Search Results - "Timmer, Mattie S.M."

Trehalose glycolipids—synthesis and biological activities by Khan, Ashna A., Stocker, Bridget L., Timmer, Mattie S.M.

“…A variety of trehalose glycolipids have been isolated from natural sources, and several of these glycolipids exhibit important biological properties. These…”
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Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors by Nagata, Masahiro, Toyonaga, Kenji, Ishikawa, Eri, Haji, Shojiro, Okahashi, Nobuyuki, Takahashi, Masatomo, Izumi, Yoshihiro, Imamura, Akihiro, Takato, Koichi, Ishida, Hideharu, Nagai, Shigenori, Illarionov, Petr, Stocker, Bridget L., Timmer, Mattie S.M., Smith, Dylan G.M., Williams, Spencer J., Bamba, Takeshi, Miyamoto, Tomofumi, Arita, Makoto, Appelmelk, Ben J., Yamasaki, Sho

“…Helicobacter pylori causes gastritis, which has been attributed to the development of H. pylori–specific T cells during infection. However, the mechanism…”
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Lipid length and iso-branching of trehalose diesters influences Mincle agonist activity by Khan, Ayesha, Kodar, Kristel, Timmer, Mattie S.M., Stocker, Bridget L.

“…We report on the efficient synthesis of linear trehalose diesters (TDEs) and iso-branched TDEs (maradolipids or iso-TDEs) and their ability to activate bone…”
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The synthesis and evaluation of quinolinequinones as anti-mycobacterial agents by Santoso, Kristiana T., Menorca, Ayana, Cheung, Chen-Yi, Cook, Gregory M., Stocker, Bridget L., Timmer, Mattie S.M.

“…[Display omitted] A library of thirty-two quinolinequinones (QQs) with various amine substituents at the 6- and 7-positions were synthesised efficiently and in…”
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On one leg: trehalose monoesters activate macrophages in a Mincle-dependant manner by Stocker, Bridget L, Khan, Ashna A, Chee, Stephanie H, Kamena, Faustin, Timmer, Mattie S M

“…The C22 and C26 trehalose monoesters, each containing a single acyl chain, were synthesised in good overall yields and found to activate macrophages in a…”
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The synthesis of the molecular chaperone 2,5-dideoxy-2,5-imino-d-altritol via diastereoselective reductive amination and carbamate annulation by Hunt-Painter, Alex A., Stocker, Bridget L., Timmer, Mattie S.M.

“…The iminosugar 2,5-dideoxy-2,5-imino-d-altritol (DIA, 2) is a powerful competitive inhibitor of α-galactosidase A and has shown much promise as a…”
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Synthesis and Investigation of Phthalazinones as Antitubercular Agents by Santoso, Kristiana T., Cheung, Chen‐Yi, Hards, Kiel, Cook, Gregory M., Stocker, Bridget L., Timmer, Mattie S. M.

“…A series of 2‐ and 7‐substituted phthalazinones was synthesised and their potential as anti‐tubercular drugs assessed via Mycobacterium tuberculosis (mc26230)…”
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Chemical Tools for Studying the Biological Function of Glycolipids by Stocker, Bridget L., Timmer, Mattie S. M.

“…Glycolipids play an important role in many biological processes and to this end, synthetic chemists have developed a variety of new techniques and “chemical…”
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The Mincle ligand trehalose dibehenate differentially modulates M1‐like and M2‐like macrophage phenotype and function via Syk signaling by Kodar, Kristel, Harper, Jacquie L., McConnell, Melanie J., Timmer, Mattie S. M., Stocker, Bridget L.

“…Introduction Macrophages play a significant role in the progression of diseases, such as cancer, making them a target for immune‐modulating agents. Trehalose…”
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The Uptake of Trehalose Glycolipids by Macrophages Is Independent of Mincle by Kodar, Kristel, Eising, Selma, Khan, Ashna A., Steiger, Stefanie, Harper, Jacquie L., Timmer, Mattie S. M., Stocker, Bridget L.

“…Trehalose glycolipids play an important role in the pathogenesis of Mycobacterium tuberculosis and are used as adjuvants for vaccines; however, much still…”
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An improved synthesis of dansylated α-galactosylceramide and its use as a fluorescent probe for the monitoring of glycolipid uptake by cells by Cheng, Janice M.H., Chee, Stephanie H., Knight, Deborah A., Acha-Orbea, Hans, Hermans, Ian F., Timmer, Mattie S.M., Stocker, Bridget L.

