Search Results - "Tilney, N. L."

Brain death and its influence on donor organ quality and outcome after transplantation by PRATSCHKE, J, WILHELM, M. J, KUSAKA, M, BASKER, M, COOPER, D. K. C, HANCOCK, W. W, TILNEY, N. L

“…Transplantation has evolved as the treatment of choice for many patients with end-stage organ disease. However, despite the >80% one-year functional survival…”
Get full text

Accelerated rejection of renal allografts from brain-dead donors by PRATSCHKE, J, WILHELM, M. J, KUSAKA, M, BEATO, F, MILFORD, E. L, HANCOCK, W. W, TILNEY, N. L

“…To define the potential influences of donor brain death on organs used for transplantation. Donor brain death causes prompt upregulation of inflammatory…”
Get full text

The cytokine-adhesion molecule cascade in ischemia/reperfusion injury of the rat kidney. Inhibition by a soluble P-selectin ligand by Takada, M, Nadeau, K C, Shaw, G D, Marquette, K A, Tilney, N L

“…Ischemia/reperfusion (I/R) injury associated with renal transplantation may influence both early graft function and late changes. The initial (</= 7 d) events…”
Get full text

A model of gradual onset brain death for transplant-associated studies in rats by PRATSCHKE, J, WILHELM, M. J, KUSAKA, M, LASKOWSKI, I, TILNEY, N. L

“…The relatively few studies that have examined the systemic events after brain death have primarily involved large animals. For more precise definition of the…”
Get full text

Effects of explosive brain death on cytokine activation of peripheral organs in the rat by TAKADA, M, NADEAU, K. C, HANCOCK, W. W, MACKENZIE, H. S, SHAW, G. D, WAAGA, A. M, CHANDRAKER, A, SAYEGH, M. H, TILNEY, N. L

“…The success rate of transplanted organs from brain-dead cadaver donors is consistently inferior to that of living sources. As cadaver and living unrelated…”
Get full text

Activation of the heart by donor brain death accelerates acute rejection after transplantation by WILHELM, Markus J, PRATSCHKE, Johann, BEATO, Francisca, TAAL, Maarten, KUSAKA, Mamoru, HANCOCK, Wayne W, TILNEY, Nicholas L

“…Donor brain death upregulates expression of inflammatory mediators in the heart. It is hypothesized that these nonspecific changes trigger and amplify acute…”
Get full text

Cellular and molecular predictors of chronic renal dysfunction after initial ischemia/reperfusion injury of a single kidney by AZUMA, H, NADEAU, K, TAKADA, M, MACKENZIE, H. S, TILNEY, N. L

“…Initial ischemia/reperfusion injury occurring secondary to organ retrieval, storage, and transplantation has been associated with late renal allograft…”
Get full text

Activation of inflammatory mediators in rat renal isografts by donor brain death by KUSAKA, M, PRATSCHKE, J, WILHELM, M. J, ZIAI, F, ZANDI-NEJAD, K, MACKENZIE, H. S, HANCOCK, W. W, TILNEY, N. L

“…Brain death (BD) has been thought to influence the early course of transplanted organs by triggering a series of nonspecific inflammatory events that in turn…”
Get full text

The role of the B7 costimulatory pathway in experimental cold ischemia/reperfusion injury by Takada, M, Chandraker, A, Nadeau, K C, Sayegh, M H, Tilney, N L

“…Ischemia/reperfusion injury associated with organ retrieval and storage influences the development of chronic graft dysfunction, the major clinical problem in…”
Get full text

A Semi‐Centennial Report on the Participants Depicted in Joel Babb's Portrait, ‘The First Successful Kidney Transplantation' by Desai, S. P., Desai, M. S., Wood, D. N., Maddi, R., Leeson, S., Tilney, N. L.

“…Joseph Murray performed the first successful human kidney transplant on December 23, 1954. Forty‐three years later, he along with participants Francis Moore…”
Get full text

Chronic rejection--an undefined conundrum by Tilney, N L, Whitley, W D, Diamond, J R, Kupiec-Weglinski, J W, Adams, D H

Get more information

Late consequences of acute ischemic injury to a solitary kidney by PAGTALUNAN, M. E, OLSON, J. L, TILNEY, N. L, MEYER, T. W

“…The sequelae of acute ischemic injury to a solitary kidney were assessed in rats subjected to right nephrectomy and transient occlusion of the left renal…”
Get full text

Sequential Cytokine Dynamics in Chronic Rejection of Rat Renal Allografts: Roles for Cytokines RANTES and MCP-1 by Nadeau, Kari C., Azuma, Haruhito, Tilney, Nicholas L.

“…Chronic rejection, the most important cause of long-term graft failure, is thought to result from both alloantigen-dependent and -independent factors. To…”
Get full text

Coronary arteriosclerosis after T-cell-mediated injury in transplanted mouse hearts: role of interferon-gamma by Nagano, H, Libby, P, Taylor, MK, Hasegawa, S, Stinn, JL, Becker, G, Tilney, NL, Mitchell, RN

“…This study evaluated the contribution of acute parenchymal rejection and interferon (IFN)-gamma to the development of graft arterial disease (GAD) in totally…”
Get full text

Influence of donor brain death on chronic rejection of renal transplants in rats by PRATSCHKE, Johann, WILHELM, Markus J, LASKOWSKI, Igor, KUSAKA, Mamoru, BEATO, Francisca, TULLIUS, Stefan G, NEUHAUS, Peter, HANCOCK, Wayne W, TILNEY, Nicholas L

“…The clinical observation that the results of kidney grafts from living donors (LD), regardless of relationship with the host, are consistently superior to…”
Get full text

Blockade of T-Cell Costimulation Prevents Development of Experimental Chronic Renal Allograft Rejection by Azuma, Haruhito, Chandraker, Anil, Nadeau, Kari, Hancock, Wayne W., Carpenter, Charles B., Tilney, Nicholas L., Sayegh, Mohamed H.

“…Blocking CD28-B7 T-cell costimulation by systemic administration of CTLA4Ig, a fusion protein which binds B7 molecules on the surface of antigen-presenting…”
Get full text

The commercialization of transplantation by Tilney, N.L

Get full text

The contribution of reduced functioning mass to chronic kidney allograft dysfunction in rats by Heemann, U W, Azuma, H, Tullius, S G, Mackenzie, H, Brenner, B M, Tilney, N L

“…Chronic renal allograft dysfunction may become manifest months or years after transplantation by progressive functional deterioration associated with…”
Get more information

Sequential cellular and molecular kinetics in acutely rejecting renal allografts in rats by NAGANO, H, NADEAU, K. C, TAKADA, M, KUSAKA, M, TILNEY, N. L

“…The initial (0-24 hr), early (3-5 days), and late (7-14 days) events occurring in LBNF1 renal allografts transplanted into Lew recipients were examined to…”
Get full text

Prevention of late renal changes after initial ischemia/reperfusion injury by blocking early selectin binding by TAKADA, M, NADEAU, K. C, SHAW, G. D, TILNEY, N. L

“…Increasing clinical evidence suggests that delayed initial function secondary to ischemia/reperfusion injury alone, and particularly in combination with early…”
Get full text