Search Results - "Timblin, C."

Implementation fidelity of the Falls Management Exercise Programme: a mixed methods analysis using a conceptual framework for implementation fidelity by Orton, E., Lafond, N., Skelton, D.A., Coupland, C., Gladman, J.R.F., Iliffe, S., Logan, P.A., Masud, T., Timblin, C., Timmons, S., Kendrick, D.

“…Falls in older adults cause significant morbidity and mortality and incur cost to health and care services. The Falls Management Exercise (FaME) programme is a…”
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Evaluating the effect of child home safety training upon three family support practitioner groups: a mixed-methods study by Taylor, MJ, Patel, T, Orton, E, Watson, MC, Hayes, M, Clarke, R, Stewart, S, Timblin, C, Kendrick, D

“…Aims: Unintentional injuries in the home contribute substantially to preschool child morbidity and mortality. Practitioners such as health visitors, family…”
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The short-term cost of falls, poisonings and scalds occurring at home in children under 5 years old in England: multicentre longitudinal study by Cooper, N J, Kendrick, D, Timblin, C, Hayes, M, Majsak-Newman, G, Meteyard, K, Hawkins, A, Kay, B

“…Childhood falls, poisonings and scalds, occurring predominantly in the home, are an important public health problem, yet there is limited evidence on the costs…”
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Mesothelial cell transformation requires increased AP-1 binding activity and ERK-dependent Fra-1 expression by RAMOS-NINO, Maria E, TIMBLIN, Cynthia R, MOSSMAN, Brooke T

“…Mesothelioma is a unique and insidious tumor associated historically with occupational exposure to asbestos. The transcription factor, activator protein-1…”
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Transcriptional activation of the proto-oncogene c-jun by asbestos and H2O2 is directly related to increased proliferation and transformation of tracheal epithelial cells by TIMBLIN, C. R, JANSSEN, Y. W. M, MOSSMAN, B. T

“…Asbestos causes persistent increases in c-jun mRNA and AP-1 DNA binding activity in hamster tracheal epithelial (HTE) cells, the progenitor cell type of…”
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Silica-induced activation of c-Jun-NH2-Terminal amino kinases, protracted expression of the activator protein-1 proto-oncogene, fra-1, and S-phase alterations are mediated via oxidative stress by SHUKLA, Arti, TIMBLIN, Cynthia R, HUBBARD, Andrea K, BRAVMAN, Jonathan, MOSSMAN, Brooke T

“…Crystalline silica has been classified as a group 1 human carcinogen in the lung. However, its mechanisms of action on pulmonary epithelial cells which give…”
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Cell Signaling Pathways Elicited by Asbestos by Mossman, Brooke T., Faux, Steven, Janssen, Yvonne, Jimenez, Luis A., Timblin, Cynthia, Zanella, Christine, Goldberg, Jonathan, Walsh, Eric, Barchowsky, Aaron, Driscoll, Kevin

“…In recent years, it has become apparent that minerals can trigger alterations in gene expression by initiating signaling events upstream of gene…”
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A mutant epidermal growth factor receptor targeted to lung epithelium inhibits asbestos-induced proliferation and proto-oncogene expression by MANNING, Christopher B, CUMMINS, Andrew B, JUNG, Michael W, BERLANGER, Ingrid, TIMBLIN, Cynthia R, PALMER, Cathy, TAATJES, Douglas J, HEMENWAY, David, VACEK, Pamela, MOSSMAN, Brooke T

“…Asbestos is a ubiquitous naturally occurring fiber causing multiple cancers and fibroproliferativedisease. The mechanisms of epithelial cell hyperplasia, a…”
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Patterns of c-fos and c-jun proto-oncogene expression, apoptosis, and proliferation in rat pleural mesothelial cells exposed to erionite or asbestos fibers by TIMBLIN, C. R, GUTHRIE, G. D, JANSSEN, Y. W. M, WALSH, E. S, VACEK, P, MOSSMAN, B. T

“…Erionite, a naturally occurring fibrous zeolite, is associated with the development of nonmalignant and malignant lung diseases and is more carcinogenic than…”
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Asbestos-induced phosphorylation of epidermal growth factor receptor is linked to c-fos and apoptosis by Zanella, C L, Timblin, C R, Cummins, A, Jung, M, Goldberg, J, Raabe, R, Tritton, T R, Mossman, B T

“…We examined the mechanisms of interaction of crocidolite asbestos fibers with the epidermal growth factor (EGF) receptor (EGFR) and the role of the…”
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Role of Mitogen-Activated Protein Kinases, Early Response Protooncogenes, and Activator Protein-1 in Cell Signaling by Asbestos by Mossman, Brooke, Hubbard, Andrea, Shukla, Arti, Timblin, Cynthia R.

