Search Results - "Timperley, Christopher M"

Bispyridinium Compounds Inhibit Both Muscle and Neuronal Nicotinic Acetylcholine Receptors in Human Cell Lines by Ring, Avi, Strom, Bjorn Oddvar, Turner, Simon R, Timperley, Christopher M, Bird, Michael, Green, A Christopher, Chad, John E, Worek, Franz, Tattersall, John E H

“…Standard treatment of poisoning by organophosphorus anticholinesterases uses atropine to reduce the muscarinic effects of acetylcholine accumulation and oximes…”
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Production of ES1 Plasma Carboxylesterase Knockout Mice for Toxicity Studies by Duysen, Ellen G, Koentgen, Frank, Williams, Gareth R, Timperley, Christopher M, Schopfer, Lawrence M, Cerasoli, Douglas M, Lockridge, Oksana

“…The LD50 for soman is 10–20-fold higher for a mouse than a human. The difference in susceptibility is attributed to the presence of carboxylesterase in mouse…”
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Investigative science and technology supporting the Organization for the Prohibition of Chemical Weapons (OPCW) by Borrett, Veronica, Timperley, Christopher M., Forman, Jonathan E., Tang, Cheng

“…The Chemical Weapons Convention (hereinafter 'the Convention'), an international disarmament and non-proliferation treaty, entered into force in 1997. It…”
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Influence of Experimental End Point on the Therapeutic Efficacy of Essential and Additional Antidotes in Organophosphorus Nerve Agent-Intoxicated Mice by Kassa, Jiri, Timperley, Christopher M, Bird, Mike, Green, A Christopher, Tattersall, John E H

“…The therapeutic efficacy of treatments for acute intoxication with highly toxic organophosphorus compounds, called nerve agents, usually involves determination…”
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Restoration of nerve agent impaired neuromuscular transmission in rat diaphragm by bispyridinium non-oximes – Structure-activity relationships by Amend, Niko, Timperley, Christopher M., Bird, Mike, Green, A. Christopher, Worek, Franz, Seeger, Thomas

“…Organophosphate (OP) poisoning is currently treated with atropine, oximes and benzodiazepines. The nicotinic signs, i.e., respiratory impairment, can only be…”
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Highest paraoxonase turnover rate found in a bacterial phosphotriesterase variant by Briseño-Roa, Luis, Oliynyk, Zoryana, Timperley, Christopher M., Griffiths, Andrew D., Fersht, Alan R.

“…The bacterial phosphotriesterase (PTE) catalyses the hydrolysis of the man-made pesticide paraoxon with a diffusion-limited efficiency. Here we describe the…”
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The use of bispyridinium non-oxime analogues for the restoration of nerve agent impaired neuromuscular transmission in rat hemidiaphragms – Structure optimization by Amend, Niko, Timperley, Christopher M., Bird, Mike, Green, A.Christopher, Worek, Franz, Seeger, Thomas

“…Organophosphate pesticide poisoning challenges health care systems worldwide. Furthermore, nerve agents remain a continuous threat. The treatment options for…”
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The risk associated with organophosphorus nerve agents: from their discovery to their unavoidable threat, current medical countermeasures and perspectives by Voros, Camille, Dias, José, Timperley, Christopher M., Nachon, Florian, Brown, Richard C.D., Baati, Rachid

“…The first organophosphorus nerve agent was discovered accidently during the development of pesticides, shortly after the first use of chemical weapons…”
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Reply to “Comment on ‘Nomenclature, Chemical Abstracts Service Numbers, Isomer Enumeration, Ring Strain, and Stereochemistry: What Does Any of This Have to Do with an International Chemical Disarmament and Nonproliferation Treaty?’” by Timperley, Christopher M, Forman, Jonathan E

“…A letter to this Journal provided useful comments and accurate enumerations of isomers for sets of organic compounds discussed in the paper “Nomenclature,…”
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Potency of irritation by benzylidenemalononitriles in humans correlates with TRPA1 ion channel activation by Lindsay, Christopher D., Green, Christopher, Bird, Mike, Jones, James T. A., Riches, James R., McKee, Katherine K., Sandford, Mark S., Wakefield, Debra A., Timperley, Christopher M.

“…We show that the physiological activity of solid aerosolized benzylidenemalononitriles (BMNs) including ‘tear gas’ (CS) in historic human volunteer trials…”
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Analysis of Clothing and Urine from Moscow Theatre Siege Casualties Reveals Carfentanil and Remifentanil Use by Riches, James R., Read, Robert W., Black, Robin M., Cooper, Nicholas J., Timperley, Christopher M.

“…On October 26, 2002, Russian Special Forces deployed a chemical aerosol against Chechen terrorists to rescue hostages in the Dubrovka theatre. Its use…”
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Biochemical and Structural Insights into FIH‐Catalysed Hydroxylation of Transient Receptor Potential Ankyrin Repeat Domains by Saward, Benjamin G., Leissing, Thomas M., Clifton, Ian J., Tumber, Anthony, Timperley, Christopher M., Hopkinson, Richard J., Schofield, Christopher J.

“…Transient receptor potential (TRP) channels have important roles in environmental sensing in animals. Human TRP subfamily A member 1 (TRPA1) is responsible for…”
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Molecular determinants of binding of non-oxime bispyridinium nerve agent antidote compounds to the adult muscle nAChR by Epstein, Max, Bali, Karan, Piggot, Thomas J., Green, A. Christopher, Timperley, Christopher M., Bird, Mike, Tattersall, John E.H., Bermudez, Isabel, Biggin, Philip C.

