Search Results - "Timmer, J."

Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood by Raue, A., Kreutz, C., Maiwald, T., Bachmann, J., Schilling, M., Klingmüller, U., Timmer, J.

“…Motivation: Mathematical description of biological reaction networks by differential equations leads to large models whose parameters are calibrated in order…”
Get full text

Left bundle branch area pacing outcomes: the multicentre European MELOS study by Jastrzębski, Marek, Kiełbasa, Grzegorz, Cano, Oscar, Curila, Karol, Heckman, Luuk, De Pooter, Jan, Chovanec, Milan, Rademakers, Leonard, Huybrechts, Wim, Grieco, Domenico, Whinnett, Zachary I, Timmer, Stefan A J, Elvan, Arif, Stros, Petr, Moskal, Paweł, Burri, Haran, Zanon, Francesco, Vernooy, Kevin

“…Permanent transseptal left bundle branch area pacing (LBBAP) is a promising new pacing method for both bradyarrhythmia and heart failure indications. However,…”
Get full text

Caspase substrates by Timmer, J C, Salvesen, G S

“…The relatively common occurrence of sequences within proteins that match the consensus substrate specificity of caspases in intracellular proteins suggests a…”
Get full text

Data2Dynamics: a modeling environment tailored to parameter estimation in dynamical systems by Raue, A, Steiert, B, Schelker, M, Kreutz, C, Maiwald, T, Hass, H, Vanlier, J, Tönsing, C, Adlung, L, Engesser, R, Mader, W, Heinemann, T, Hasenauer, J, Schilling, M, Höfer, T, Klipp, E, Theis, F, Klingmüller, U, Schöberl, B, Timmer, J

“…Modeling of dynamical systems using ordinary differential equations is a popular approach in the field of systems biology. Two of the most critical steps in…”
Get full text

Electronic Influence of the 2,2′-Bipyridine-6,6′-dicarboxylate Ligand in Ru-Based Molecular Water Oxidation Catalysts by Timmer, Brian J. J, Kravchenko, Oleksandr, Zhang, Biaobiao, Liu, Tianqi, Sun, Licheng

“…Water provides an ideal source for the production of protons and electrons required for generation of renewable fuels. Among the most-prominent…”
Get full text

Data-based identifiability analysis of non-linear dynamical models by Hengl, S., Kreutz, C., Timmer, J., Maiwald, T.

“…Motivation: Mathematical modelling of biological systems is becoming a standard approach to investigate complex dynamic, non-linear interaction mechanisms in…”
Get full text

Preorganized Frustrated Lewis Pairs by Bertini, Federica, Lyaskovskyy, Volodymyr, Timmer, Brian J. J, de Kanter, Frans J. J, Lutz, Martin, Ehlers, Andreas W, Slootweg, J. Chris, Lammertsma, Koop

“…Geminal frustrated Lewis pairs (FLPs) are expected to exhibit increased reactivity when the donor and acceptor sites are perfectly aligned. This is shown for…”
Get full text

Identifiability and observability analysis for experimental design in nonlinear dynamical models by Raue, A, Becker, V, Klingmüller, U, Timmer, J

“…Dynamical models of cellular processes promise to yield new insights into the underlying systems and their biological interpretation. The processes are usually…”
Get more information

Water Oxidation Initiated by In Situ Dimerization of the Molecular Ru(pdc) Catalyst by Daniel, Quentin, Duan, Lele, Timmer, Brian J. J, Chen, Hong, Luo, Xiaodan, Ambre, Ram, Wang, Ying, Zhang, Biaobiao, Zhang, Peili, Wang, Lei, Li, Fusheng, Sun, Junliang, Ahlquist, Mårten, Sun, Licheng

“…The mononuclear ruthenium complex [Ru­(pdc)­L3] (H2pdc = 2,6-pyridinedicarboxylic acid, L = N-heterocycles such as 4-picoline) has previously shown promising…”
Get full text

