Search Results - "Timmes, Andrew"

Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays by Wilham, Jason M, Orrú, Christina D, Bessen, Richard A, Atarashi, Ryuichiro, Sano, Kazunori, Race, Brent, Meade-White, Kimberly D, Taubner, Lara M, Timmes, Andrew, Caughey, Byron

“…A major problem for the effective diagnosis and management of prion diseases is the lack of rapid high-throughput assays to measure low levels of prions. Such…”
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Recombinant prion protein refolded with lipid and RNA has the biochemical hallmarks of a prion but lacks in vivo infectivity by Timmes, Andrew G, Moore, Roger A, Fischer, Elizabeth R, Priola, Suzette A

“…During prion infection, the normal, protease-sensitive conformation of prion protein (PrP(C)) is converted via seeded polymerization to an abnormal, infectious…”
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Identification and removal of proteins that co-purify with infectious prion protein improves the analysis of its secondary structure by Moore, Roger A., Timmes, Andrew G., Wilmarth, Phillip A., Safronetz, David, Priola, Suzette A.

“…Prion diseases are neurodegenerative disorders associated with the accumulation of an abnormal isoform of the mammalian prion protein (PrP). Fourier transform…”
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Co-infection with the friend retrovirus and mouse scrapie does not alter prion disease pathogenesis in susceptible mice by Leblanc, Pascal, Hasenkrug, Kim, Ward, Anne, Myers, Lara, Messer, Ronald J, Alais, Sandrine, Timmes, Andrew, Priola, Suzette A, Priola, Sue

“…Prion diseases are fatal, transmissible neurodegenerative diseases of the central nervous system. An abnormally protease-resistant and insoluble form (PrP(Sc))…”
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Correction: Co-Infection with the Friend Retrovirus and Mouse Scrapie Does Not Alter Prion Disease Pathogenesis in Susceptible Mice by Leblanc, Pascal, Hasenkrug, Kim, Ward, Anne, Myers, Lara, Messer, Ronald J., Alais, Sandrine, Timmes, Andrew, Priola, Suzette A.

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Axotomy Upregulates the Anterograde Transport and Expression of Brain-Derived Neurotrophic Factor by Sensory Neurons by Tonra, James R, Curtis, Rory, Wong, Vivien, Cliffer, Kenneth D, Park, John S, Timmes, Andrew, Nguyen, Trang, Lindsay, Ronald M, Acheson, Ann, DiStefano, Peter S

“…In addition to the known retrograde transport of neurotrophins, it is now evident that endogenous brain-derived neurotrophic factor (BDNF) is transported in…”
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Comparative profiling of highly enriched 22L and Chandler mouse scrapie prion protein preparations by Moore, Roger A, Timmes, Andrew, Wilmarth, Phillip A, Priola, Suzette A

“…Transmissible spongiform encephalopathies (TSEs) or prion diseases are characterized by the accumulation of an aggregated isoform of the prion protein (PrP)…”
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Biochemical and physiological properties of the DNA binding domain of AraC protein by Timmes, Andrew, Rodgers, Michael, Schleif, Robert

“…Intact AraC protein is poorly soluble and difficult to purify, whereas its dimerization domain is the opposite. Unexpectedly, the DNA binding domain of AraC…”
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Rapid End-Point Quantitation of Prion Seeding Activity with Sensitivity Comparable to Bioassays: e1001217 by Wilham, Jason M, Orrú, Christina D, Bessen, Richard A, Atarashi, Ryuichiro, Sano, Kazunori, Race, Brent, Meade-White, Kimberly D, Taubner, Lara M, Timmes, Andrew, Caughey, Byron

“…A major problem for the effective diagnosis and management of prion diseases is the lack of rapid high-throughput assays to measure low levels of prions. Such…”
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Recombinant Prion Protein Refolded with Lipid and RNA Has the Biochemical Hallmarks of a Prion but Lacks In Vivo Infectivity. e71081 by Timmes, Andrew G, Moore, Roger A, Fischer, Elizabeth R, Priola, Suzette A

“…During prion infection, the normal, protease-sensitive conformation of prion protein (PrPC) is converted via seeded polymerization to an abnormal, infectious…”
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Comparative profiling of highly enriched 22L and Chandler mouse scrapie prion protein preparations by Moore, Roger A., Timmes, Andrew, Wilmarth, Phillip A., Priola, Suzette A.

“…This article was originally published in Proteomics 2010, 10, 2858–2869, DOI 10.1002/pmic.201000104…”
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Activity of monomeric DNA binding domain of AraC with and without an N -terminal activating arm by Timmes, Andrew George

“…The binding of one subunit of a dimeric protein to a DNA half-site increases the effective concentration of the other subunit near the DNA and can thus…”
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