“…Cell signaling by pathogenic minerals may initiate the transactivation of genes that are critical to carcinogenesis and fibroproliferative diseases of the lung…”
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Application for PCR technology to subtractive cDNA cloning : identification of genes expressed specifically in murine plasmacytoma cells by TIMBLIN, C, BATTEY, J, KUEHL, W. M

“…We describe a simple method for preparing a renewable source of subtractive cDNA which can be used as a hybridization probe or as insert which can be cloned…”
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Ultrafine Airborne Particles Cause Increases in Protooncogene Expression and Proliferation in Alveolar Epithelial Cells by Timblin, Cynthia R., Shukla, Arti, Berlanger, Ingrid, BeruBe, Kelly A., Churg, Andrew, Mossman, Brooke T.

“…Exposure to ambient particulate matter (PM) is linked to increases in respiratory morbidity and exacerbation of cardiopulmonary diseases. However, the…”
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A murine cDNA encodes a pan-epithelial glycoprotein that is also expressed on plasma cells by Bergsagel, PL, Victor-Kobrin, C, Timblin, CR, Trepel, J, Kuehl, WM

“…Using a subtractive cDNA approach, we have identified a number of genes expressed in murine plasmacytomas, but not B or pre-B lymphomas. One of these genes,…”
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Inhibition of protein kinase C prevents asbestos-induced c-fos and c-jun proto-oncogene expression in mesothelial cells by FUNG, H, QUINLAN, T. R, JANSSEN, Y. M. W, TIMBLIN, C. R, MARSH, J. P, HEINTZ, N. H, TAATJES, D. J, VACEK, P, JAKEN, S, MOSSMAN, B. T

“…Asbestos and the phorbol ester tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), increase c-fos and c-jun mRNA levels and AP-1 DNA binding activity…”
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GRP78, HSP72/73, and cJun stress protein levels in lung epithelial cells exposed to asbestos, cadmium, or H2O2 by Timblin, C R, Janssen, Y M, Goldberg, J L, Mossman, B T

“…Occupational exposure to crocidolite asbestos is associated with the development of nonmalignant and malignant pulmonary disease. Considerable evidence…”
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Modulation of cell injury and survival by high glucose and advancing age by Fukagawa, Naomi K, Li, Muyao, Timblin, Cynthia R, Mossman, Brooke T

“…Old age is associated with a higher prevalence of cardiovascular disease and diabetes mellitus. Vascular smooth muscle cells (VSMC) play a role in the…”
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Mechanisms of Asbestos-induced Nitric Oxide Production by Rat Alveolar Macrophages in Inhalation and in vitro Models by Quinlan, Timothy R, BeruBe, Kelly A, Hacker, Miles P, Taatjes, Douglas J, Timblin, Cynthia R, Goldberg, Jonathan, Kimberley, Priscilla, O’Shaughnessy, Patrick, Hemenway, David, Torino, Jennifer, Jimenez, Luis A, Mossman, Brooke T

“…To evaluate the contribution of reactive nitrogen species to inflammation by asbestos, Fischer 344 rats were exposed to crocidolite or chrysotile asbestos by…”
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Novel cell imaging techniques show induction of apoptosis and proliferation in mesothelial cells by asbestos by Goldberg, JL, Zanella, CL, Janssen, YM, Timblin, CR, Jimenez, LA, Vacek, P, Taatjes, DJ, Mossman, BT

“…We developed in situ dual-fluorescence detection techniques for measuring apoptosis and proliferation simultaneously in single dishes of cells. The…”
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Use of transgenic luciferase reporter mice to determine activation of transcription factors and gene expression by fibrogenic particles by Hubbard, A K, Timblin, C R, Rincon, M, Mossman, B T

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