“…[Display omitted] ► An efficient and novel synthesis of a fluorescent α-GalCer probe was developed. ► Early incorporation of the dansyl fluorosphore greatly…”
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The ‘mirror-image’ postulate as a guide to the selection and evaluation of pyrrolidines as α-l-fucosidase inhibitors by Stocker, Bridget L., Jongkees, Seino A.K., Win-Mason, Anna L., Dangerfield, Emma M., Withers, Stephen G., Timmer, Mattie S.M.

“…[Display omitted] ► Fleet’s mirror image postulate used as a guide to predict glycosidase activity. ► Series of pyrrolidines tested as glycosidase inhibitors…”
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I2-mediated carbamate annulation: scope and application in the synthesis of azasugars by Stocker, Bridget L., Win-Mason, Anna L., Timmer, Mattie S.M.

“…The I2-mediated carbamate annulation provides an efficient and highly stereoselective route for the synthesis of a variety of pyrrolidines and piperidines,…”
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Synthesis of functionalized heterocycles via a tandem Staudinger/aza-Wittig/Ugi multicomponent reaction by Timmer, Mattie S.M., Risseeuw, Martijn D.P., Verdoes, Martijn, Filippov, Dmitri V., Plaisier, Jasper R., van der Marel, Gijsbert A., Overkleeft, Herman S., van Boom, Jacques H.

“…[Display omitted] By combining a Staudinger/aza-Wittig and an Ugi three-component reaction in a one-pot process (SAWU-3CR), a new and efficient multicomponent…”
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Synthesis of phosphorus mono- and bicycles by catalytic ring-closing metathesis by Timmer, Mattie S.M, Ovaa, Huib, Filippov, Dmitri V, van der Marel, Gijs A, van Boom, Jacques H

“…A versatile route of synthesis of phosphorus oxide and phosphorus borane templates starting from the bifunctional phosphorylating agent…”
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Chimeric NOD2 Mincle Agonists as Vaccine Adjuvants by Dangerfield, Emma M., Ishizuka, Shigenari, Kodar, Kristel, Yamasaki, Sho, Timmer, Mattie S. M., Stocker, Bridget L.

“…There is a need for improved vaccine adjuvants to augment vaccine efficacy. One way to address this is by targeting multiple immune cell pathogen recognition…”
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Wavelength Dependent Photoluminescence Efficiency Enhancement in PbS/CdS Quantum Dot Hybrid Systems via Novel Tetracene-Based Chromophore Ligands by Brett, Matthew W., Nass, Liselotte C., Gordon, Calum K., Browne, Lara D., Stocker, Bridget L., Price, Michael B., Timmer, Mattie S. M., Davis, Nathaniel J. L. K.

“…Photon multiplication has been proposed as a possible route to surpassing the theoretical detailed-balance limit for single-junction photovoltaic cells…”
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Synthesis of Branched Trehalose Glycolipids and Their Mincle Agonist Activity by Bird, Jessie H, Khan, Ashna A, Nishimura, Naoya, Yamasaki, Sho, Timmer, Mattie S. M, Stocker, Bridget L

“…The macrophage inducible C-type lectin (Mincle) is a pattern recognition receptor that recognizes trehalose dimycolate (TDM), and trehalose dibehenate (TDB)…”
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Amide-linked brartemicin glycolipids exhibit Mincle-mediated agonist activity in vitro by Dangerfield, Emma M., Lynch, Amy T., Kodar, Kristel, Stocker, Bridget L., Timmer, Mattie S.M.

“…Lipidated derivatives of the natural product brartemicin show much promise as vaccine adjuvants due to their ability to signal through the Macrophage Inducible…”
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Synthesis and glycosidase inhibition of 3,4,5-trihydroxypiperidines using a one-pot amination-cyclisation cascade reaction by Dangerfield, Emma M., Meijlink, Michael A., Hunt-Painter, Alex A., Nasseri, Seyed A., Withers, Stephen G., Stocker, Bridget L., Timmer, Mattie S.M.

“…Trihydroxypiperidines are a therapeutically valuable class of iminosugar. We applied a one-pot amination-cyclisation cascade reaction to synthesise…”
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