Search Results - "Timme, R."

The DNA-PK Inhibitor VX-984 Enhances the Radiosensitivity of Glioblastoma Cells Grown In Vitro and as Orthotopic Xenografts by Timme, Cindy R, Rath, Barbara H, O'Neill, John W, Camphausen, Kevin, Tofilon, Philip J

“…Radiotherapy is a primary treatment modality for glioblastomas (GBM). Because DNA-PKcs is a critical factor in the repair of radiation-induced double strand…”
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Zebrafish as a Model for Toxicological Perturbation of Yolk and Nutrition in the Early Embryo by Sant, Karilyn E., Timme-Laragy, Alicia R.

“…Purpose of Review Developmental toxicity assessments often focus on structural outcomes and overlook subtle metabolic differences which occur during the early…”
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The Zebrafish (Danio rerio) Embryo Model as a Tool to Assess Drinking Water Treatment Efficacy for Freshwater Impacted by Crude Oil Spill by Roy, Monika A., Mohan, Aarthi, Karasik, Yankel, Tobiason, John E., Reckhow, David A., Timme‐Laragy, Alicia R.

“…Traditional approaches toward evaluating oil spill mitigation effectiveness in drinking water supplies using analytical chemistry can overlook residual…”
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Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio) by Hahn, Mark E., Timme-Laragy, Alicia R., Karchner, Sibel I., Stegeman, John J.

“…Oxidative stress is an important mechanism of chemical toxicity, contributing to developmental toxicity and teratogenesis as well as to cardiovascular and…”
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Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo by Timme-Laragy, Alicia R, Goldstone, Jared V, Imhoff, Barry R, Stegeman, John J, Hahn, Mark E, Hansen, Jason M

“…Embryonic development involves dramatic changes in cell proliferation and differentiation that must be highly coordinated and tightly regulated. Cellular redox…”
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Relationships between type 2 diabetes, cell dysfunction, and redox signaling: A meta‐analysis of single‐cell gene expression of human pancreatic α‐ and β‐cells by Marques, Emily Sara, Formato, Emily, Liang, Wenle, Leonard, Emily, Timme‐Laragy, Alicia R.

“…Background Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by insulin resistance and failure of β‐cells to meet the metabolic demand for…”
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Occurrence, antimicrobial resistance and whole genome sequence analysis of Salmonella serovars from pig farms in Ilorin, North-central Nigeria by Raufu, I.A., Ahmed, O.A., Aremu, A., Ameh, J.A., Timme, R.E., Hendriksen, R.S., Ambali, A.G.

“…Salmonella enterica is a foodborne pathogen of global public health importance with developing countries mostly affected. Foodborne outbreaks are often…”
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The emerging contaminant 3,3′-dichlorobiphenyl (PCB-11) impedes Ahr activation and Cyp1a activity to modify embryotoxicity of Ahr ligands in the zebrafish embryo model (Danio rerio) by Roy, Monika A., Sant, Karilyn E., Venezia, Olivia L., Shipman, Alix B., McCormick, Stephen D., Saktrakulkla, Panithi, Hornbuckle, Keri C., Timme-Laragy, Alicia R.

“…3,3′-dichlorobiphenyl (PCB-11) is an emerging PCB congener widely detected in environmental samples and human serum, but its toxicity potential is poorly…”
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The transcriptional response to oxidative stress during vertebrate development: effects of tert-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin by Hahn, Mark E, McArthur, Andrew G, Karchner, Sibel I, Franks, Diana G, Jenny, Matthew J, Timme-Laragy, Alicia R, Stegeman, John J, Woodin, Bruce R, Cipriano, Michael J, Linney, Elwood

“…Oxidative stress is an important mechanism of chemical toxicity, contributing to teratogenesis and to cardiovascular and neurodegenerative diseases. Developing…”
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Regulation of Ahr signaling by Nrf2 during development: Effects of Nrf2a deficiency on PCB126 embryotoxicity in zebrafish (Danio rerio) by Rousseau, Michelle E., Sant, Karilyn E., Borden, Linnea R., Franks, Diana G., Hahn, Mark E., Timme-Laragy, Alicia R.

