Search Results - "Tilstra, Jeremy"

B cell-intrinsic TLR9 expression is protective in murine lupus by Tilstra, Jeremy S, John, Shinu, Gordon, Rachael A, Leibler, Claire, Kashgarian, Michael, Bastacky, Sheldon, Nickerson, Kevin M, Shlomchik, Mark J

“…Toll-like receptor 9 (TLR9) is a regulator of disease pathogenesis in systemic lupus erythematosus (SLE). Why TLR9 represses disease while TLR7 and MyD88 have…”
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Rheumatoid Nodules by Tilstra, Jeremy S., MD, PhD, Lienesch, Douglas W., MD

“…Rheumatoid nodules are a common manifestation of rheumatoid arthritis. These lesions are often easily identified based on typical diagnostic features and…”
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Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted by Tilstra, Jeremy S, Avery, Lyndsay, Menk, Ashley V, Gordon, Rachael A, Smita, Shuchi, Kane, Lawrence P, Chikina, Maria, Delgoffe, Greg M, Shlomchik, Mark J

“…While T cells are important for the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis, little is known about how T cells function after…”
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B cell-intrinsic Myd88 regulates disease progression in murine lupus by Tilstra, Jeremy S, Kim, Minjung, Gordon, Rachael A, Leibler, Claire, Cosgrove, Haylee A, Bastacky, Sheldon, Nickerson, Kevin M, Shlomchik, Mark J

“…Nucleic acid-specific Toll-like receptors (TLRs) have been implicated in promoting disease pathogenesis in systemic lupus erythematosus (SLE). Whether such…”
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NF-κB in Aging and Disease by Tilstra, Jeremy S, Clauson, Cheryl L, Niedernhofer, Laura J, Robbins, Paul D

“…Stochastic damage to cellular macromolecules and organelles is thought to be a driving force behind aging and associated degenerative changes. However, stress…”
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NF-κB inhibition delays DNA damage-induced senescence and aging in mice by Tilstra, Jeremy S, Robinson, Andria R, Wang, Jin, Gregg, Siobhán Q, Clauson, Cheryl L, Reay, Daniel P, Nasto, Luigi A, St Croix, Claudette M, Usas, Arvydas, Vo, Nam, Huard, Johnny, Clemens, Paula R, Stolz, Donna B, Guttridge, Denis C, Watkins, Simon C, Garinis, George A, Wang, Yinsheng, Niedernhofer, Laura J, Robbins, Paul D

“…The accumulation of cellular damage, including DNA damage, is thought to contribute to aging-related degenerative changes, but how damage drives aging is…”
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Murine lupus is neutrophil elastase-independent in the MRL.Faslpr model by Gordon, Rachael A, Tilstra, Jeremy S, Marinov, Anthony, Nickerson, Kevin M, Bastacky, Sheldon I, Shlomchik, Mark J

“…Loss of tolerance to nuclear antigens and multisystem tissue destruction is a hallmark of systemic lupus erythematosus (SLE). Although the source of…”
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B cell-intrinsic TLR7 expression drives severe lupus in TLR9-deficient mice by Cosgrove, Haylee A, Gingras, Sebastien, Kim, Minjung, Bastacky, Sheldon, Tilstra, Jeremy S, Shlomchik, Mark J

“…The endosomal Toll-like receptor 7 (TLR7) is a major driver of murine and human systemic lupus erythematosus (SLE). The role of TLR7 in lupus pathogenesis is…”
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Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis by Pandey, Surya P, Bender, Mackenzie J, McPherson, Alex C, Phelps, Catherine M, Sanchez, Luzmariel Medina, Rana, Mohit, Hedden, Lee, Sangani, Kishan A, Chen, Li, Shapira, Jake H, Siller, Magdalena, Goel, Chhavi, Verdú, Elena F, Jabri, Bana, Chang, Alexander, Chandran, Uma R, Mullett, Steven J, Wendell, Stacy G, Singhi, Aatur D, Tilstra, Jeremy S, Pierre, Joseph F, Arteel, Gavin E, Hinterleitner, Reinhard, Meisel, Marlies

“…The triggers that drive interferon-γ (IFNγ)-producing CD8 T cell (Tc1 cell)-mediated autoimmune hepatitis (AIH) remain obscure. Here, we show that lack of…”
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Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model by Lavasani, Mitra, Robinson, Andria R., Lu, Aiping, Song, Minjung, Feduska, Joseph M., Ahani, Bahar, Tilstra, Jeremy S., Feldman, Chelsea H., Robbins, Paul D., Niedernhofer, Laura J., Huard, Johnny

