Search Results - "Timms, K"

Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer by Abkevich, V, Timms, K M, Hennessy, B T, Potter, J, Carey, M S, Meyer, L A, Smith-McCune, K, Broaddus, R, Lu, K H, Chen, J, Tran, T V, Williams, D, Iliev, D, Jammulapati, S, FitzGerald, L M, Krivak, T, DeLoia, J A, Gutin, A, Mills, G B, Lanchbury, J S

“…Background: Defects in BRCA1 , BRCA2 , and other members of the homologous recombination pathway have potential therapeutic relevance when used to support…”
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TBCRC 030: a phase II study of preoperative cisplatin versus paclitaxel in triple-negative breast cancer: evaluating the homologous recombination deficiency (HRD) biomarker by Mayer, E.L., Abramson, V., Jankowitz, R., Falkson, C., Marcom, P.K., Traina, T., Carey, L., Rimawi, M., Specht, J., Miller, K., Stearns, V., Tung, N., Perou, C., Richardson, A.L., Componeschi, K., Trippa, L., Tan-Wasielewski, Z., Timms, K., Krop, I., Wolff, A.C., Winer, E.P.

“…Cisplatin and paclitaxel are active in triple-negative breast cancer (TNBC). Despite different mechanisms of action, effective predictive biomarkers to…”
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Survival analysis of carboplatin added to an anthracycline/taxane-based neoadjuvant chemotherapy and HRD score as predictor of response—final results from GeparSixto by Loibl, S., Weber, K.E., Timms, K.M., Elkin, E.P., Hahnen, E., Fasching, P.A., Lederer, B., Denkert, C., Schneeweiss, A., Braun, S., Salat, C.T., Rezai, M., Blohmer, J.U., Zahm, D.M., Jackisch, C., Gerber, B., Klare, P., Kümmel, S., Schem, C., Paepke, S., Schmutzler, R., Rhiem, K., Penn, S., Reid, J., Nekljudova, V., Hartman, A.-R., von Minckwitz, G., Untch, M.

“…In the neoadjuvant GeparSixto study, adding carboplatin to taxane- and anthracycline-based chemotherapy improved pathological complete response (pCR) rates in…”
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Analysis of mutation status and homologous recombination deficiency in tumors of patients with germline BRCA1 or BRCA2 mutations and metastatic breast cancer: OlympiAD by Hodgson, D., Lai, Z., Dearden, S., Barrett, J.C., Harrington, E.A., Timms, K., Lanchbury, J., Wu, W., Allen, A., Senkus, E., Domchek, S.M., Robson, M.

“…Presence of a germline BRCA1 and/or BRCA2 mutation (gBRCAm) may sensitize tumors to poly(ADP-ribose) polymerase (PARP) inhibition via inactivation of the…”
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Impact of homologous recombination deficiency biomarkers on outcomes in patients with triple-negative breast cancer treated with adjuvant doxorubicin and cyclophosphamide (SWOG S9313) by Sharma, P., Barlow, W.E., Godwin, A.K., Pathak, H., Isakova, K., Williams, D., Timms, K.M., Hartman, A.R., Wenstrup, R.J., Linden, H.M., Tripathy, D., Hortobagyi, G.N., Hayes, D.F.

“…Homologous recombination deficiency (HRD)-causing alterations have been reported in triple-negative breast cancer (TNBC). We hypothesized that TNBCs with HRD…”
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Breast cancer brain metastases show increased levels of genomic aberration-based homologous recombination deficiency scores relative to their corresponding primary tumors by Diossy, M., Reiniger, L., Sztupinszki, Z., Krzystanek, M., Timms, K.M., Neff, C., Solimeno, C., Pruss, D., Eklund, A.C., Tóth, E., Kiss, O., Rusz, O., Cserni, G., Zombori, T., Székely, B., Kulka, J., Tímár, J., Csabai, I., Szallasi, Z.

“…Based on its mechanism of action, PARP inhibitor therapy is expected to benefit mainly tumor cases with homologous recombination deficiency (HRD). Therefore,…”
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World Endometriosis Society consensus on the classification of endometriosis by Johnson, Neil P., Hummelshoj, Lone, Adamson, G. David, Keckstein, Jörg, Taylor, Hugh S., Abrao, Mauricio S., Bush, Deborah, Kiesel, Ludwig, Tamimi, Rulla, Sharpe-Timms, Kathy L., Rombauts, Luk, Giudice, Linda C., Abrao, Mauricio, Adamson, G. David, Advincula, Arnold, Allaire, Catherine, Andersson, Elisabet, Arche, Joan-Carles, Becker, Christian, Bush, Deborah, Chwalisz, Kristof, Condous, George, Critchley, Hilary, de Bie, Bianca, D'Hooghe, Thomas, Dunselman, Gerard, Evers, Johannes (Hans), Farquhar, Cindy, Faustmann, Thomas, Ferriani, Rui, Flores, Idhalez, Forman, Axel, Fourquet, Jessica, Fraser, Ian, Giudice, Linda, Guidone, Heather, Guo, Sun-Wei, Hull, Louise, Hummelshoj, Lone, Johnson, Neil, Keckstein, Jorg, Kiesel, Ludwig, Koninckx, Philippe, Lam, Alan, Lessey, Bruce, Maher, Peter, Marcellin, Louis, Marriott, Joy, Menakaya, Uche, Missmer, Stacey, Mol, Ben, Nisenblat, Vicki, Paredes, Dana, Petta, Carlos, Reis, Fernando, Rolla, Edgardo, Rombauts, Luk, Seckin, Tamer, Sharpe Timms, Kathy, Soriano, David, Stratton, Pamela, Tamimi, Rulla, Taylor, Hugh, Taylor, Robert, Tsaltas, Jim, Verhagen-Kamberbeek, Wilma, Zondervan, Krina

