Search Results - "Tillu, Dipti V"

Extracellular phosphorylation of a receptor tyrosine kinase controls synaptic localization of NMDA receptors and regulates pathological pain by Hanamura, Kenji, Washburn, Halley R, Sheffler-Collins, Sean I, Xia, Nan L, Henderson, Nathan, Tillu, Dipti V, Hassler, Shayne, Spellman, Daniel S, Zhang, Guoan, Neubert, Thomas A, Price, Theodore J, Dalva, Matthew B

“…Extracellular phosphorylation of proteins was suggested in the late 1800s when it was demonstrated that casein contains phosphate. More recently, extracellular…”
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IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex by Melemedjian, Ohannes K, Asiedu, Marina N, Tillu, Dipti V, Peebles, Katherine A, Yan, Jin, Ertz, Natalie, Dussor, Gregory O, Price, Theodore J

“…Despite the emergence of translational control pathways as mediators of nociceptive sensitization, effector molecules and mechanisms responsible for modulating…”
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Resveratrol Engages AMPK to Attenuate ERK and mTOR Signaling in Sensory Neurons and Inhibits Incision-Induced Acute and Chronic Pain by Tillu, Dipti V, Melemedjian, Ohannes K, Asiedu, Marina N, Qu, Ning, De Felice, Milena, Dussor, Gregory, Price, Theodore J

“…Background: Despite advances in our understanding of basic mechanisms driving post-surgical pain, treating incision-induced pain remains a major clinical…”
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Targeting Adenosine Monophosphate-Activated Protein Kinase (AMPK) in Preclinical Models Reveals a Potential Mechanism for the Treatment of Neuropathic Pain by Melemedjian, Ohannes K, Asiedu, Marina N, Tillu, Dipti V, Sanoja, Raul, Yan, Jin, Lark, Arianna, Khoutorsky, Arkady, Johnson, Jessica, Peebles, Katherine A, Lepow, Talya, Sonenberg, Nahum, Dussor, Gregory, Price, Theodore J

“…Neuropathic pain is a debilitating clinical condition with few efficacious treatments, warranting development of novel therapeutics. We hypothesized that…”
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Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism by Kim, Ji-Young V, Tillu, Dipti V, Quinn, Tammie L, Mejia, Galo L, Shy, Adia, Asiedu, Marina N K, Murad, Elaine, Schumann, Alan P, Totsch, Stacie K, Sorge, Robert E, Mantyh, Patrick W, Dussor, Gregory, Price, Theodore J

“…The mechanisms that lead to the maintenance of chronic pain states are poorly understood, but their elucidation could lead to new insights into how pain…”
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Protease-activated receptor 2 activation is sufficient to induce the transition to a chronic pain state by Tillu, Dipti V., Hassler, Shayne N., Burgos-Vega, Carolina C., Quinn, Tammie L., Sorge, Robert E., Dussor, Gregory, Boitano, Scott, Vagner, Josef, Price, Theodore J.

“…Protease-activated receptor type 2 (PAR2) is known to play an important role in inflammatory, visceral, and cancer-evoked pain based on studies using PAR2…”
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Correction: Extracellular phosphorylation of a receptor tyrosine kinase controls synaptic localization of NMDA receptors and regulates pathological pain by Hanamura, Kenji, Washburn, Halley R., Sheffler-Collins, Sean I., Xia, Nan L., Henderson, Nathan, Tillu, Dipti V., Hassler, Shayne, Spellman, Daniel S., Zhang, Guoan, Neubert, Thomas A., Price, Theodore J., Dalva, Matthew B.

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Development and evaluation of small peptidomimetic ligands to protease-activated receptor-2 (PAR2) through the use of lipid tethering by Boitano, Scott, Hoffman, Justin, Tillu, Dipti V, Asiedu, Marina N, Zhang, Zhenyu, Sherwood, Cara L, Wang, Yan, Dong, Xinzhong, Price, Theodore J, Vagner, Josef

“…Protease-activated receptor-2 (PAR2) is a G-Protein Coupled Receptor (GPCR) activated by proteolytic cleavage to expose an attached, tethered ligand (SLIGRL)…”
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Temporal and sex differences in the role of BDNF/TrkB signaling in hyperalgesic priming in mice and rats by Moy, Jamie K, Szabo-Pardi, Thomas, Tillu, Dipti V, Megat, Salim, Pradhan, Grishma, Kume, Moeno, Asiedu, Marina N, Burton, Michael D, Dussor, Gregory, Price, Theodore J

“…Highlights • The effect of TrkB-Fc on hyperalgesic priming is sexually dimorphic in mice. • The effect of TrkB-Fc on hyperalgesic priming is equivalent in male…”
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Pharmacological activation of AMPK inhibits incision-evoked mechanical hypersensitivity and the development of hyperalgesic priming in mice by Burton, Michael D., Tillu, Dipti V., Mazhar, Khadijah, Mejia, Galo L., Asiedu, Marina N., Inyang, Kufreobong, Hughes, Travis, Lian, Bo, Dussor, Gregory, Price, Theodore J.

