Search Results - "Timmler, Burkhard"

Helicase–Primase Inhibitor Pritelivir for HSV-2 Infection by Wald, Anna, Corey, Lawrence, Timmler, Burkhard, Magaret, Amalia, Warren, Terri, Tyring, Stephen, Johnston, Christine, Kriesel, John, Fife, Kenneth, Galitz, Lawrence, Stoelben, Susanne, Huang, Meei-Li, Selke, Stacy, Stobernack, Hans-Peter, Ruebsamen-Schaeff, Helga, Birkmann, Alexander

“…New treatments are needed for herpes simplex virus infection. In this placebo-controlled, randomized, dose-ranging trial, pritelivir, an inhibitor of the viral…”
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Discovery, Chemistry, and Preclinical Development of Pritelivir, a Novel Treatment Option for Acyclovir-Resistant Herpes Simplex Virus Infections by Birkmann, Alexander, Bonsmann, Susanne, Kropeit, Dirk, Pfaff, Tamara, Rangaraju, Manickam, Sumner, Melanie, Timmler, Burkhard, Zimmermann, Holger, Buschmann, Helmut, Ruebsamen-Schaeff, Helga

“…When the nucleoside analogue acyclovir was introduced in the early 1980s, it presented a game-changing treatment modality for herpes simplex virus infections…”
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Effect of Pritelivir Compared With Valacyclovir on Genital HSV-2 Shedding in Patients With Frequent Recurrences: A Randomized Clinical Trial by Wald, Anna, Timmler, Burkhard, Magaret, Amalia, Warren, Terri, Tyring, Stephen, Johnston, Christine, Fife, Kenneth, Selke, Stacy, Huang, Meei-Li, Stobernack, Hans-Peter, Zimmermann, Holger, Corey, Lawrence, Birkmann, Alexander, Ruebsamen-Schaeff, Helga

“…IMPORTANCE: Current therapy of herpes infections relies on nucleoside analogues. Pritelivir is a well-tolerated novel herpes simplex virus (HSV)…”
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A Multicenter Assessment of the Outcomes and Toxicities of Foscarnet for Treatment of Acyclovir-Resistant Mucocutaneous Herpes Simplex in Immunocompromised Patients by Hammond, Sarah P, Rangaraju, Manickam, Sumner, Melanie, Timmler, Burkhard, Chandrasekar, Pranatharthi, Avery, Robin K

“…Abstract Background Acyclovir-resistant mucocutaneous herpes simplex virus (HSV) infection is an uncommon problem typically seen in immunocompromised hosts…”
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Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes by Schiffer, Joshua T, Swan, David A, Magaret, Amalia, Corey, Lawrence, Wald, Anna, Ossig, Joachim, Ruebsamen-Schaeff, Helga, Stoelben, Susanne, Timmler, Burkhard, Zimmermann, Holger, Melhem, Murad R, Van Wart, Scott A, Rubino, Christopher M, Birkmann, Alexander

“…Pharmacokinetic and pharmacodynamic models estimate the potency of antiviral agents but do not capture viral and immunologic factors that drive the natural…”
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No Evidence of Pritelivir Resistance Among Herpes Simplex Virus Type 2 Isolates After 4 Weeks of Daily Therapy by Edlefsen, Paul T., Birkmann, Alexander, Huang, Meei-Li, Magaret, Craig A., Kee, Jia Jin, Diem, Kurt, Goldner, Thomas, Timmler, Burkhard, Stoelben, Susanne, Ruebsamen-Schaeff, Helga, Zimmermann, Holger, Warren, Terri, Wald, Anna, Corey, Lawrence

“…Background, Pritelivir is a novel helicase-primase inhibitor in clinical development for treatment of herpes simplex virus type 2 (HSV-2) infections. In…”
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