Search Results - "Tilton, John C."

Entry inhibitors in the treatment of HIV-1 infection by Tilton, John C., Doms, Robert W.

“…Infection of target cells by HIV is a complex, multi-stage process involving attachment to host cells and CD4 binding, coreceptor binding, and membrane fusion…”
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Analysis of Individual Viral Particles by Flow Virometry by Tabler, Caroline O, Tilton, John C

“…This review focuses on the emerging field of flow virometry, the study and characterization of individual viral particles using flow cytometry instruments and…”
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Premature Activation of the HIV-1 Protease Is Influenced by Polymorphisms in the Hinge Region by Tabler, Caroline O, Wegman, Sarah J, Alhusaini, Najwa, Lee, Nicole F, Tilton, John C

“…HIV-1 protease inhibitors are an essential component of antiretroviral therapy. However, drug resistance is a pervasive issue motivating a persistent search…”
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Extracellular vesicles carry SARS‐CoV‐2 spike protein and serve as decoys for neutralizing antibodies by Troyer, Zach, Alhusaini, Najwa, Tabler, Caroline O., Sweet, Thomas, Carvalho, Karina Inacio Ladislau, Schlatzer, Daniela M., Carias, Lenore, King, Christopher L., Matreyek, Kenneth, Tilton, John C.

“…In late 2019, a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) emerged in Wuhan, China. SARS‐CoV‐2 and the disease it…”
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Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7 by Parrish, Nicholas F, Wilen, Craig B, Banks, Lauren B, Iyer, Shilpa S, Pfaff, Jennifer M, Salazar-Gonzalez, Jesus F, Salazar, Maria G, Decker, Julie M, Parrish, Erica H, Berg, Anna, Hopper, Jennifer, Hora, Bhavna, Kumar, Amit, Mahlokozera, Tatenda, Yuan, Sally, Coleman, Charl, Vermeulen, Marion, Ding, Haitao, Ochsenbauer, Christina, Tilton, John C, Permar, Sallie R, Kappes, John C, Betts, Michael R, Busch, Michael P, Gao, Feng, Montefiori, David, Haynes, Barton F, Shaw, George M, Hahn, Beatrice H, Doms, Robert W

“…Sexual transmission of human immunodeficiency virus type 1 (HIV-1) most often results from productive infection by a single transmitted/founder (T/F) virus,…”
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Phenotypic and Immunologic Comparison of Clade B Transmitted/Founder and Chronic HIV-1 Envelope Glycoproteins by WILEN, Craig B, PARRISH, Nicholas F, MONTEFIORI, David C, TILTON, John C, SHAW, George M, HAHN, Beatrice H, DOMS, Robert W, PFAFF, Jennifer M, DECKER, Julie M, HENNING, Elizabeth A, HAM, Hillel, PETERSEN, Josiah E, WOJCECHOWSKYJ, Jason A, SODROSKI, Joseph, HAYNES, Barton F

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A Maraviroc-Resistant HIV-1 with Narrow Cross-Resistance to Other CCR5 Antagonists Depends on both N-Terminal and Extracellular Loop Domains of Drug-Bound CCR5 by TILTON, John C, WILEN, Craig B, DOMS, Robert W, DIDIGU, Chukwuka A, SINHA, Rohini, HARRISON, Jessamina E, AGRAWAL-GAMSE, Caroline, HENNING, Elizabeth A, BUSHMAN, Frederick D, MARTIN, Jeffrey N, DEEKS, Steven G

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Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases by Wilen, Craig B, Wang, Jianbin, Tilton, John C, Miller, Jeffrey C, Kim, Kenneth A, Rebar, Edward J, Sherrill-Mix, Scott A, Patro, Sean C, Secreto, Anthony J, Jordan, Andrea P O, Lee, Gary, Kahn, Joshua, Aye, Pyone P, Bunnell, Bruce A, Lackner, Andrew A, Hoxie, James A, Danet-Desnoyers, Gwenn A, Bushman, Frederic D, Riley, James L, Gregory, Philip D, June, Carl H, Holmes, Michael C, Doms, Robert W

“…HIV-1 entry requires the cell surface expression of CD4 and either the CCR5 or CXCR4 coreceptors on host cells. Individuals homozygous for the ccr5Δ32…”
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Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244) by Eissmann, Philipp, Beauchamp, Lisa, Wooters, Joe, Tilton, John C., Long, Eric O., Watzl, Carsten

“…Triggering of 2B4 (CD244) can induce natural killer (NK)-cell activation, costimulation, or even inhibition of NK-cell activity. Here, we investigate the…”
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Global phosphoproteomics of CCR5-tropic HIV-1 signaling reveals reprogramming of cellular protein production pathways and identifies p70-S6K1 and MK2 as HIV-responsive kinases required for optimal infection of CD4+ T cells by Wiredja, Danica D, Tabler, Caroline O, Schlatzer, Daniela M, Li, Ming, Chance, Mark R, Tilton, John C