Simple and Effective Integration of Green Chemistry and Sustainability Education into an Existing Organic Chemistry Course by Timmer, Brian J. J, Schaufelberger, Fredrik, Hammarberg, Daniel, Franzén, Johan, Ramström, Olof, Dinér, Peter

“…Green chemistry and sustainable development have become increasingly important topics for the education of future chemists. The cross-disciplinary nature of…”
Get full text

Differences in dietary intake during chemotherapy in breast cancer patients compared to women without cancer by de Vries, Y. C., van den Berg, M. M. G. A., de Vries, J. H. M., Boesveldt, S., de Kruif, J. Th. C. M., Buist, N., Haringhuizen, A., Los, M., Sommeijer, D. W., Timmer-Bonte, J. H. N., van Laarhoven, H. W. M., Visser, M., Kampman, E., Winkels, R. M.

“…Purpose Breast cancer patients receiving chemotherapy often experience symptoms such as nausea, vomiting and loss of appetite that potentially affect dietary…”
Get full text

Multi-resource emergency supply contracts with asymmetric information in the after-sales services by Rahimi-Ghahroodi, S., Al Hanbali, A., Zijm, W.H.M., Timmer, J.B.

“…In this paper, we investigate the contract design in a multi-resource service supply chain between a first line service provider and an emergency supplier…”
Get full text

MRSA Infections in HIV-Infected People Are Associated with Decreased MRSA-Specific Th1 Immunity by Utay, Netanya S, Roque, Annelys, Timmer, J Katherina, Morcock, David R, DeLeage, Claire, Somasunderam, Anoma, Weintrob, Amy C, Agan, Brian K, Estes, Jacob D, Crum-Cianflone, Nancy F, Douek, Daniel C

“…People with HIV infection are at increased risk for community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) skin and soft tissue infections…”
Get full text

Emergency supply contracts for a service provider with limited local resources by Rahimi-Ghahroodi, S., Al Hanbali, A., Zijm, W.H.M., Timmer, J.B.

“…•Smart and novel contract models in the upstream echelon of after-sales service networks.•Combination of coordinated contracting and integrated resource…”
Get full text

A Unified Approach to the Helioseismic Inversion Problem of the Solar Meridional Flow from Global Oscillations by Schad, A, Timmer, J, Roth, M

“…Measurements from tracers and local helioseismology indicate the existence of a meridional flow in the Sun with strength in the order of 15 m s--1 near the…”
Get full text

Comprehensive estimation of input signals and dynamics in biochemical reaction networks by Schelker, M, Raue, A, Timmer, J, Kreutz, C

“…Cellular information processing can be described mathematically using differential equations. Often, external stimulation of cells by compounds such as drugs…”
Get full text

Identification of Nucleocytoplasmic Cycling as a Remote Sensor in Cellular Signaling by Databased Modeling by Swameye, I., Müller, T. G., Timmer, J., Sandra, O., Klingmüller, U.

“…Considerable progress has been made in identifying the molecular composition of complex signaling networks controlling cell proliferation, differentiation, and…”
Get full text

Predictive mathematical models of cancer signalling pathways by Bachmann, J., Raue, A., Schilling, M., Becker, V., Timmer, J., Klingmüller, U.

“…  Bachmann J, Raue A, Schilling M, Becker V, Timmer J, Klingmüller U (German Cancer Research Center, Heidelberg; BIOSS Centre for Biological Signalling…”
Get full text

Addressing parameter identifiability by model-based experimentation by Raue, A, Kreutz, C, Maiwald, T, Klingmuller, U, Timmer, J

“…Mathematical description of biological processes such as gene regulatory networks or signalling pathways by dynamic models utilising ordinary differential…”
Get full text

Off‐Set Interactions of Ruthenium–bda Type Catalysts for Promoting Water‐Splitting Performance by Timmer, Brian J. J., Kravchenko, Oleksandr, Liu, Tianqi, Zhang, Biaobiao, Sun, Licheng

“…O−O bond formation with Ru(bda)L2‐type catalysts is well‐known to proceed through a bimolecular reaction pathway, limiting the potential application of these…”
Get full text