“…Abstract STUDY QUESTION What is the global consensus on the classification of endometriosis that considers the views of women with endometriosis? SUMMARY…”
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Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis by CAPON, Francesca, DI MEGLIO, Paola, LANCHBURY, Jerry, BARKER, Jonathan N, TREMBATH, Richard C, NESTLE, Frank O, SZAUB, Joanna, PRESCOTT, Natalie J, DUNSTER, Christina, BAUMBER, Laura, TIMMS, Kirsten, GUTIN, Alexander, ABKEVIC, Victor, BURDEN, A. David

“…Psoriasis is an inflammatory skin disorder that is inherited as a multifactorial trait. Genetic analyses have repeatedly identified a primary disease…”
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Dehydroepiandrosterone replacement in aging humans by FLYNN, M. A, WEAVER-OSTERHOLTZ, D, SHARPE-TIMMS, K. L, ALLEN, S, KRAUSE, G

“…Because so much medical and media attention has been drawn to the alleged benefits of dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS), it is…”
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Inflammatory cytokines differentially up-regulate human endometrial haptoglobin production in women with endometriosis by Sharpe-Timms, K.L., Nabli, H., Zimmer, R.L., Birt, J.A., Davis, J.W.

“…BACKGROUND Evidence suggests that eutopic endometrium from women with endometriosis (US-E) has intrinsic functional anomalies compared with women without…”
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HLA-G is expressed by the glandular epithelium of peritoneal endometriosis but not in eutopic endometrium by Barrier, B.F., Kendall, B.S., Ryan, C.E., Sharpe-Timms, K.L.

“…BACKGROUND: HLA-G is a major histocompatability antigen with documented immune-regulatory function. Various epithelial cancers and tissue allografts have been…”
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466 Next generation sequencing of BRCA1 and BRCA2 genes in ovarian tumors captures all germline mutations and expands the potential treatment group for the PARP inhibitor olaparib by Timms, K, Neff, C, Morris, B, Hodgson, D, Orr, M, Zhongwu, L, Fielding, A, Dougherty, B, Spencer, S, Robertson, J, Barrett, C, Gutin, A, Lanchbury, J

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458 DNA repair deficiencies in ovarian cancer: Genomic analysis of high grade serous ovarian tumors from the NOVA study by Timms, K, Neff, C, Abkevich, V, Jones, J.T, Kolquist, K.A, Mirza, M, Lanchbury, J, Mikule, K, Agarwal, S, Hartman, A.R, Gutin, A, Wilcoxen, K

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435 Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes by Hodgson, D.R, Dougherty, B, Lai, Z, Grinsted, L, Spencer, S, O'Connor, M.J, Ho, T.W, Robertson, J.D, Lanchbury, J, Timms, K, Gutin, A, Orr, M, Jones, H, Gilks, B, Womack, C, Sun, J, Yelensky, R, Gourley, C, Ledermann, J, Barrett, J.C

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Genomic DNA pooling for whole-genome association scans in complex disease: empirical demonstration of efficacy in rheumatoid arthritis by Steer, S, Abkevich, V, Gutin, A, Cordell, H J, Gendall, K L, Merriman, M E, Rodger, R A, Rowley, K A, Chapman, P, Gow, P, Harrison, A A, Highton, J, Jones, P B B, O'Donnell, J, Stamp, L, Fitzgerald, L, Iliev, D, Kouzmine, A, Tran, T, Skolnick, M H, Timms, K M, Lanchbury, J S, Merriman, T R

“…A pragmatic approach that balances the benefit of a whole-genome association (WGA) experiment against the cost of individual genotyping is to use pooled…”
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Differential Regulation of Matrix Metalloproteinase-3 Gene Expression in Endometriotic Lesions Compared with Endometrium by Cox, K E, Piva, M, Sharpe-Timms, K L

“…In vivo levels of mRNA and the specificity of the extrauterine environment on matrix metalloproteinase (MMP)-3, MMP-2, and tissue inhibitor of matrix…”
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Differential expression and localization of de-novo synthesized endometriotic haptoglobin in endometrium and endometriotic lesions by Sharpe-Timms, K.L., Ricke, E.A., Piva, M., Horowitz, G.M.

“…Endometriosis protein-I (ENDO-I) mRNA expression and protein localization were evaluated using in-situ hybridization and immunohistochemistry in endometriotic…”
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A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree by TIMMS, Kirsten M, WAGNER, Susanne, SAMUELS, Mark E, FORBEY, Kristian, GOLDFINE, Howard, JAMMULAPATI, Srikanth, SKOLNICK, Mark H, HOPKINS, Paul N, HUNT, Steve C, SHATTUCK, Donna M

“…Familial hypercholesterolemia results from mutations in the low-density lipoprotein (LDL) receptor or apolipoprotein B genes. We have previously reported the…”
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Endometrial Anomalies in Women with Endometriosis by SHARPE-TIMMS, KATHY L.

“…Endometriotic lesions are defined by extrauterine growth of endometrial glands and stroma. Retrograde menstruation with subsequent attachment, invasion, and…”
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Tissue inhibitor of metalloproteinase-1 concentrations are attenuated in peritoneal fluid and sera of women with endometriosis and restored in sera by gonadotropin-releasing hormone agonist therapy by Sharpe-Timms, K L, Keisler, L W, McIntush, E W, Keisler, D H

“…To establish tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations in peritoneal fluid (PF) and sera of women with endometriosis and compare them to…”
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