“…•Simulation of bispyridinium compounds at human nAChRs reveals interaction sites.•Longer bispyridiniums can also interact at an allosteric site.•Two-electrode…”
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Assessment of false transmitters as treatments for nerve agent poisoning by Whitmore, Charlotte, Lindsay, Christopher D., Bird, Mike, Gore, Samuel J., Rice, Helen, Williams, Rebecca L., Timperley, Christopher M., Green, A. Christopher

“…•AMECh and ADECh act as false transmitters at human acetylcholine receptors.•Administration of MECh and DECh led to recovery in a soman-exposed functional…”
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Nomenclature, Chemical Abstracts Service Numbers, Isomer Enumeration, Ring Strain, and Stereochemistry: What Does Any of This Have to Do with an International Chemical Disarmament and Nonproliferation Treaty? by Pontes, Giovanna, Schneider, Julieta, Brud, Peter, Benderitter, Lucas, Fourie, Bernhardt, Tang, Cheng, Timperley, Christopher M, Forman, Jonathan E

“…The Chemical Weapons Convention (CWC) is an international disarmament and nonproliferation treaty that mandates a comprehensive ban on chemical weapons. This…”
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Advice on assistance and protection provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 1. On medical care and treatment of injuries from nerve agents by Timperley, Christopher M., Forman, Jonathan E., Abdollahi, Mohammad, Al-Amri, Abdullah Saeed, Baulig, Augustin, Benachour, Djafer, Borrett, Veronica, Cariño, Flerida A., Geist, Michael, Gonzalez, David, Kane, William, Kovarik, Zrinka, Martínez-Álvarez, Roberto, Mourão, Nicia Maria Fusaro, Neffe, Slawomir, Raza, Syed K., Rubaylo, Valentin, Suárez, Alejandra Graciela, Takeuchi, Koji, Tang, Cheng, Trifirò, Ferruccio, van Straten, Francois Mauritz, Vanninen, Paula S., Vučinić, Slavica, Zaitsev, Volodymyr, Zafar-Uz-Zaman, Muhammad, Zina, Mongia Saïd, Holen, Stian

“…[Display omitted] •Work of the Organisation of the Prohibition of Chemical Weapons (OPCW) is described.•Advice on assistance and protection from OPCW…”
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Advice on assistance and protection from the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 2. On preventing and treating health effects from acute, prolonged, and repeated nerve agent exposure, and the identification of medical countermeasures able to reduce or eliminate the longer term health effects of nerve agents by Timperley, Christopher M, Abdollahi, Mohammad, Al-Amri, Abdullah Saeed, Baulig, Augustin, Benachour, Djafer, Borrett, Veronica, Cariño, Flerida A, Geist, Michael, Gonzalez, David, Kane, William, Kovarik, Zrinka, Martínez-Álvarez, Roberto, Fusaro Mourão, Nicia Maria, Neffe, Slawomir, Raza, Syed K, Rubaylo, Valentin, Suárez, Alejandra Graciela, Takeuchi, Koji, Tang, Cheng, Trifirò, Ferruccio, van Straten, Francois Mauritz, Vanninen, Paula S, Vučinić, Slavica, Zaitsev, Volodymyr, Zafar-Uz-Zaman, Muhammad, Zina, Mongia Saïd, Holen, Stian, Forman, Jonathan E, Alwan, Wesam S, Suri, Vivek

“…The Scientific Advisory Board (SAB) of the Organisation for the Prohibition of Chemical Weapons (OPCW) has provided advice in relation to the Chemical Weapons…”
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Metal-organic frameworks: Breaking bad chemicals down by Rosseinsky, Matthew J, Smith, Martin W, Timperley, Christopher M

“…Writing in Nature Materials, Joseph Mondloch and co-workers now report a way to destroy chemical warfare agents using a porous metal-organic framework (MOF)…”
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3-Quinuclidinyl-α-methoxydiphenylacetate: A multi-targeted ligand with antimuscarinic and antinicotinic effects designed for the treatment of anticholinesterase poisoning by Timperley, Christopher M., Bird, Mike, Gore, Samuel J., Lindsay, Christopher D., Rice, Helen, Tattersall, John E.H., Whitmore, Charlotte L., Green, A. Christopher

“…[Display omitted] •Racemic 3-quinuclidinyl-α-methyldiphenylacetate (MB266) was synthesised.•Action at muscarinic, muscle/neuronal nicotinic, acetylcholine…”
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Advice on assistance and protection provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 3. On medical care and treatment of injuries from sulfur mustard by Timperley, Christopher M., Forman, Jonathan E., Abdollahi, Mohammad, Al-Amri, Abdullah Saeed, Baulig, Augustin, Benachour, Djafer, Borrett, Veronica, Cariño, Flerida A., Curty, Christophe, Geist, Michael, Gonzalez, David, Kane, William, Kovarik, Zrinka, Martínez-Álvarez, Roberto, Mourão, Nicia Maria Fusaro, Neffe, Slawomir, Raza, Syed K., Rubaylo, Valentin, Suárez, Alejandra Graciela, Takeuchi, Koji, Tang, Cheng, Trifirò, Ferruccio, van Straten, Francois Mauritz, Vanninen, Paula S., Vučinić, Slavica, Zaitsev, Volodymyr, Zafar-Uz-Zaman, Muhammad, Zina, Mongia Saïd, Holen, Stian, Alwan, Wesam S., Suri, Vivek, Hotchkiss, Peter J., Ghanei, Mostafa

“…[Display omitted] •Work of the Organisation of the Prohibition of Chemical Weapons (OPCW) is described.•Advice on assistance and protection from OPCW…”
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