“…Viral reprogramming of host cells enhances replication and is initiated by viral interaction with the cell surface. Upon human immunodeficiency virus (HIV)…”
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HIV-1 Resistance to CCR5 Antagonists Associated with Highly Efficient Use of CCR5 and Altered Tropism on Primary CD4+ T Cells by Pfaff, Jennifer M, Wilen, Craig B, Harrison, Jessamina E, Demarest, James F, Lee, Benhur, Doms, Robert W, Tilton, John C

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COVID-19 and Cardiovascular Disease: From Bench to Bedside by Chung, Mina K., Zidar, David A., Bristow, Michael R., Cameron, Scott J., Chan, Timothy, Harding, Clifford V., Kwon, Deborah H., Singh, Tamanna, Tilton, John C., Tsai, Emily J., Tucker, Nathan R., Barnard, John, Loscalzo, Joseph

“…A pandemic of historic impact, coronavirus disease 2019 (COVID-19) has potential consequences on the cardiovascular health of millions of people who survive…”
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Primary Infection by a Human Immunodeficiency Virus with Atypical Coreceptor Tropism by CHUNLAI JIANG, PARRISH, Nicholas F, PFAFF, Jennifer M, HENNING, Elizabeth A, DECKER, Julie M, ANTHONY MOODY, M, DRINKER, Mark S, SCHUTTE, Robert, FREEL, Stephanie, TOMARAS, Georgia D, NEDELLEC, Rebecca, MOSIER, Donald E, WILEN, Craig B, HAYNES, Barton F, SHAW, George M, HAHN, Beatrice H, DOMS, Robert W, FENG GAO, HUI LI, YUE CHEN, PAVLICEK, Jeffrey W, BERG, Anna, XIAOZHI LU, HONGSHUO SONG, TILTON, John C

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Multifaceted Mechanisms of HIV Inhibition and Resistance to CCR5 Inhibitors PSC-RANTES and Maraviroc by LOBRITZ, Michael A, RATCLIFF, Annette N, MAROZSAN, Andre J, DUDLEY, Dawn M, TILTON, John C, ARTS, Eric J

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Human Immunodeficiency Virus Viremia Induces Plasmacytoid Dendritic Cell Activation In Vivo and Diminished Alpha Interferon Production In Vitro by TILTON, John C, MANION, Maura M, LIFSON, Jeffrey D, METCALF, Julia A, LEMPICKI, Richard A, CONNORS, Mark, LUSKIN, Marlise R, JOHNSON, Alison J, PATAMAWENU, Andy A, HALLAHAN, Claire W, COGLIANO-SHUTTA, Nancy A, MICAN, Joann M, DAVEY, Richard T, KOTTILIL, Shyam

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Changes in Paracrine Interleukin-2 Requirement, CCR7 Expression, Frequency, and Cytokine Secretion of Human Immunodeficiency Virus-Specific CD4+ T Cells Are a Consequence of Antigen Load by TILTON, John C, LUSKIN, Marlise R, JOHNSON, Alison J, MANION, Maura, HALLAHAN, Claire W, METCALF, Julia A, MCLAUGHLIN, Mary, DAVEY, Richard T, CONNORS, Mark

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HIV: cell binding and entry by Wilen, Craig B, Tilton, John C, Doms, Robert W

“…The first step of the human immunodeficiency virus (HIV) replication cycle-binding and entry into the host cell-plays a major role in determining viral tropism…”
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Diminished Proliferation of Human Immunodeficiency Virus-Specific CD4+ T Cells Is Associated with Diminished Interleukin-2 (IL-2) Production and Is Recovered by Exogenous IL-2 by Iyasere, Christiana, Tilton, John C, Johnson, Alison J, Younes, Souheil, Yassine-Diab, Bader, Sekaly, Rafick-Pierre, Kwok, William W, Migueles, Stephen A, Laborico, Alisha C, Shupert, W Lesley, Hallahan, Claire W, Davey, Jr, Richard T, Dybul, Mark, Vogel, Susan, Metcalf, Julia, Connors, Mark

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Entry inhibitors and their use in the treatment of HIV-1 infection by Haqqani, Aiman A., Tilton, John C.

“…•Entry inhibitors are a diverse group of drugs targeting various stages of HIV entry.•Maraviroc and enfuvirtide are approved for the treatment of infected…”
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The HIV-1 Viral Protease Is Activated during Assembly and Budding Prior to Particle Release by Tabler, Caroline O, Wegman, Sarah J, Chen, Jiji, Shroff, Hari, Alhusaini, Najwa, Tilton, John C

“…HIV-1 encodes a viral protease that is essential for the maturation of infectious viral particles. While protease inhibitors are effective antiretroviral…”
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