Search Results - "Timsit, Yoav E."

CAR and PXR: The xenobiotic-sensing receptors by Timsit, Yoav E., Negishi, Masahiko

“…The xenobiotic receptors CAR and PXR constitute two important members of the NR1I nuclear receptor family. They function as sensors of toxic byproducts derived…”
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Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system by Timsit, Yoav E, Negishi, Masahiko

“…The constitutive active/androstane receptor (CAR) plays an important role as a coordinate transcription factor in the regulation of various hepatic metabolic…”
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TRANSCRIPTIONAL SUPPRESSION OF CYTOCHROME P450 GENES BY ENDOGENOUS AND EXOGENOUS CHEMICALS by RIDDICK, David S, LEE, Chunja, CHIANG, John Y. L, BHATHENA, Anahita, TIMSIT, Yoav E, CHENG, Po-Yung, MORGAN, Edward T, PROUGH, Russell A, RIPP, Sharon L, MILLER, Kristy K, JAHAN, Asmeen

“…This article is an invited report of a symposium sponsored by the Division for Drug Metabolism of the American Society for Pharmacology and Experimental…”
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Stimulation of Hepatic Signal Transducer and Activator of Transcription 5b by GH Is Not Altered by 3-Methylcholanthrene by Timsit, Yoav E, Riddick, David S

“…We are investigating the mechanisms by which aromatic hydrocarbons, such as 3-methylcholanthrene (MC), suppress hepatic cytochrome P450 2C11 (CYP2C11) gene…”
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The U-box ligase carboxyl-terminus of Hsc 70-interacting protein ubiquitylates Epsin by Timsit, Yoav E., Miller, Stephanie L.H., Mohney, Robert P., O’Bryan, John P.

“…Epsin is an endocytic adaptor protein involved in the regulation of clathrin-dependent endocytosis. We and others have demonstrated that Epsin is ubiquitylated…”
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Aromatic Hydrocarbon Receptor Expression and Function in Liver of Hypophysectomized Male Rats by Timsit, Yoav E., Chia, Frank Shih-Chang, Bhathena, Anahita, Riddick, David S.

“…The aromatic hydrocarbon receptor (AHR) acts as a ligand-activated transcription factor that mediates many of the biological responses to aromatic…”
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The 2001 Veylien Henderson Award of the Society of Toxicology of Canada. Positive and negative transcriptional regulation of cytochromes P450 by polycyclic aromatic hydrocarbons by Riddick, David S, Lee, Chunja, Bhathena, Anahita, Timsit, Yoav E

“…Most responses to aromatic hydrocarbons such as 3-methylcholanthrene (MC) and 2,3,7,8-tetrachlorodibenzo-p-dioxin are mediated by the aromatic hydrocarbon…”
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Coordinated Regulation of Nuclear Receptor CAR by CCRP/DNAJC7, HSP70 and the Ubiquitin-Proteasome System: e96092 by Timsit, Yoav E, Negishi, Masahiko

“…The constitutive active/androstane receptor (CAR) plays an important role as a coordinate transcription factor in the regulation of various hepatic metabolic…”
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Nuclear translocation of CAR is dependent on ubiquitination and proteasome‐mediated degradation of CAR cytoplasmic retention protein (CCRP) by Timsit, Yoav E., Negishi, Masahiko

“…The constitutive active/androstane receptor (CAR) plays an important role as a coordinate transcription factor in the regulation of various hepatic metabolic…”
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Mitigating smoothened inhibitor-induced growth plate closure with parathyroid hormone by Timsit, Yoav E, Gunson, Diane E, Krucker, Thomas, Markovits, Judit E, Buonamici, Silvia, Boral, Anthony, Amakye, Dereck Dokyi, Nelson, Aaron L, Pognan, Francois, Chibout, Salah-Dine, Turner, Nancy A

“…Abstract only 9562 Background: The Hedgehog pathway plays an important role in regulating growth plate patency by activating PTH/PTHrP signaling, and loss of…”
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Characterization of anti-cytochrome P450 antibodies in patients with carbamazepine hypersensitivity reactions: A mechanistic study by Timsit, Yoav Ephraim

“…Hypersensitivity reactions to carbamazepine are characterized by the delayed onset (days to months after drug administration) of skin rash, lymphadenopathy and…”
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Interference with Growth Hormone Stimulation of Hepatic Cytochrome P4502C11 Expression in Hypophysectomized Male Rats by 3-Methylcholanthrene by Timsit, Yoav E., Riddick, David S.

“…Cytochrome P450 2C11 (CYP2C11) is a sexually dimorphic liver enzyme whose expression is regulated by the male pulsatile pattern of growth hormone (GH)…”
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