Search Results - "Timmins, M."

Increased Cellular Free Cholesterol in Macrophage-specific Abca1 Knock-out Mice Enhances Pro-inflammatory Response of Macrophages by Zhu, Xuewei, Lee, Ji-Young, Timmins, Jenelle M., Brown, J. Mark, Boudyguina, Elena, Mulya, Anny, Gebre, Abraham K., Willingham, Mark C., Hiltbold, Elizabeth M., Mishra, Nilamadhab, Maeda, Nobuyo, Parks, John S.

“…Macrophage-specific Abca1 knock-out (Abca1–M/–M) mice were generated to determine the role of macrophage ABCA1 expression in plasma lipoprotein concentrations…”
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Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I by Timmins, Jenelle M, Lee, Ji-Young, Boudyguina, Elena, Kluckman, Kimberly D, Brunham, Liam R, Mulya, Anny, Gebre, Abraham K, Coutinho, Jonathan M, Colvin, Perry L, Smith, Thomas L, Hayden, Michael R, Maeda, Nobuyo, Parks, John S

“…Patients with Tangier disease exhibit extremely low plasma HDL concentrations resulting from mutations in the ATP-binding cassette, sub-family A, member 1…”
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Signal Transducer and Activator of Transcription-1 Is Critical for Apoptosis in Macrophages Subjected to Endoplasmic Reticulum Stress In Vitro and in Advanced Atherosclerotic Lesions In Vivo by LIM, Wah-Seng, TIMMINS, Jenelle M, SEIMON, Tracie A, SADLER, Anthony, KOLODGIE, Frank D, VIRMANI, Renu, TABAS, Ira

“…Macrophage apoptosis is a critical process in the formation of necrotic cores in vulnerable atherosclerotic plaques. In vitro and in vivo data suggest that…”
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Selecting a Cell Engineering Methodology During Cell Therapy Product Development by Timmins, Lauren M., Burr, Alexandra M., Carroll, Kristina, Keefe, Robert, Teryek, Matthew, Cantolupo, Louis J., van der Loo, Johannes C. M., Heathman, Thomas R.J., Gormley, Adam J, Smith, David, Parekkadan, Biju

“…When considering the development pathway for a genetically modified cell therapy product, it is critically important that the product is engineered consistent…”
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The CERN PIXE-RFQ, a transportable proton accelerator for the machina project by Mathot, S., Anelli, G., Atieh, S., Bilton, A., Bulat, B., Callamand, Th, Calvo, S., Favre, G., Geisser, J.-M., Gerardin, A., Grudiev, A., Lombardi, A., Montesinos, E., Motschmann, F., Pommerenke, H., Richerot, P., Scibor, K., Timmins, M., Vretenar, M., Taccetti, F., Benetti, F., Castelli, L., Chiari, M., Czelusniak, C., Falciano, S., Fedi, M., Mandò, P.A., Manetti, M., Matacotta, C., Previtali, E., Ruberto, C., Virgili, V., Giuntini, L.

“…CERN has been building a transportable RFQ for use in the examination of art masterpieces based mainly on the PIXE (Proton Induced X-ray Emission) technique…”
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Rapid identification of urinary tract infection bacteria using hyperspectral whole-organism fingerprinting and artificial neural networks by Goodacre, Royston, Timmins, eadaoin M, Burton, Rebecca, Kaderbhai, Naheed, Woodward, Andrew M, Kell, Douglas B, Rooney, Paul J

“…Institute of Biological Sciences, University of Wales, Aberystwyth, Ceredigion SY23 3DD, UK Bronglais General Hospital,Aberystwyth, Ceredigion SY23 lER, UK…”
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Tissue-Specific Roles of ABCA1 Influence Susceptibility to Atherosclerosis by BRUNHAM, Liam R, SINGARAJA, Roshni R, STAELS, Bart, PARKS, John S, HAYDEN, Michael R, DUONG, Myngan, TIMMINS, Jenelle M, FIEVET, Catherine, BISSADA, Nagat, KANG, Martin H, SAMRA, Amrit, FRUCHART, Jean-Charles, MCMANUS, Bruce

“…The ATP-binding cassette transporter, subfamily A, member 1 (ABCA1) plays a key role in HDL cholesterol metabolism. However, the role of ABCA1 in modulating…”
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Progress and R/D challenges for FCC-ee SRF by Venturini Delsolaro, W., Garlasche, M., Peauger, F., Rosaz, G., Karpov, I., Zhang, L., Valente Feliciano, A. M., Udongwo, S. A., Bianchi, A., Bellini, G., Ferrera, L. M. A., Pereira Carlos, C., Vega Cid, L., Leith, S., Proslier, T., Gorgi Zadeh, S., Timmins, M., Therasse, M., Koettig, T., Atieh, S., Brunner, O., Gerigk, F.

