Search Results - "Timchenko, L T"

Disruption of Splicing Regulated by a CUG-Binding Protein in Myotonic Dystrophy by Philips, Anne V., Timchenko, Lubov T., Cooper, Thomas A.

“…Myotonic dystrophy (DM) is caused by a CTG expansion in the 3′ untranslated region of the DM gene. One model of DM pathogenesis suggests that RNAs from the…”
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Molecular Basis for Impaired Muscle Differentiation in Myotonic Dystrophy by Timchenko, Nikolai A., Iakova, Polina, Cai, Zong-Jin, Smith, James R., Timchenko, Lubov T.

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Novel Proteins with Binding Specificity for DNA CTG Repeats And RNA Cug Repeats: Implications for Myotonic Dystrophy by Timchenko, L. T., Timchenko, N. A., Caskey, C. T., Roberts, R.

“…While an unstable CTG triplet repeat expansion is responsible for myotonic dystrophy, the mechanism whereby this genetic defect induces the disease remains…”
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Triplet repeat disorders: discussion of molecular mechanisms by Timchenko, L. T, Caskey, C. T

“…Comparison of the growing number of disorders known to be associated with triplet repeat expansions reveals both common features and a diversity of molecular…”
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Cardiac Elav-type RNA-binding Protein (ETR-3) Binds to RNA CUG Repeats Expanded in Myotonic Dystrophy by Lu, Xiaohui, Timchenko, Nikolai A., Timchenko, Lubov T.

“…Myotonic dystrophy (DM) is a neuromuscular disorder associated with CTG triplet repeat expansion in the myotonin protein kinase gene (DMPK). We previously…”
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Myotonic Dystrophy: The Role of RNA CUG Triplet Repeats by Timchenko, Lubov T.

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Trinucleotide repeat disorders in humans: discussions of mechanisms and medical issues by Timchenko, L T, Caskey, C T

“…Several human disorders are now known to be caused by expansion of unstable trinucleotide repeat sequences, including fragile X syndrome (FRAX), myotonic…”
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RNA CUG Repeats Sequester CUGBP1 and Alter Protein Levels and Activity of CUGBP1 by Timchenko, Nikolai A., Cai, Zong-Jin, Welm, Alana L., Reddy, Sita, Ashizawa, Tetsuo, Timchenko, Lubov T.

“…An RNA CUG triplet repeat binding protein, CUGBP1, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the 3′-untranslated…”
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CUG repeat binding protein (CUGBP1) interacts with the 5′ region of C/EBPβ mRNA and regulates translation of C/EBPβ isoforms by Timchenko, Nikolai A., Lu, Alana L., Timchenko, Lubov T.

“…The transcription factor CCAAT/enhancer binding protein β, C/EBPβ, plays a significant role in the regulation of hepatocyte growth and differentiation. A…”
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Myotonic dystrophy: discussion of molecular mechanism by Caskey, C T, Swanson, M S, Timchenko, L T

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Identification of a (CUG)n Triplet Repeat RNA-Binding Protein and Its Expression in Myotonic Dystrophy by Timchenko, Lubov T., Miller, Jill W., Timchenko, Nikolaj A., DeVore, Druery R., Datar, Kshama V., Lin, Lijun, Roberts, Robert, Caskey, C. Thomas, Swanson, Maurice S.

“…Myotonic dystrophy (DM) is an autosomal dominant neuromuscular disease that is associated with a (CTG)n repeat expansion in the 3′-untranslated region of the…”
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Translational induction of liver-enriched transcriptional inhibitory protein during acute phase response leads to repression of CCAAT/enhancer binding protein alpha mRNA by Welm, A L, Mackey, S L, Timchenko, L T, Darlington, G J, Timchenko, N A

“…Lipopolysacharide (LPS) induced acute phase response (APR) in mouse liver leads to elevation of the low molecular weight CCAAT/Enhancer binding protein (C/EBP)…”
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Preproceruloplasmin is a primary product of cell-free translation of ceruloplasmin messenger RNA by Puchkova, L V, Gaitskhoki, V S, Monakhov, N K, Timchenko, L T, Neifakh, S A

“…Biosynthesis of ceruloplasmin was studied in wheat germ extract programmed with polysomal RNA from rat liver. Optimal potassium concentration for the total…”
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Altered Phosphorylation and Intracellular Distribution of a (CUG)n Triplet Repeat RNA-Binding Protein in Patients with Myotonic Dystrophy and in Myotonin Protein Kinase Knockout Mice by Roberts, Robert, Timchenko, Nikolaj A., Miller, Jill W., Reddy, Sita, Caskey, C. Thomas, Swanson, Maurice S., Timchenko, Lubov T.

“…Myotonic dystrophy (DM) is associated with expansion of CTG repeats in the 3′-untranslated region of the myotonin protein kinase (DMPK) gene. The molecular…”
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Myotonic dystrophy : The role of RNA CUG triplet repeats : Trinucleotide repeats by TIMCHENKO, L. T

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Overexpression of CUG Triplet Repeat-binding Protein, CUGBP1, in Mice Inhibits Myogenesis by Timchenko, Nikolai A., Patel, Roma, Iakova, Polina, Cai, Zong-Jin, Quan, Ling, Timchenko, Lubov T.

“…Accumulation of RNA CUG repeats in myotonic dystrophy type 1 (DM1) patients leads to the induction of a CUG-binding protein, CUGBP1, which increases…”
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RNA CUG-binding Protein 1 Increases Translation of 20-kDa Isoform of CCAAT/Enhancer-binding Protein β by Interacting with the α and β Subunits of Eukaryotic Initiation Translation Factor 2 by Timchenko, Nikolai A., Wang, Gou-Li, Timchenko, Lubov T.

“…Expression of a dominant negative 20-kDa isoform of CCAAT/enhancer-binding protein (C/EBPβ), LIP, is increased in proliferating livers and in tumor cells. Two…”
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Rat DNA sequence associated with a complex form of DNA polymerase alpha in nonregenerating liver interacts with a ubiquitous transcription/replication factor Oct-1 by Timchenko, N A, Zhuchenko, O P, Timchenko, L T, Iguchi-Ariga, S M, Ariga, H, Bozhkov, V M, Tomilin, N V

“…A ubiquitous mammalian transcription factor, Oct-1 (also known as OTF-1, NF-A1, OBP100, or NFIII), stimulates the initiation of replication of adenovirus DNA,…”
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Calreticulin Interacts with C/EBP[alpha] and C/EBP beta mRNAs and Represses Translation of C/EBP Proteins by Timchenko, L T, Iakova, P, Welm, AL, Cai, Z J, Timchenko, NA

“…We previously identified an RNA binding protein, CUGBP1, which binds to GCN repeats located within the 5' region of C/EBP beta mRNAs and regulates translation…”
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Calreticulin Interacts with C/EBPα and C/EBPβ mRNAs and Represses Translation of C/EBP Proteins by Timchenko, Lubov T., Iakova, Polina, Welm, Alana L., Cai, Z.-J., Timchenko, Nikolai A.

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