Search Results - "Timmins, Lucas H"

Impact of combined plaque structural stress and wall shear stress on coronary plaque progression, regression, and changes in composition by Costopoulos, Charis, Timmins, Lucas H, Huang, Yuan, Hung, Olivia Y, Molony, David S, Brown, Adam J, Davis, Emily L, Teng, Zhongzhao, Gillard, Jonathan H, Samady, Habib, Bennett, Martin R

“…Abstract Aims The focal distribution of atherosclerotic plaques suggests that local biomechanical factors may influence plaque development. Methods and results…”
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Combination of plaque burden, wall shear stress, and plaque phenotype has incremental value for prediction of coronary atherosclerotic plaque progression and vulnerability by Corban, Michel T, Eshtehardi, Parham, Suo, Jin, McDaniel, Michael C, Timmins, Lucas H, Rassoul-Arzrumly, Emad, Maynard, Charles, Mekonnen, Girum, King, Spencer, Quyyumi, Arshed A, Giddens, Don P, Samady, Habib

“…Abstract Aims Large plaque burden, certain phenotypes, and low wall shear stress (WSS) are associated with adverse outcomes and high WSS with development of…”
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Disturbed Flow Promotes Arterial Stiffening Through Thrombospondin-1 (TSP-1) by Kim, Chan Woo, Pokutta-Paskaleva, Anastassia, Kumar, Sandeep, Timmins, Lucas H, Morris, Andrew D, Kang, Dong-Won, Dalal, Sidd, Chadid, Tatiana, Kuo, Katie M, Raykin, Julia, Li, Haiyan, Yanagisawa, Hiromi, Gleason, Rudolph L, Jo, Hanjoong, Brewster, Luke P

“…BACKGROUND—Arterial stiffness and wall shear stress are powerful determinants of cardiovascular health, and arterial stiffness is associated with increased…”
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Increased artery wall stress post-stenting leads to greater intimal thickening by Timmins, Lucas H, Miller, Matthew W, Clubb, Fred J, Moore, James E

“…Since the first human procedure in the late 1980s, vascular stent implantation has been accepted as a standard form of treatment of atherosclerosis. Despite…”
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Structural inhomogeneity and fiber orientation in the inner arterial media by Timmins, Lucas H, Wu, Qiaofeng, Yeh, Alvin T, Moore, Jr, James E, Greenwald, Stephen E

“…The microstructural orientation of vascular wall constituents is of interest to scientists and clinicians because alterations in their native states are…”
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An endovascular model of ischemic myopathy from peripheral arterial disease by Long, Chandler A., MD, Timmins, Lucas H., PhD, Koutakis, Panagiotis, PhD, Goodchild, Traci T., PhD, Lefer, David J., PhD, Pipinos, Iraklis I., MD, Casale, George P., PhD, Brewster, Luke P., MD, PhD

“…Abstract Objective Peripheral arterial disease (PAD) is a significant age-related medical condition with limited pharmacologic options. Severe PAD, termed…”
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Biomechanics and inflammation in atherosclerotic plaque erosion and plaque rupture: implications for cardiovascular events in women by Campbell, Ian C, Suever, Jonathan D, Timmins, Lucas H, Veneziani, Alessandro, Vito, Raymond P, Virmani, Renu, Oshinski, John N, Taylor, W Robert

“…Although plaque erosion causes approximately 40% of all coronary thrombi and disproportionally affects women more than men, its mechanism is not well…”
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Comprehensive Assessment of Coronary Plaque Progression With Advanced Intravascular Imaging, Physiological Measures, and Wall Shear Stress: A Pilot Double‐Blinded Randomized Controlled Clinical Trial of Nebivolol Versus Atenolol in Nonobstructive Coronary Artery Disease by Hung, Olivia Y., Molony, David, Corban, Michel T., Rasoul‐Arzrumly, Emad, Maynard, Charles, Eshtehardi, Parham, Dhawan, Saurabh, Timmins, Lucas H., Piccinelli, Marina, Ahn, Sung Gyun, Gogas, Bill D., McDaniel, Michael C., Quyyumi, Arshed A., Giddens, Don P., Samady, Habib

“…Background We hypothesized that nebivolol, a β‐blocker with nitric oxide–mediated activity, compared with atenolol, a β‐blocker without such activity, would…”
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Effects of Stent Design and Atherosclerotic Plaque Composition on Arterial Wall Biomechanics by Timmins, Lucas H., Meyer, Clark A., Moreno, Michael R., Moore, James E.