“…The FCC-ee machines present a huge challenge for the RF systems, which need to be adapted to very diverse beam conditions going from moderate energy and high…”
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Intestinal ABCA1 directly contributes to HDL biogenesis in vivo by Brunham, Liam R, Kruit, Janine K, Iqbal, Jahangir, Fievet, Catherine, Timmins, Jenelle M, Pape, Terry D, Coburn, Bryan A, Bissada, Nagat, Staels, Bart, Groen, Albert K, Hussain, M Mahmood, Parks, John S, Kuipers, Folkert, Hayden, Michael R

“…Plasma HDL cholesterol levels are inversely related to risk for atherosclerosis. The ATP-binding cassette, subfamily A, member 1 (ABCA1) mediates the…”
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High-gradient testing of an S -band, normal-conducting low phase velocity accelerating structure by Vnuchenko, A., Esperante Pereira, D., Gimeno Martinez, B., Benedetti, S., Catalan Lasheras, N., Garlasch, M., Grudiev, A., McMonagle, G., Pitman, S., Syratchev, I., Timmins, M., Wegner, R., Woolley, B., Wuensch, W., Faus Golfe, A.

“…A novel high-gradient accelerating structure with low phase velocity,v/c=0.38, has been designed, manufactured and high-power tested. The structure was…”
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Differentiation of Lactobacillus casei, Lactobacillus paracasei and Lactobacillus rhamnosus by polymerase chain reaction by Ward, L.J.H, Timmins, M.J

“…Lactobacillus casei, Lact. paracasei and Lact. rhamnosus form a closely related taxonomic group within the heterofermentative lactobacilli. These three species…”
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Targeted Deletion of Hepatocyte ABCA1 Leads to Very Low Density Lipoprotein Triglyceride Overproduction and Low Density Lipoprotein Hypercatabolism by Chung, Soonkyu, Timmins, Jenelle M., Duong, MyNgan, Degirolamo, Chiara, Rong, Shunxing, Sawyer, Janet K., Singaraja, Roshni R., Hayden, Michael R., Maeda, Nobuyo, Rudel, Lawrence L., Shelness, Gregory S., Parks, John S.

“…Loss of ABCA1 activity in Tangier disease (TD) is associated with abnormal apoB lipoprotein (Lp) metabolism in addition to the complete absence of high density…”
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Detection of the Dipicolinic Acid Biomarker in Bacillus Spores Using Curie-Point Pyrolysis Mass Spectrometry and Fourier Transform Infrared Spectroscopy by Goodacre, Royston, Shann, Beverley, Gilbert, Richard J, Timmins, Éadaoin M, McGovern, Aoife C, Alsberg, Bjørn K, Kell, Douglas B, Logan, Niall A

“…Thirty-six strains of aerobic endospore-forming bacteria confirmed by polyphasic taxonomic methods to belong to Bacillus amyloliquefaciens, Bacillus cereus,…”
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Design of the third-generation lead-based neutron spallation target for the neutron time-of-flight facility at CERN by Esposito, R., Calviani, M., Aberle, O., Barbagallo, M., Cano-Ott, D., Coiffet, T., Colonna, N., Domingo-Pardo, C., Dragoni, F., Franqueira Ximenes, R., Giordanino, L., Grenier, D., Gunsing, F., Kershaw, K., Logé, R., Maire, V., Moyret, P., Perez Fontenla, A., Perillo-Marcone, A., Pozzi, F., Sgobba, S., Timmins, M., Vlachoudis, V.

“…The neutron time-of-flight (n_TOF) facility at the European Laboratory for Particle Physics (CERN) is a pulsed white-spectrum neutron spallation source…”
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Investigating dynamics of lentiviral vector secretion from HEK293T producer cells using a fractionated perfusion system by Timmins, Lauren M., Erickson, Patrick, Parekkadan, Biju

“…Mammalian cell culture is quickly becoming the go to engineering vehicle to mass produce viral vectors in a manner that is safe, convenient, reproducible, and…”
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Rapid differentiation of closely related Candida species and strains by pyrolysis-mass spectrometry and Fourier transform-infrared spectroscopy by TIMMINS, E. M, HOWELL, S. A, ALSBERG, B. K, NOBLE, W. C, GOODACRE, R

“…Two rapid spectroscopic approaches for whole-organism fingerprinting of pyrolysis-mass spectrometry (PyMS) and Fourier transform-infrared spectroscopy (FT-IR)…”
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Movement of exotic plants into coastal native forests from gardens in northern New Zealand by Sullivan, Jon J., Timmins, Susan M., Williams, Peter A.

“…The number and abundance of exotic weeds in native forest fragments are known to correlate with the distance to the nearest large town. This is of concern as…”
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Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways by Timmins, Jenelle M, Ozcan, Lale, Seimon, Tracie A, Li, Gang, Malagelada, Cristina, Backs, Johannes, Backs, Thea, Bassel-Duby, Rhonda, Olson, Eric N, Anderson, Mark E, Tabas, Ira

“…ER stress-induced apoptosis is implicated in various pathological conditions, but the mechanisms linking ER stress-mediated signaling to downstream apoptotic…”
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Distribution and spread of environmental weeds along New Zealand roadsides by Sullivan, Jon J., Williams, Peter A., Timmins, Susan M., Smale, Mark C.

“…Most non-native weeds and other naturalised plants are in the early stages of invasion into New Zealand landscapes. For this invasion to be controlled, even…”
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Geometric Deep Learning using Vascular Surface Meshes for Modality-Independent Unruptured Intracranial Aneurysm Detection by Timmins, Kimberley M., Van der Schaaf, Irene C., Vos, Iris N., Ruigrok, Ynte M., Velthuis, Birgitta K., Kuijf, Hugo J.

“…Early detection of unruptured intracranial aneurysms (UIAs) enables better rupture risk and preventative treatment assessment. UIAs are usually diagnosed on…”
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