Search Results - "Timm, David D"

Quantifying dynamic range in red blood cell energetics: Evidence of progressive energy failure during storage by Rogers, Stephen C., Ge, Xia, Brummet, Mary, Lin, Xue, Timm, David D., d'Avignon, Andre, Garbow, Joel R., Kao, Jeff, Prakash, Jaya, Issaian, Aaron, Eisenmesser, Elan Z., Reisz, Julie A., D'Alessandro, Angelo, Doctor, Allan

“…Background During storage, red blood cells (RBCs) undergo significant biochemical and morphologic changes, referred to collectively as the “storage lesion”. It…”
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Effect of plasma processing and storage on microparticle abundance, nitric oxide scavenging, and vasoactivity by Rogers, Stephen C., Moynihan, Francis T., McDonough, Ryan, Timm, David D., Hovmand‐Warner, Eyvind, Frazier, Elfaridah, Thomas, Kimberly A., Spinella, Philip C., Doctor, Allan

“…BACKGROUND We set out to define the impact of collection, processing, and storage on plasma product microparticle (MP) abundance, potential for nitric oxide…”
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Thiazole-substituted benzenesulfonamides as inhibitors of 12 human carbonic anhydrases by Čapkauskaitė, Edita, Zubrienė, Asta, Paketurytė, Vaida, Timm, David D., Tumkevičius, Sigitas, Matulis, Daumantas

“…[Display omitted] •Sulfonamides with thiazolyl moiety were designed and evaluated as inhibitors of 12 human CAs.•The para compounds 1a–c bound stronger than…”
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Functionalization of Fluorinated Benzenesulfonamides and Their Inhibitory Properties toward Carbonic Anhydrases by Dudutienė, Virginija, Zubrienė, Asta, Smirnov, Alexey, Timm, David D., Smirnovienė, Joana, Kazokaitė, Justina, Michailovienė, Vilma, Zakšauskas, Audrius, Manakova, Elena, Gražulis, Saulius, Matulis, Daumantas

“…Substituted tri‐ and tetrafluorobenzenesulfonamides were designed, synthesized, and evaluated as high‐affinity and isoform‐selective carbonic anhydrase (CA)…”
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Intrinsic Thermodynamics and Structures of 2,4‐ and 3,4‐Substituted Fluorinated Benzenesulfonamides Binding to Carbonic Anhydrases by Zubrienė, Asta, Smirnov, Alexey, Dudutienė, Virginija, Timm, David D., Matulienė, Jurgita, Michailovienė, Vilma, Zakšauskas, Audrius, Manakova, Elena, Gražulis, Saulius, Matulis, Daumantas

“…The goal of rational drug design is to understand structure–thermodynamics correlations in order to predict the chemical structure of a drug that would exhibit…”
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Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV by Mickevičiūtė, Aurelija, Timm, David D., Gedgaudas, Marius, Linkuvienė, Vaida, Chen, Zhiwei, Waheed, Abdul, Michailovienė, Vilma, Zubrienė, Asta, Smirnov, Alexey, Čapkauskaitė, Edita, Baranauskienė, Lina, Jachno, Jelena, Revuckienė, Jurgita, Manakova, Elena, Gražulis, Saulius, Matulienė, Jurgita, Di Cera, Enrico, Sly, William S., Matulis, Daumantas

“…Membrane-associated carbonic anhydrase (CA) isoform IV participates in carbon metabolism and pH homeostasis and is implicated in the development of eye…”
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Discovery and Characterization of Novel Selective Inhibitors of Carbonic Anhydrase IX by Dudutienė, Virginija, Matulienė, Jurgita, Smirnov, Alexey, Timm, David D, Zubrienė, Asta, Baranauskienė, Lina, Morku̅naitė, Vaida, Smirnovienė, Joana, Michailovienė, Vilma, Juozapaitienė, Vaida, Mickevičiu̅tė, Aurelija, Kazokaitė, Justina, Bakšytė, Sandra, Kasiliauskaitė, Aistė, Jachno, Jelena, Revuckienė, Jurgita, Kišonaitė, Miglė, Pilipuitytė, Vilma, Ivanauskaitė, Eglė, Milinavičiu̅tė, Goda, Smirnovas, Vytautas, Petrikaitė, Vilma, Kairys, Visvaldas, Petrauskas, Vytautas, Norvaišas, Povilas, Lingė, Darius, Gibieža, Paulius, Čapkauskaitė, Edita, Zakšauskas, Audrius, Kazlauskas, Egidijus, Manakova, Elena, Gražulis, Saulius, Ladbury, John E, Matulis, Daumantas

“…Human carbonic anhydrase IX (CA IX) is highly expressed in tumor tissues, and its selective inhibition provides a potential target for the treatment of…”
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Intrinsic Thermodynamics - Structure Correlation of Carbonic Anhydrase Inhibitors by Matulis, Daumantas, Zubrienė, Asta, Baranauskienė, Lina, Smirnov, Alexey, Morkūnaitė, Vaida, Smirnovienė, Joana, Kišonaitė, Miglė, Norvaišas, Povilas, Timm, David D.

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Combinatorial Design of Isoform‐Selective N‐Alkylated Benzimidazole‐Based Inhibitors of Carbonic Anhydrases by Čapkauskaitė, Edita, Linkuvienė, Vaida, Smirnov, Alexey, Milinavičiūtė, Goda, Timm, David D., Kasiliauskaitė, Aistė, Manakova, Elena, Gražulis, Saulius, Matulis, Daumantas

“…Human carbonic anhydrases comprise a family of isoforms that form structurally similar active site and thus it is difficult to design inhibitors that would…”
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