Search Results - "Timur Naim"

Defective fasting-induced PKA activation impairs adipose tissue glycogen degradation in obese Zucker rats by Flores-Opazo, Marcelo, Trieu, Jennifer, Naim, Timur, Valladares-Ide, Denisse, Zbinden-Foncea, Hermann, Stapleton, David

“…Background Obesity is associated with development of insulin resistance in adipose tissue (AT). Human obesity has been associated with increased glycogen…”
Get full text

Mas Receptor Activation Slows Tumor Growth and Attenuates Muscle Wasting in Cancer by Murphy, Kate T, Hossain, Mohammed I, Swiderski, Kristy, Chee, Annabel, Naim, Timur, Trieu, Jennifer, Haynes, Vanessa, Read, Suzannah J, Stapleton, David I, Judge, Sarah M, Trevino, Jose G, Judge, Andrew R, Lynch, Gordon S

“…Cancer cachexia is a multifactorial syndrome characterized by a progressive loss of skeletal muscle mass associated with significant functional impairment…”
Get full text

Glycine administration attenuates progression of dystrophic pathology in prednisolone-treated dystrophin/utrophin null mice by Ham, Daniel J., Gardner, Anastasia, Kennedy, Tahnee L., Trieu, Jennifer, Naim, Timur, Chee, Annabel, Alves, Francesca M., Caldow, Marissa K., Lynch, Gordon S., Koopman, René

“…Duchenne muscular dystrophy (DMD) is an X-linked genetic disease characterized by progressive muscle wasting and weakness and premature death. Glucocorticoids…”
Get full text

Deletion of suppressor of cytokine signaling 3 (SOCS3) in muscle stem cells does not alter muscle regeneration in mice after injury by Swiderski, Kristy, Caldow, Marissa K, Naim, Timur, Trieu, Jennifer, Chee, Annabel, Koopman, René, Lynch, Gordon S

“…Muscles of older animals are more susceptible to injury and regenerate poorly, in part due to a persistent inflammatory response. The janus kinase (Jak)/signal…”
Get full text

Antibody-directed myostatin inhibition enhances muscle mass and function in tumor-bearing mice by Murphy, Kate T, Chee, Annabel, Gleeson, Ben G, Naim, Timur, Swiderski, Kristy, Koopman, René, Lynch, Gordon S

“…Cancer cachexia describes the progressive skeletal muscle wasting and weakness in many cancer patients and accounts for >20% of cancer-related deaths. We…”
Get more information

The BALB/c.mdx62 mouse exhibits a dystrophic muscle pathology and is a model of Duchenne muscular dystrophy by Swiderski, Kristy, Chan, Audrey S, Herold, Marco J, Kueh, Andrew J, Chung, Jin D, Hardee, Justin P, Trieu, Jennifer, Chee, Annabel, Naim, Timur, Gregorevic, Paul, Lynch, Gordon S

“…Duchenne muscular dystrophy (DMD) is a devastating monogenic skeletal muscle-wasting disorder. Although many pharmacological and genetic interventions have…”
Get full text

Antibody‐directed myostatin inhibition in 21‐mo‐old mice reveals novel roles for myostatin signaling in skeletal muscle structure and function by Murphy, Kate T., Koopman, René, Naim, Timur, Léger, Bertrand, Trieu, Jennifer, Ibebunjo, Chikwendu, Lynch, Gordon S.

“…ABSTRACTSarcopenia is the progressive loss of skeletal muscle mass and function with advancing age, leading to reduced mobility and quality of life. We tested…”
Get full text

Importance of functional and metabolic impairments in the characterization of the C-26 murine model of cancer cachexia by Murphy, Kate T, Chee, Annabel, Trieu, Jennifer, Naim, Timur, Lynch, Gordon S

“…Cancer cachexia describes the progressive skeletal muscle wasting and weakness that is associated with many cancers. It impairs quality of life and accounts…”
Get full text

Investigating the Potential for Sulforaphane to Attenuate Gastrointestinal Dysfunction in mdx Dystrophic Mice by Swiderski, Kristy, Read, Suzannah J, Chan, Audrey S, Chung, Jin D, Trieu, Jennifer, Naim, Timur, Koopman, René, Lynch, Gordon S

“…Gastrointestinal (GI) dysfunction is an important, yet understudied condition associated with Duchenne muscular dystrophy (DMD), with patients reporting…”
Get full text

Dystrophin S3059 phosphorylation partially attenuates denervation atrophy in mouse tibialis anterior muscles by Swiderski, Kristy, Naim, Timur, Trieu, Jennifer, Chee, Annabel, Herold, Marco J., Kueh, Andrew J., Goodman, Craig A., Gregorevic, Paul, Lynch, Gordon S.

“…The dystrophin protein has well‐characterized roles in force transmission and maintaining membrane integrity during muscle contraction. Studies have reported…”
Get full text

Dysfunctional muscle and liver glycogen metabolism in mdx dystrophic mice by Stapleton, David I, Lau, Xianzhong, Flores, Marcelo, Trieu, Jennifer, Gehrig, Stefan M, Chee, Annabel, Naim, Timur, Lynch, Gordon S, Koopman, René

“…Duchenne muscular dystrophy (DMD) is a severe, genetic muscle wasting disorder characterised by progressive muscle weakness. DMD is caused by mutations in the…”
Get full text

Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity by Hardee, Justin P., Martins, Karen J.B., Miotto, Paula M., Ryall, James G., Gehrig, Stefan M., Reljic, Boris, Naim, Timur, Chung, Jin D., Trieu, Jen, Swiderski, Kristy, Philp, Ashleigh M., Philp, Andrew, Watt, Matthew J., Stroud, David A., Koopman, Rene, Steinberg, Gregory R., Lynch, Gordon S.

