Search Results - "Timothy J. Hoffman"

[⁶⁴Cu-NOTA-8-Aoc-BBN(7-14)NH₂] targeting vector for positron-emission tomography imaging of gastrin-releasing peptide receptor-expressing tissues by Prasanphanich, Adam F, Nanda, Prasant K, Rold, Tammy L, Ma, Lixin, Lewis, Michael R, Garrison, Jered C, Hoffman, Timothy J, Sieckman, Gary L, Figueroa, Said D, Smith, Charles J

“…Radiolabeled peptides hold promise as diagnostic/therapeutic targeting vectors for specific human cancers. We report the design and development of a targeting…”
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Chemistry and radiochemistry of As, Re and Rh isotopes relevant to radiopharmaceutical applications: high specific activity radionuclides for imaging and treatment by Feng, Yutian, Phelps, Tim E, Carroll, Valerie, Gallazzi, Fabio, Sieckman, Gary, Hoffman, Timothy J, Barnes, Charles L, Ketring, Alan R, Hennkens, Heather M, Jurisson, Silvia S

“…The chemistry and radiochemistry of high specific activity radioisotopes of arsenic, rhenium and rhodium are reviewed with emphasis on University of Missouri…”
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Synthesis and preclinical evaluation of a novel fluorine-18 labeled small-molecule PET radiotracer for imaging of CXCR3 receptor in mouse models of atherosclerosis by Alluri, Santosh R., Higashi, Yusuke, Berendzen, Ashley, Grisanti, Laurel A., Watkinson, Lisa D., Singh, Kamlendra, Hoffman, Timothy J., Carmack, Terry, Devanny, Elizabeth A., Tanner, Miles, Kil, Kun-Eek

“…Background CXCR3 is a chemokine receptor and is expressed in innate and adaptive immune cells. It promotes the recruitment of T-lymphocytes and other immune…”
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Characterization and evaluation of DOTA-conjugated Bombesin/RGD-antagonists for prostate cancer tumor imaging and therapy by Stott Reynolds, Tamila J, Schehr, Rebecca, Liu, Dijie, Xu, Jingli, Miao, Yubin, Hoffman, Timothy J, Rold, Tammy L, Lewis, Michael R, Smith, Charles J

“…Abstract Introduction Here we present the metallation, characterization, in vivo and in vitro evaluations of dual-targeting, peptide-based radiopharmaceuticals…”
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Optimization, biological evaluation and microPET imaging of copper-64-labeled bombesin agonists, [64 Cu-NO2A-(X)-BBN(7–14)NH2 ], in a prostate tumor xenografted mouse model by Lane, Stephanie R, Nanda, Prasanta, Rold, Tammy L, Sieckman, Gary L, Figueroa, Said D, Hoffman, Timothy J, Jurisson, Silvia S, Smith, Charles J

“…Abstract Gastrin-releasing peptide receptors (GRPr) are a member of the bombesin (BBN) receptor family. GRPr are expressed in high numbers on specific human…”
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Evidence for the Influence of Diet on Cranial Form and Robusticity by Menegaz, Rachel A., Sublett, Samantha V., Figueroa, Said D., Hoffman, Timothy J., Ravosa, Matthew J., Aldridge, Kristina

“…The evolutionary significance of cranial form and robusticity in early Homo has been variously attributed to allometry, encephalization, metabolic factors,…”
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Evaluation of [99mTc-(CO)3-X-Y-Bombesin(7-14)NH2] Conjugates for Targeting Gastrin-releasing Peptide Receptors Overexpressed on Breast Carcinoma by RETZLOFF, Lauren B, HEINZKE, Laura, FIGUREOA, Said D, SUBLETT, Samantha V, LIXIN MA, SIECKMAN, Gary L, ROLD, Tammy L, SANTOS, Isabel, HOFFMAN, Timothy J, SMITH, Charles J

“…Background: Gastrin-releasing peptide (GRP) receptors are overexpressed on a variety of human carcinomas, including those of the breast. These receptors may be…”
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In Vivo Imaging of Human Colorectal Cancer Using Radiolabeled Analogs of the Uroguanylin Peptide Hormone by DIJIE LIU, OVERBEY, Douglas, WATKINSON, Lisa D, DAIBES-FIGUEROA, Said, HOFFMAN, Timothy J, FORTE, Leonard R, VOLKERT, Wynn A, GIBLIN, Michael F

“…Background: Uroguanylin is an endogenous peptide agonist that binds to the guanylate cyclase C receptor (GC-C). GC-C is overexpressed in human colorectal…”
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Bombesin Peptide Conjugated Gold Nanocages Internalize via Clathrin Mediated Endocytosis by Suresh, Dhananjay, Zambre, Ajit, Chanda, Nripen, Hoffman, Timothy J, Smith, C. Jeffrey, Robertson, J. David, Kannan, Raghuraman

“…The nature of interaction and mechanism of internalization of receptor-avid peptide nanoparticles with cells is not yet completely understood. This article…”
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Investigation of neutron shielding materials for low-background gamma spectrometry by Khan, Abdul J., Li, Xin, Haines, Douglas K., Hoffman, Timothy J., Semkow, Thomas M.