“…With ageing, there is a loss of adult stem cell function. However, there is no direct evidence that this has a causal role in ageing-related decline. We tested…”
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205 Local tissue microenvironment regulates T cell phenotypes in murine systemic lupus erythematosus by Shuchi, Smita, Shlomchik, Mark, Kim, Minjung, Tilstra, Jeremy

“…BackgroundT cells play a significant role in the pathogenesis and end-organ damage observed in systemic lupus erythematosus (SLE). Previous studies using…”
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Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis by Davé, Shaival H, Tilstra, Jeremy S, Matsuoka, Katsuyoshi, Li, Fengling, DeMarco, Richard A, Beer-Stolz, Donna, Sepulveda, Antonia R, Fink, Mitchell P, Lotze, Michael T, Plevy, Scott E

“…In two murine models of the human inflammatory bowel diseases, treatment with ethyl pyruvate ameliorated multiple features of active colitis, possibly by…”
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ISSLS Prize Winner: Inhibition of NF-κB Activity Ameliorates Age-Associated Disc Degeneration in a Mouse Model of Accelerated Aging by NASTO, Luigi A, SEO, Hyoung-Yeon, NIEDERNHOFER, Laura J, KANG, James D, ROBBINS, Paul D, VO, Nam V, ROBINSON, Andria R, TILSTRA, Jeremy S, CLAUSON, Cheryl L, SOWA, Gwendolyn A, NGO, Kevin, QING DONG, POLA, Enrico, LEE, Joon Y

“…NF-κB activity was pharmacologically and genetically blocked in an accelerated aging mouse model to mitigate age-related disc degenerative changes. To study…”
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Heterogeneity and clonality of kidney-infiltrating T cells in murine lupus nephritis by Smita, Shuchi, Chikina, Maria, Shlomchik, Mark J, Tilstra, Jeremy S

“…We previously found that kidney-infiltrating T cells (KITs) in murine lupus nephritis (LN) resembled dysfunctional T cells that infiltrate tumors. This…”
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Enteroendocrine cells express functional Toll-like receptors by Bogunovic, Milena, Davé, Shaival H, Tilstra, Jeremy S, Chang, Diane T W, Harpaz, Noam, Xiong, Huabao, Mayer, Lloyd F, Plevy, Scott E

“…Intestinal epithelial cells (IECs) provide a physical and immunological barrier against enteric microbial flora. Toll-like receptors (TLRs), through…”
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1114 Parenchymal INFγ Response Regulates Murine Lupus Nephritis in a PD-L1 Independent Fashion by Kim, Minjung, Marinov, Anthony, Shlomchik, Mark, Tilstra, Jeremy

“…Background/PurposeLupus nephritis is the most common life-threatening end-organ complication of SLE. Interstitial infiltrates, specifically T cells, are major…”
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505 Parenchymal INFγ response regulates murine lupus nephritis by Kim, Minjung, Marinov, Anthony, Shlomchik, Mark, Tilstra, Jeremy

“…BackgroundLupus nephritis is the most common life-threatening end-organ complication of SLE. Interstitial infiltrates, specifically T cells, are major…”
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Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model by Lavasani, Mitra, Robinson, Andria R., Lu, Aiping, Song, Minjung, Feduska, Joseph M., Ahani, Bahar, Tilstra, Jeremy S., Feldman, Chelsea H., Robbins, Paul D., Niedernhofer, Laura J., Huard, Johnny

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NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7 by Gordon, Rachael A, Cosgrove, Haylee A, Marinov, Anthony, Gingras, Sebastien, Tilstra, Jeremy S, Campbell, Allison M, Bastacky, Sheldon I, Kashgarian, Michael, Perl, Andras, Nickerson, Kevin M, Shlomchik, Mark J

“…Loss of NADPH oxidase (NOX2) exacerbates systemic lupus erythematosus (SLE) in mice and humans, but the mechanisms underlying this effect remain unclear. To…”
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NF-κB Negatively Impacts the Myogenic Potential of Muscle-derived Stem Cells by Lu, Aiping, Proto, Jonathan D, Guo, Lulin, Tang, Ying, Lavasani, Mitra, Tilstra, Jeremy S, Niedernhofer, Laura J, Wang, Bing, Guttridge, Denis C, Robbins, Paul D, Huard, Johnny

“…Inhibition of the inhibitor of kappa B kinase (IKK)/nuclear factor-kappa B (NF-κB) pathway enhances muscle regeneration in injured and diseased skeletal…”
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