“…Preferential damage to fast, glycolytic myofibers is common in many muscle-wasting diseases, including Duchenne muscular dystrophy (DMD). Promoting an…”
Get full text

Spatiotemporal Mapping Reveals Regional Gastrointestinal Dysfunction in mdx Dystrophic Mice Ameliorated by Oral L-arginine Supplementation by Swiderski, Kristy, Bindon, Rebecka, Trieu, Jennifer, Naim, Timur, Schokman, Shana, Swaminathan, Mathusi, Leembruggen, Anita J L, Hill-Yardin, Elisa L, Koopman, René, Bornstein, Joel C, Lynch, Gordon S

“…Patients with Duchenne muscular dystrophy exhibit significant, ongoing impairments in gastrointestinal (GI) function likely resulting from dysregulated nitric…”
Get full text

Functional β-adrenoceptors are important for early muscle regeneration in mice through effects on myoblast proliferation and differentiation by Church, Jarrod E, Trieu, Jennifer, Sheorey, Radhika, Chee, Annabel Y-M, Naim, Timur, Baum, Dale M, Ryall, James G, Gregorevic, Paul, Lynch, Gordon S

“…Muscles can be injured in different ways and the trauma and subsequent loss of function and physical capacity can impact significantly on the lives of patients…”
Get full text

Disruption of muscle renin-angiotensin system in AT1a-/- mice enhances muscle function despite reducing muscle mass but compromises repair after injury by Murphy, Kate T, Allen, Andrew M, Chee, Annabel, Naim, Timur, Lynch, Gordon S

“…The role of the renin-angiotensin system (RAS) in vasoregulation is well established, but a localized RAS exists in multiple tissues and exerts diverse…”
Get more information

Mechanisms of chemotherapy‐induced muscle wasting in mice with cancer cachexia by Murphy, Kate T., Swiderski, Kristy, Ryall, James G., Davey, Jonathan R., Qian, Hongwei, Lamon, Séverine, Foletta, Victoria C., Trieu, Jennifer, Chee, Annabel, Read, Suzannah J., Naim, Timur, Gregorevic, Paul, Lynch, Gordon S.

“…Background Cachexia is a debilitating complication of cancer characterized by progressive wasting and weakness of skeletal muscles that reduces quality of life…”
Get full text

Spatiotemporal Mapping Reveals Regional Gastrointestinal Dysfunction in mdx Dystrophic Mice Ameliorated by Oral L-arginine Supplementation by Kristy Swiderski, Rebecka Bindon, Jennifer Trieu, Timur Naim, Shana Schokman, Mathusi Swaminathan, Anita J L Leembruggen, Elisa L Hill-yardin, Rene Koopman, Joel C Bornstein, Gordon S Lynch

“…Background/Aims Patients with Duchenne muscular dystrophy exhibit significant, ongoing impairments in gastrointestinal (GI) function likely resulting from…”
Get full text

Comprehensive characterization of single-cell full-length isoforms in human and mouse with long-read sequencing by Tian, Luyi, Jabbari, Jafar S, Thijssen, Rachel, Gouil, Quentin, Amarasinghe, Shanika L, Voogd, Oliver, Kariyawasam, Hasaru, Du, Mei R M, Schuster, Jakob, Wang, Changqing, Su, Shian, Dong, Xueyi, Law, Charity W, Lucattini, Alexis, Prawer, Yair David Joseph, Collar-Fernández, Coralina, Chung, Jin D, Naim, Timur, Chan, Audrey, Ly, Chi Hai, Lynch, Gordon S, Ryall, James G, Anttila, Casey J A, Peng, Hongke, Anderson, Mary Ann, Flensburg, Christoffer, Majewski, Ian, Roberts, Andrew W, Huang, David C S, Clark, Michael B, Ritchie, Matthew E

“…A modified Chromium 10x droplet-based protocol that subsamples cells for both short-read and long-read (nanopore) sequencing together with a new computational…”
Get full text

Deletion of suppressor of cytokine signaling 3 by Swiderski, Kristy, Caldow, Marissa K, Naim, Timur, Trieu, Jennifer, Chee, Annabel, Koopman, René, Lynch, Gordon S

“…Muscles of older animals are more susceptible to injury and regenerate poorly, in part due to a persistent inflammatory response. The janus kinase (Jak)/signal…”
Get full text

The BALB/c. mdx 62 mouse exhibits a dystrophic muscle pathology and is a model of Duchenne muscular dystrophy by Swiderski, Kristy, Chan, Audrey S., Herold, Marco J., Kueh, Andrew J., Chung, Jin D., Hardee, Justin P., Trieu, Jennifer, Chee, Annabel, Naim, Timur, Gregorevic, Paul, Lynch, Gordon S.

“…ABSTRACT Duchenne muscular dystrophy (DMD) is a devastating monogenic skeletal muscle-wasting disorder. Although many pharmacological and genetic interventions…”
Get full text