“…In gamma spectrometers located at ground-level or in shallow-underground laboratories, muon-induced neutrons contribute significantly to the background. We…”
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Microimaging Characterization of a B16-F10 Melanoma Metastasis Mouse Model by Winkelmann, Christopher T., Figueroa, Said Daibes, Rold, Tammy L., Volkert, Wynn A., Hoffman, Timothy J.

“…Metastatic mouse models of melanoma have been characterized by gross necropsy examination, histopathology, and optical imaging. To determine if the time…”
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A New, Second Generation Trithiol Bifunctional Chelate for 72,77 As: Trithiol(b)-(Ser) 2 -RM2 by Najafi Khosroshahi, Firouzeh, Feng, Yutian, Ma, Li, Manring, Simon, Rold, Tammy L, Gallazzi, Fabio A, Kelley, Steven P, Embree, Mary F, Hennkens, Heather M, Hoffman, Timothy J, Jurisson, Silvia S

“…Trithiol chelates are suitable for labeling radioarsenic ( As: 2.49 MeV β , 26 h; As: 0.683 MeV β , 38.8 h) to form potential theranostic radiopharmaceuticals…”
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Gamma Radioactivity Detection Limits and Associated Radionuclide Intakes Study in Artificial Human Urine Using Sodium-iodide and High-purity Germanium Detectors by Burn, Adam G., Haines, Douglas K., Khan, Abdul J., Torres, Miguel A., Faye, Sherry A., Costello, Cynthia A., Hoffman, Timothy J., Chu, Liang T., Bradt, Clayton J., Semkow, Thomas M.

“…The performance of several gamma detectors was investigated for emergency urine bioassay screening of two radionuclides of concern: 131 I and 137 Cs. Unspiked…”
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Near-infrared fluorescence imaging of gastrin releasing peptide receptor targeting in prostate cancer lymph node metastases by Cai, Quan-Yu, Yu, Ping, Besch-Williford, Cynthia, Smith, Charles J., Sieckman, Gary L., Hoffman, Timothy J., Ma, Lixin

“…BACKGROUND Development of high affinity and specificity molecular imaging probes that increase accuracy for early detection of lymph node (LN) metastases is…”
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Evaluation of the Pharmacokinetic Effects of Various Linking Group Using the 111In-DOTA-X-BBN(7−14)NH2 Structural Paradigm in a Prostate Cancer Model by Garrison, Jered C, Rold, Tammy L, Sieckman, Gary L, Naz, Farah, Sublett, Samantha V, Figueroa, Said Daibes, Volkert, Wynn A, Hoffman, Timothy J

“…The high incidence of BB2 receptor (BB2r) expression in various cancers has prompted investigators to pursue the development of BB2r-targeted agents for…”
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True radiotracers: Cu-64 targeting vectors based upon bombesin peptide by Hoffman, Timothy J, Smith, Charles J

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Therapeutic Radiopharmaceuticals by Volkert, Wynn A., Hoffman, Timothy J.

“…Volkert and Hoffman discuss some of the considerations involved in identifying the radionuclides that hold potential for the development of radioactive…”
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Synthesis and biological evaluation of copper-64 radiolabeled [DUPA-6-Ahx-(NODAGA)-5-Ava-BBN(7-14)NH2 ], a novel bivalent targeting vector having affinity for two distinct biomarkers (GRPr/PSMA) of prostate cancer by Bandari, Rajendra Prasad, Jiang, Zongrun, Reynolds, Tamila Stott, Bernskoetter, Nicole E, Szczodroski, Ashley F, Bassuner, Kurt J, Kirkpatrick, Daniel L, Rold, Tammy L, Sieckman, Gary L, Hoffman, Timothy J, Connors, James P, Smith, Charles J

“…Abstract Gastrin-releasing peptide receptors (GRPr) and prostate-specific membrane antigen (PSMA) are two identifying biomarkers expressed in very high numbers…”
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Selective Targeting of E. coli Heat-stable Enterotoxin Analogs to Human Colon Cancer Cells by GIBLIN, Michael F, SIECKMAN, Gary L, WATKINSON, Lisa D, DAIBES-FIGUEROA, Said, HOFFMAN, Timothy J, FORTE, Leonard R, VOLKERT, Wynn A

“…Background: Radiolabeled analogs of the E. coli heat-stable enterotoxin (ST h ) are currently under study as imaging and therapeutic agents for colorectal…”
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The Effects of Linking Substituents on the In Vivo Behavior of Site-directed, Peptide-based, Diagnostic Radiopharmaceuticals by Prasanphanich, Adam F, Lane, Stephanie R, Figueroa, Said D, Ma, Lixin, Rold, Tammy L, Sieckman, Gary L, Hoffman, Timothy J, McCrate, Joseph M, Smith, Charles J

“…A number of human cancers are known to over-express the gastrin-releasing peptide receptor (GRPr) on cell surfaces. The high specificity and affinity of…”
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