Search Results - "Timmons, Shannon C"

Non‐enzymatic glycation reduces glucose transport in the human cartilage endplate independently of matrix porosity or proteoglycan content by Jung, Jae‐Young, Habib, Mohamed, Morrissette, Luke J., Timmons, Shannon C., Maerz, Tristan, Fields, Aaron J.

“…Background Intervertebral disc degeneration is associated with low back pain, which is a leading cause of disability. While the precise causes of disc…”
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Stereoselective Chemical Synthesis of Sugar Nucleotides via Direct Displacement of Acylated Glycosyl Bromides by Timmons, Shannon C, Jakeman, David L

“…The use of Leloir glycosyltransferases to prepare biologically relevant oligosaccharides and glycoconjugates requires access to sugar nucleoside diphosphates,…”
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Increasing carbohydrate diversity via amine oxidation: aminosugar, hydroxyaminosugar, nitrososugar, and nitrosugar biosynthesis in bacteria by Timmons, Shannon C, Thorson, Jon S

“…Bacterial secondary metabolites often contain carbohydrate attachments that play a significant role in conferring biological activity. A small proportion of…”
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Molecules in Medicine: A Week-Long Multidisciplinary Summer Camp for High School Students by Timmons, Shannon C., Kuzmanov, Aleksandra

“…Health-related career goals are popular among high school science students, yet few understand the application of chemistry and biology research to the field…”
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Effects of bisphenol A, bisphenol S, and tetramethyl bisphenol F on male fertility in Caenorhabditis elegans by Higley, Cole M, Waligora, Katelyn D, Clore, Jessica R, Timmons, Shannon C, Kuzmanov, Aleksandra

“…Research has shown that exposure to bisphenol A (BPA), a widely used plasticizer, can lead to meiotic errors, resulting in poor reproductive cell quality and…”
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Cancer and chemicals: A research‐inspired laboratory exercise based on the Ames test for mutagenicity by Large, Delaney N., Van Doorn, Nathaniel A., Timmons, Shannon C.

“…Laboratory courses should cultivate enthusiasm for research and an appreciation for real‐world scientific challenges to retain undergraduate students and…”
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Synthesis of α‑Deoxymono and Difluorohexopyranosyl 1‑Phosphates and Kinetic Evaluation with Thymidylyl- and Guanidylyltransferases by Zhu, Jian-She, McCormick, Nicole E, Timmons, Shannon C, Jakeman, David L

“…Eight fluorinated isosteric α-d-glucopyranosyl 1-phosphate (Glc 1P) analogues have been synthesized. A promiscuity investigation of the thymidylyltransferase…”
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Synthesis and reproductive toxicity of bisphenol A analogs with cyclic side chains in Caenorhabditis elegans by Roberts, Andrew H, Bowen, John E, Zhou, Xinrui, Burke, Isabella, Wenaas, Maxwell H, Blake, Timothy A, Timmons, Shannon C, Kuzmanov, Aleksandra

“…Accumulating evidence has shown that bisphenol A (BPA) affects not only the growth and development of reproductive tissues but also disrupts meiosis. Meiotic…”
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Nondestructive, indirect assessment of the biomechanical properties of the rat intervertebral disc using contrast‐enhanced μCT by Newton, Michael D., Hartner, Samantha E., Gawronski, Karissa, Davenport, Erik J., Timmons, Shannon C., Baker, Kevin C., Maerz, Tristan

“…ABSTRACT Mechanical characterization of the intervertebral disc involves labor‐intensive and destructive experimental methodology. Contrast‐enhanced…”
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Stereospecific synthesis of sugar-1-phosphates and their conversion to sugar nucleotides by Timmons, Shannon C., Jakeman, David L.

“…As Leloir glycosyltransferases are increasingly being used to prepare oligosaccharides, glycoconjugates, and glycosylated natural products, efficient access to…”
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Warfarin Glycosylation Invokes a Switch from Anticoagulant to Anticancer Activity by Peltier-Pain, Pauline, Timmons, Shannon C., Grandemange, Agnès, Benoit, Etienne, Thorson, Jon S.

“…Changing lanes! Glycosylation of the classical pharmacophore warfarin fundamentally alters the drug's mechanism‐of‐action, leading to a dramatic reduction in…”
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Exploiting Nucleotidylyltransferases To Prepare Sugar Nucleotides by Timmons, Shannon C, Mosher, Roy H, Knowles, Sheryl A, Jakeman, David L

“…Enzymatic approaches to prepare sugar nucleotides are gaining in importance and offer several advantages over chemical synthesis including high yields and…”
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On the synthesis of the 2,6-dideoxysugar l-digitoxose by Timmons, Shannon C., Jakeman, David L.

“…As deoxysugars are integral components of many natural products, the development of efficient chemical and enzymatic routes to prepare these compounds is of…”
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Expression, purification, and characterization of a carbohydrate‐active enzyme: A research‐inspired methods optimization experiment for the biochemistry laboratory by Willbur, Jaime F., Vail, Justin D., Mitchell, Lindsey N., Jakeman, David L., Timmons, Shannon C.

“…The development and implementation of research‐inspired, discovery‐based experiences into science laboratory curricula is a proven strategy for increasing…”
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Enzyme-Catalyzed Synthesis of Furanosyl Nucleotides by Timmons, Shannon C, Hui, Joseph P. M, Pearson, Jessica L, Peltier, Pauline, Daniellou, Richard, Nugier-Chauvin, Caroline, Soo, Evelyn C, Syvitski, Ray T, Ferrières, Vincent, Jakeman, David L

“…A bacterial α-d-glucopyranosyl-1-phosphate thymidylyltransferase was found to couple four hexofuranosyl-1-phosphates, as well as a pentofuranosyl-1-phosphate,…”
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Substrate flexibility of a 2,6-dideoxyglycosyltransferase by Jakeman, David L, Borissow, Charles N, Graham, Cathy L, Timmons, Shannon C, Reid, Taryn R, Syvitski, Ray T

“…We report the first 2,6-dideoxysugar-O-glycosyltransferase with substrate flexibility at the 2 position, confirm the function of a putative NDP-hexose…”
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Novel jadomycins: incorporation of non-natural and natural amino acids by Jakeman, David L., Farrell, Spring, Young, Wendy, Doucet, René J., Timmons, Shannon C.

“…[Display omitted] Electrospray ionization mass spectrometry of extracts from Streptomyces venezuelae ISP5230 cultures grown on chemically synthesized…”
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Enzyme-Catalyzed Synthesis of Furanosyl Nucleotides by Timmons, Shannon C, Hui, Joseph P. M, Pearson, Jessica L, Peltier, Pauline, Daniellou, Richard, Nugier-Chauvin, Caroline, Soo, Evelyn C, Syvitski, Ray T, Ferrières, Vincent, Jakeman, David L

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Stereoselective synthesis of sugar nucleotides using neighboring group participation by Timmons, Shannon C, Jakeman, David L

“…A straightforward, efficient method for the chemical synthesis of sugar nucleotides derived from D-mannose and L-fucose precursors is described. This synthetic…”
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Synthesis of Aspirin Analogs for Anticancer and Antibacterial Testing by Sleda, Melissa A., Albasrawi, Hadeel K., Timmons, Shannon C.

“…Aspirin is a common over‐the‐counter drug used to treat pain, fever, and inflammation. It is one of the most widely used medications in the world with an…”
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