Search Results - "Timmerman, Laura M."

Identification of a novel conserved signaling motif in CD200 receptor required for its inhibitory function by Timmerman, Laura M, de Graaf, J Fréderique, Satravelas, Nikolaos, Kesmir, Çan, Meyaard, Linde, van der Vlist, Michiel

“…The inhibitory signaling of CD200 receptor 1 (CD200R) has been attributed to its NPxY signaling motif. However, NPxY-motifs are present in multiple protein…”
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Experimental Data on PIRCHE and T-Cell Reactivity: HLA-DPB1-Derived Peptides Identified by PIRCHE-I Show Binding to HLA-A02:01 in vitro and T-Cell Activation in vivo by Peereboom, Emma T.M., Maranus, Anna E., Timmerman, Laura M., Geneugelijk, Kirsten, Spierings, Eric

“…Abstract Introduction: Human leukocyte antigen (HLA)-DPB1 mismatches during hematopoietic stem cell transplantation (HSCT) with an unrelated donor result in an…”
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In vitro T cell responses to PD-1 blockade are reduced by IFN-α but do not predict therapy response in melanoma patients by Timmerman, Laura M., Hensen, Lobke C. M., van Eijs, Mick J. M., Verheijden, Rik J., Suijkerbuijk, Karijn P. M., Meyaard, Linde, van der Vlist, Michiel

“…PD-1 blockade therapy has revolutionized melanoma treatment, but still not all patients benefit and pre-treatment identification of those patients is…”
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Signaling by the inhibitory receptor CD200R is rewired by type I interferon by van der Vlist, Michiel, Ramos, M Inês Pascoal, van den Hoogen, Lucas L, Hiddingh, Sanne, Timmerman, Laura M, de Hond, Titus A P, Kaan, Ellen D, van der Kroef, Maarten, Lebbink, Robert Jan, Peters, Florence M A, Khoury-Hanold, William, Fritsch-Stork, Ruth, Radstake, Timothy R D J, Meyaard, Linde

“…CD200 receptor 1 (CD200R) is an inhibitory immunoreceptor that suppresses Toll-like receptor (TLR)–induced cytokine production through the adaptor protein Dok2…”
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Direct P70S6K1 inhibition to replace dexamethasone in synergistic combination with MCL-1 inhibition in multiple myeloma by Spaan, Ingrid, Timmerman, Laura M., Kimman, Thomas, Slomp, Anne, Cuenca, Marta, van Nieuwenhuijzen, Niels, Moesbergen, Laura M., Minnema, Monique C., Raymakers, Reinier A., Peperzak, Victor

“…•Dexamethasone-mediated inhibition of the mammalian target of rapamycin complex 1–P70S6K axis underlies synergy with MCL-1 inhibitor S63845.•P70S6K1 inhibitor…”
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Use of the TightRope Bone–Tendon–Bone for Anterior Cruciate Ligament Reconstruction by Timmerman, Laura A., MD

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