Search Results - "Tilly, K. I."

Estradiol-Mediated Suppression of Apoptosis in the Rabbit Corpus Luteum Is Associated with a Shift in Expression of bcl-2 Family Members Favoring Cellular Survival by GOODMAN, S. B, KUGU, K, CHEN, S. H, PREUTTHIPAN, S, TILLY, K. I, TILLY, J. L, DHARMARAJAN, A. M

“…In the rabbit, estradiol is the primary luteotropic hormone. Estradiol withdrawal results in a rapid decline in serum progesterone and eventually in corpus…”
Get full text

Differential expression of members of the bcl-2 gene family in proliferative and secretory human endometrium : Glandular epithelial cell apoptosis is associated with increased expression of bax by TAO, X.-J, TILLY, K. I, MARAVEI, D. V, SHIFREN, J. L, KRAJEWSKI, S, REED, J. C, TILLY, J. L, ISAACSON, K. B

“…Glandular epithelial cells of the human endometrium initiate apoptosis in the secretory phase of the cycle. To better understand the regulation of apoptosis in…”
Get full text

Activin inhibits basal and androgen-stimulated proliferation and induces apoptosis in the human prostatic cancer cell line, LNCaP by Wang, Q F, Tilly, K I, Tilly, J L, Preffer, F, Schneyer, A L, Crowley, W F, Sluss, P M

“…LNCaP cells, derived from an androgen-sensitive cell line widely employed as an in vitro model of human prostate cancer, have been shown to express activin…”
Get full text

A program of cell death and extracellular matrix degradation is activated in the amnion before the onset of labor by Lei, H, Furth, E E, Kalluri, R, Chiou, T, Tilly, K I, Tilly, J L, Elkon, K B, Jeffrey, J J, Strauss, 3rd, J F

“…Fetal membranes usually rupture during the process of labor. Premature fetal membrane rupture occurs not infrequently and is associated with significant fetal…”
Get full text

Role of apoptosis in functional luteolysis in the pregnant rabbit corpus luteum: evidence of a role for placental-derived factors in promoting luteal cell survival by Dharmarajan, A M, Goodman, S B, Atiya, N, Parkinson, S P, Lareu, R R, Tilly, K I, Tilly, J L

“…Corpora lutea (CL) were isolated from one rabbit ovary on days 4, 8, 16 (peak luteal function), 28 (functional regression) and 30 of pregnancy and processed…”
Get full text

Expression of the p53 and Wilms' tumor suppressor genes in the rat ovary: gonadotropin repression in vivo and immunohistochemical localization of nuclear p53 protein to apoptotic granulosa cells of atretic follicles by Tilly, K I, Banerjee, S, Banerjee, P P, Tilly, J L

“…We have previously demonstrated that the gonadotropin-mediated inhibition of apoptosis in ovarian granulosa cells is linked to changes in the expression of…”
Get more information

Inhibitors of oxidative stress mimic the ability of follicle-stimulating hormone to suppress apoptosis in cultured rat ovarian follicles by Tilly, J L, Tilly, K I

“…We have reported that members of the bcl-2 gene family are expressed and gonadotropin regulated in ovarian granulosa cells during follicular maturation and…”
Get more information

Targeted expression of Bcl-2 in mouse oocytes inhibits ovarian follicle atresia and prevents spontaneous and chemotherapy-induced oocyte apoptosis in vitro by Morita, Y, Perez, G I, Maravei, D V, Tilly, K I, Tilly, J L

“…Members of the Bcl-2 family serve as central checkpoints for cell death regulation, and overexpression of Bcl-2 is known to inhibit apoptosis in many cell…”
Get full text

Models to elucidate the regulation of adrenal cell death by Carsia, R. V., Nagele, R. G., Morita, Y., Tilly, K. I., Tilly, J. L.