“…•Zebrafish mutants nrf2afh318/fh318 are more sensitive to PCB126 embryotoxicity.•Induction of cyp1a expression with PCB126 exposure was higher in nrf2a…”
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Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio by Williams, Larissa M, Timme-Laragy, Alicia R, Goldstone, Jared V, McArthur, Andrew G, Stegeman, John J, Smolowitz, Roxanna M, Hahn, Mark E

“…Transcription factors in the CNC-bZIP family (NFE2, NRF1, NRF2 and NRF3) regulate genes with a wide range of functions in response to both physiological and…”
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Nrf2b, Novel Zebrafish Paralog of Oxidant-responsive Transcription Factor NF-E2-related Factor 2 (NRF2) by Timme-Laragy, Alicia R., Karchner, Sibel I., Franks, Diana G., Jenny, Matthew J., Harbeitner, Rachel C., Goldstone, Jared V., McArthur, Andrew G., Hahn, Mark E.

“…NF-E2-related factor 2 (NRF2; also called NFE2L2) and related NRF family members regulate antioxidant defenses by activating gene expression via antioxidant…”
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The Role of the Aryl Hydrocarbon Receptor Pathway in Mediating Synergistic Developmental Toxicity of Polycyclic Aromatic Hydrocarbons to Zebrafish by Billiard, Sonya M., Timme-Laragy, Alicia R., Wassenberg, Deena M., Cockman, Crystal, Di Giulio, Richard T.

“…Planar halogenated aromatic hydrocarbons (pHAHs), such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), show strong binding affinity for the aryl hydrocarbon…”
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Mapping glutathione utilization in the developing zebrafish (Danio rerio) embryo by Rastogi, Archit, Clark, Christopher W, Conlin, Sarah M, Brown, Sarah E, Timme-Laragy, Alicia R

“…Glutathione (GSH), the most abundant vertebrate endogenous redox buffer, plays key roles in organogenesis and embryonic development, however, organ-specific…”
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Synergistic induction of AHR regulated genes in developmental toxicity from co-exposure to two model PAHs in zebrafish by Timme-Laragy, Alicia R., Cockman, Crystal J., Matson, Cole W., Di Giulio, Richard T.

“…Polycyclic aromatic hydrocarbons (PAHs) are pollutants created by the incomplete combustion of carbon, and are increasing in the environment largely due to the…”
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Modulating glutathione thiol status alters pancreatic β-cell morphogenesis in the developing zebrafish (Danio rerio) embryo by Rastogi, Archit, Severance, Emily G., Jacobs, Haydee M., Conlin, Sarah M., Islam, Sadia T., Timme-Laragy, Alicia R.

“…Emerging evidence suggests that redox-active chemicals perturb pancreatic islet development. To better understand potential mechanisms for this, we used…”
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Activation of Nrf2 at Critical Windows of Development Alters Tissue-Specific Protein S -Glutathionylation in the Zebrafish ( Danio rerio ) Embryo by Marques, Emily S, Severance, Emily G, Arsenault, Paige, Zahn, Sarah M, Timme-Laragy, Alicia R

“…Activation of Nrf2-the master regulator of antioxidative response-at different stages of embryonic development has been shown to result in changes in gene…”
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Ahr2-dependence of PCB126 effects on the swim bladder in relation to expression of CYP1 and cox-2 genes in developing zebrafish by Jönsson, Maria E., Kubota, Akira, Timme-Laragy, Alicia R., Woodin, Bruce, Stegeman, John J.

“…The teleost swim bladder is assumed a homolog of the tetrapod lung. Both swim bladder and lung are developmental targets of persistent aryl hydrocarbon…”
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Gene knockdown by morpholino-modified oligonucleotides in the zebrafish (Danio rerio) model: applications for developmental toxicology by Timme-Laragy, Alicia R, Karchner, Sibel I, Hahn, Mark E

“…The zebrafish (Danio rerio) has long been used as a model for developmental biology, making it an excellent model to use also in developmental toxicology. The…”
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Corrigendum to “Mapping glutathione utilization in the developing zebrafish (Danio rerio) embryo” [Redox Biol. 26 (2019) 101235] by Rastogi, Archit, Clark, Christopher W., Conlin, Sarah M., Brown, Sarah E., Timme-Laragy, Alicia R.

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