteron, P, Foliot, A, Descatoire, V, Degott, C, Geneve, J, Tinel, M, Pessayre, D

“…Although acetaminophen is widely used in pregnant women, the effects of pregnancy on its hepatotoxicity remain unknown. We assessed these effects in pregnant…”
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Inactivation of cytochrome P-450 by a troleandomycin metabolite. Protective role of glutathione by Pessayre, D, Tinel, M, Larrey, D, Cobert, B, Funck-Brentano, C, Babany, G

“…Troleandomycin, a macrolide antibiotic, has been shown to be demethylated and oxidized into a metabolite which forms an inactive complex with the iron(II) of…”
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Soins infirmiers en réanimation lors de l’oxygénothérapie humidifiée à haut débit by Tigreat, J., Kolakowski, A., Tinel, M. -E.

“…Résumé L’oxygénothérapie fait partie des soins banalisés dans les services d’urgence et de réanimation. Une nouvelle technique est maintenant disponible en…”
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Inhibition of rat liver estrogen 2/4-hydroxylase activity by troleandomycin: comparison with erythromycin and roxithromycin by Fisher, D, Labbe, G, Berson, A, Tinel, M, Loeper, J, Larrey, D, Pessayre, D

“…Administration of troleandomycin (0.5 mmol.kg-1 p.o. daily for 5 days) decreased by 61% and 36%, respectively, the estradiol and ethinylestradiol…”
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Impaired adaptive resynthesis and prolonged depletion of hepatic mitochondrial DNA after repeated alcohol binges in mice by Demeilliers, Christine, Maisonneuve, Caroline, Grodet, Alain, Mansouri, Abdellah, Nguyen, Richard, Tinel, Marina, Lettéron, Philippe, Degott, Claude, Feldmann, GéRard, Pessayre, Dominique, Fromenty, Bernard

“…Background & Aims: A single dose of alcohol causes transient hepatic mitochondrial DNA (mtDNA) depletion in mice followed by increased mtDNA synthesis and an…”
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Effect of liver disease on dextromethorphan oxidation capacity and phenotype: a study in 107 patients by Larrey, D., Babany, G., Tinel, M., Freneaux, E., Amouyal, G., Habersetzer, F., Letteron, P., Pessayre, D.

“…1. The O‐demethylation of dextromethorphan to dextrorphan exhibits a genetically‐controlled polymorphism, co‐segregating with that of debrisoquine…”
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Nilutamide inhibits mephenytoin 4-hydroxylation in untreated male rats and in human liver microsomes by Horsmans, Y, Lannes, D, Larrey, D, Tinel, M, Letteron, P, Loeper, J, Pessayre, D

“…1. The effects of nilutamide (an anti-androgen with a hydantoin moiety) on the 4-hydroxylation of mephenytoin were studied in rat liver microsomes. Nilutamide,…”
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Differences in hepatic drug accumulation and enzyme induction after chronic amiodarone feeding of two rat strains: role of the hydroxylator phenotype? by Pirovino, M., Honegger, U., Müller, O., Zysset, Th, Küpfer, A., Tinel, M., Pessayre, D.

“…1 It has previously been shown that the extent of hepatic phospholipidosis induced by chronic amiodarone treatment correlates with the degree of drug…”
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The anti-inflammatory drug, nimesulide (4-nitro-2-phenoxymethane-sulfoanilide), uncouples mitochondria and induces mitochondrial permeability transition in human hepatoma cells: protection by albumin by Berson, Alain, Cazanave, Sophie, Descatoire, Véronique, Tinel, Marina, Grodet, Alain, Wolf, Claude, Feldmann, Gérard, Pessayre, Dominique

“…Like other nonsteroidal anti-inflammatory drugs, nimesulide (4-nitro-2-phenoxymethane-sulfoanilide) triggers hepatitis in a few recipients. Although nimesulide…”
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Self-induction by oleandomycin of its own transformation into a metabolite forming an inactive complex with reduced cytochrome P-450. Comparison with troleandomycin by Pessayre, D, Descatoire, V, Tinel, M, Larrey, D

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