“…Purpose: To examine the solid mechanical effects of varying stent design and atherosclerotic plaque stiffness on the biomechanical environment induced in a…”
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Coronary Artery Wall Shear Stress Is Associated With Progression and Transformation of Atherosclerotic Plaque and Arterial Remodeling in Patients With Coronary Artery Disease by SAMADY, Habib, ESHTEHARDI, Parham, MCDANIEL, Michael C, JIN SUO, DHAWAN, Saurabh S, MAYNARD, Charles, TIMMINS, Lucas H, QUYYUMI, Arshed A, GIDDENS, Don P

“…Experimental studies suggest that low wall shear stress (WSS) promotes plaque development and high WSS is associated with plaque destabilization. We…”
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Myocardial Bridging: Contemporary Understanding of Pathophysiology With Implications for Diagnostic and Therapeutic Strategies by CORBAN, Michel T, HUNG, Olivia Y, ESHTEHARDI, Parham, RASOUL-ARZRUMLY, Emad, MCDANIEL, Michael, MEKONNEN, Girum, TIMMINS, Lucas H, LUTZ, Jerre, GUYTON, Robert A, SAMADY, Habib

“…Patients with myocardial bridging are often asymptomatic, but this anomaly may be associated with exertional angina, acute coronary syndromes, cardiac…”
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Biomechanical Assessment of Fully Bioresorbable Devices by Gogas, Bill D., MD, King, Spencer B., MD, Timmins, Lucas H., PhD, Passerini, Tiziano, PhD, Piccinelli, Marina, PhD, Veneziani, Alessandro, PhD, Kim, Sungho, PhD, Molony, David S., PhD, Giddens, Don P., PhD, Serruys, Patrick W., MD, PhD, Samady, Habib, MD

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Integration of Febio as an Instructional Tool in the Undergraduate Biomechanics Curriculum by Jiang, David, Grainger, David W, Weiss, Jeffrey A, Timmins, Lucas H

“…Computer simulations play an important role in a range of biomedical engineering applications. Thus, it is important that biomedical engineering students…”
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Colocalization of Low and Oscillatory Coronary Wall Shear Stress With Subsequent Culprit Lesion Resulting in Myocardial Infarction in an Orthotopic Heart Transplant Patient by Timmins, Lucas H., PhD, Mackie, Benjamin D., MD, Oshinski, John N., PhD, Giddens, Don P., PhD, Samady, Habib, MD

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Myocardial Bridging by Corban, Michel T., MD, Hung, Olivia Y., MD, PhD, Eshtehardi, Parham, MD, Rasoul-Arzrumly, Emad, MD, McDaniel, Michael, MD, Mekonnen, Girum, MD, MPH, Timmins, Lucas H., PhD, Lutz, Jerre, MD, Guyton, Robert A., MD, Samady, Habib, MD

“…Patients with myocardial bridging are often asymptomatic, but this anomaly may be associated with exertional angina, acute coronary syndromes, cardiac…”
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A Nonparametric Approach for Estimating Three-Dimensional Fiber Orientation Distribution Functions (ODFs) in Fibrous Materials by Rauff, Adam, Timmins, Lucas H., Whitaker, Ross T., Weiss, Jeffrey A.

“…Many biological tissues contain an underlying fibrous microstructure that is optimized to suit a physiological function. The fiber architecture dictates…”
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Model-Directed Design of Tissue Engineering Scaffolds by Cosgriff-Hernandez, Elizabeth, Timmins, Lucas H.

“…Scaffold-based tissue engineering requires a resorbable scaffold that can restore function and guide regeneration. Recent advances in material fabrication have…”
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Flow-based method demonstrates improved accuracy for calculating wall shear stress in arterial flows from 4D flow MRI data by Hurd, Elliott R., Iffrig, Elizabeth, Jiang, David, Oshinski, John N., Timmins, Lucas H.

“…Four-dimensional flow magnetic resonance imaging (i.e., 4D flow MRI) has become a valuable tool for the in vivo assessment of blood flow within large vessels…”
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On the use of constrained reactive mixtures of solids to model finite deformation isothermal elastoplasticity and elastoplastic damage mechanics by Zimmerman, Brandon K., Jiang, David, Weiss, Jeffrey A., Timmins, Lucas H., Ateshian, Gerard A.

“…This study presents a framework for plasticity and elastoplastic damage mechanics by treating materials as reactive solids whose internal composition evolves…”
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Oscillatory wall shear stress is a dominant flow characteristic affecting lesion progression patterns and plaque vulnerability in patients with coronary artery disease by Timmins, Lucas H., Molony, David S., Eshtehardi, Parham, McDaniel, Michael C., Oshinski, John N., Giddens, Don P., Samady, Habib

“…Although experimental studies suggest that low and oscillatory wall shear stress (WSS) promotes plaque transformation to a more vulnerable phenotype, this…”
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