“…Hypophysectomy-induced apoptosis in the rat adrenal gland is slow (not apparent until 12-24 h) and in-situ, 3′-end labeling (ISEL) of DNA strand breaks is…”
Get full text

Antioxidants mimic the ability of chorionic gonadotropin to suppress apoptosis in the rabbit corpus luteum in vitro: a novel role for superoxide dismutase in regulating bax expression by Dharmarajan, A M, Hisheh, S, Singh, B, Parkinson, S, Tilly, K I, Tilly, J L

“…We have recently reported that members of the bcl-2 gene family are expressed and estradiol regulated in rabbit luteal cells during corpus luteum (CL)…”
Get full text

Analysis of apoptosis and expression of bcl-2 gene family members in the human and baboon ovary by Kugu, K, Ratts, V S, Piquette, G N, Tilly, K I, Tao, X J, Martimbeau, S, Aberdeen, G W, Krajewski, S, Reed, J C, Pepe, G J, Albrecht, E D, Tilly, J L

“…Recent data support a role for apoptosis, under tight regulatory control by bcl-2, oxidative stress response, tumor suppressor, and CASP gene family members,…”
Get full text

Localization, regulation and possible consequences of apoptotic protease-activating factor-1 (Apaf-1) expression in granulosa cells of the mouse ovary by Robles, R, Tao, X J, Trbovich, A M, Maravel, D V, Nahum, R, Perez, G I, Tilly, K I, Tilly, J L

“…The recent characterization of apoptotic protease-activating factor-1 (Apaf-1) in vertebrates as a putative homolog of the Caenorhabditis elegans gene, ced-4,…”
Get full text

Increased bax and interleukin-1 β-converting enzyme messenger ribonucleic acid levels coincide with apoptosis in the bovine corpus luteum during structural regression by RUEDA, B. R, TILLY, K. I, BOTROS, I. W, JOLLY, P. D, HANSEN, T. R, HOYER, P. B, TILLY, J. L

“…Recent reports have demonstrated that prostaglandin F sub(2 alpha )-induced generation of reactive oxygen species or their intermediates inhibits progesterone…”
Get full text

The genes of cell death and cellular susceptibility to apoptosis in the ovary: a hypothesis by Tilly, J L, Tilly, K I, Perez, G I

“…Recent advances in the field of cell death, primarily derived from gene-transfer experiments and manipulation of tumor cell lines in vitro, have identified key…”
Get full text

Interleukin-1 beta-converting enzyme-related proteases (IRPs) and mammalian cell death: dissociation of IRP-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle by Flaws, J A, Kugu, K, Trbovich, A M, DeSanti, A, Tilly, K I, Hirshfield, A N, Tilly, J L

“…The Caenorhabditis elegans death susceptibility gene, ced-3, has a number of homologs in vertebrate species, including interleukin-1 beta (IL-1…”
Get more information

Activin inhibits basal and androgen-stimulated proliferation and induces apoptosis in the human prostatic cancer cell line, LNCaP by Wang, Q F, Tilly, K I, Tilly, J L, Preffer, F, Schneyer, A L, Crowley, W F, Sluss, P M

“…LNCaP cells, derived from an androgen-sensitive cell line widely employed as an in vitro model of human prostate cancer, have been shown to express activin…”
Get full text

Lobe-specific apoptotic cell death in rat prostate after androgen ablation by castration by Banerjee, P P, Banerjee, S, Tilly, K I, Tilly, J L, Brown, T R, Zirkin, B R

“…It is well established that androgens are central to regulation of the growth of the mammalian prostate gland. Conversely, androgen deprivation by castration…”
Get more information

Vasoactive intestinal peptide-mediated suppression of apoptosis in the ovary: potential mechanisms of action and evidence of a conserved antiatretogenic role through evolution by Flaws, J A, DeSanti, A, Tilly, K I, Javid, R O, Kugu, K, Johnson, A L, Hirshfield, A N, Tilly, J L

“…Vasoactive intestinal peptide (VIP)-containing nerve fibers are present in ovarian follicles at all stages of development, and VIP, acting primarily via the…”
Get more information

Cleavage of cytoskeletal proteins by caspases during ovarian cell death: evidence that cell-free systems do not always mimic apoptotic events in intact cells by Maravei, D V, Trbovich, A M, Perez, G I, Tilly, K I, Banach, D, Talanian, R V, Wong, W W, Tilly, J L

“…Several lines of evidence support a role for protease activation during apoptosis. Herein, we investigated the involvement of several members of the CASP…”
Get full text

Expression of superoxide dismutase, catalase and glutathione peroxidase in the bovine corpus luteum: evidence supporting a role for oxidative stress in luteolysis by Rueda, B R, Tilly, K I, Hansen, T R, Hoyer, P B, Tilly, J L

“…Apoptosis, a type of physiological or active cell death, has been implicated as a mechanism underlying regression of the corpus luteum (CL) in the rat, bovine,…”
Get full text