Search Results - "Timashev, Leonid A."

Characterization of t-loop formation by TRF2 by Timashev, Leonid A., De Lange, Titia

“…T-loops are thought to hide telomeres from DNA damage signaling and DSB repair pathways. T-loop formation requires the shelterin component TRF2, which…”
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Sae2 promotes DNA damage resistance by removing the Mre11–Rad50–Xrs2 complex from DNA and attenuating Rad53 signaling by Chen, Huan, Donnianni, Roberto A., Handa, Naofumi, Deng, Sarah K., Oh, Julyun, Timashev, Leonid A., Kowalczykowski, Stephen C., Symington, Lorraine S.

“…Significance Chromosomal double-strand breaks (DSBs) are cytotoxic forms of DNA damage that must be accurately repaired to maintain genome integrity. The…”
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The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction by Timashev, Leonid A, Babcock, Hazen, Zhuang, Xiaowei, de Lange, Titia

“…Telomeres are protected by shelterin, a six-subunit protein complex that represses the DNA damage response (DDR) at chromosome ends. Extensive data suggest…”
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Template switching during break-induced replication is promoted by the Mph1 helicase in Saccharomyces cerevisiae by Stafa, Anamarija, Donnianni, Roberto A, Timashev, Leonid A, Lam, Alicia F, Symington, Lorraine S

“…Chromosomal double-strand breaks (DSBs) that have only one end with homology to a donor duplex undergo repair by strand invasion followed by replication to the…”
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