“…[Display omitted] •A novel resveratrol-based topical cream alleviates acute postoperative pain and hyperalgesic priming.•Combination treatments of resveratrol…”
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Spinal protein kinase M ζ underlies the maintenance mechanism of persistent nociceptive sensitization by Asiedu, Marina N, Tillu, Dipti V, Melemedjian, Ohannes K, Shy, Adia, Sanoja, Raul, Bodell, Bryce, Ghosh, Sourav, Porreca, Frank, Price, Theodore J

“…Sensitization of the pain pathway is believed to promote clinical pain disorders. We hypothesized that the persistence of a sensitized state in the spinal…”
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Local Translation and Retrograde Axonal Transport of CREB Regulates IL-6-Induced Nociceptive Plasticity by Melemedjian, Ohannes K, Tillu, Dipti V, Moy, Jamie K, Asiedu, Marina N, Mandell, Edward K, Ghosh, Sourav, Dussor, Gregory, Price, Theodore J

“…Transcriptional regulation of genes by cyclic AMP response element binding protein (CREB) is essential for the maintenance of long-term memory. Moreover,…”
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The novel PAR2 ligand C391 blocks multiple PAR2 signalling pathways in vitro and in vivo by Boitano, Scott, Hoffman, Justin, Flynn, Andrea N, Asiedu, Marina N, Tillu, Dipti V, Zhang, Zhenyu, Sherwood, Cara L, Rivas, Candy M, DeFea, Kathryn A, Vagner, Josef, Price, Theodore J

“…Background and Purpose Proteinase‐activated receptor‐2 (PAR2) is a GPCR linked to diverse pathologies, including acute and chronic pain. PAR2 is one of the…”
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BDNF Regulates Atypical PKC at Spinal Synapses to Initiate and Maintain a Centralized Chronic Pain State by Melemedjian, Ohannes K, Tillu, Dipti V, Asiedu, Marina N, Mandell, Edward K, Moy, Jamie K, Blute, Victoria M, Taylor, Caleb J, Ghosh, Sourav, Price, Theodore J

“…Background Chronic pain is an important medical problem affecting hundreds of millions of people worldwide. Mechanisms underlying the maintenance of chronic…”
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Lanthanide Labeling of a Potent Protease Activated Receptor‑2 Agonist for Time-Resolved Fluorescence Analysis by Hoffman, Justin, Flynn, Andrea N, Tillu, Dipti V, Zhang, Zhenyu, Patek, Renata, Price, Theodore J, Vagner, Josef, Boitano, Scott

“…Protease activated receptor-2 (PAR2) is one of four G-protein coupled receptors (GPCRs) that can be activated by exogenous or endogenous proteases, which…”
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Development of highly potent protease‐activated receptor 2 agonists via synthetic lipid tethering by Flynn, Andrea N., Hoffman, Justin, Tillu, Dipti V., Sherwood, Cara L., Zhang, Zhenyu, Patek, Renata, Asiedu, Marina N. K., Vagner, Josef, Price, Theodore J., Boitano, Scott

“…Protease‐activated receptor‐2 (PAR2) is a G‐protein coupled receptor (GPCR) associated with a variety of pathologies. However, the therapeutic potential of…”
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The Protease-activated Receptor-2-specific Agonists 2-Aminothiazol-4-yl-LIGRL-NH2 and 6-Aminonicotinyl-LIGRL-NH2 Stimulate Multiple Signaling Pathways to Induce Physiological Responses in Vitro and in Vivo by Flynn, Andrea N., Tillu, Dipti V., Asiedu, Marina N., Hoffman, Justin, Vagner, Josef, Price, Theodore J., Boitano, Scott

“…Protease-activated receptor-2 (PAR2) is one of four protease-activated G-protein-coupled receptors. PAR2 is expressed on multiple cell types where it…”
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Spinal Dopaminergic Projections Control the Transition to Pathological Pain Plasticity via a D 1 /D 5 -Mediated Mechanism by Kim, Ji-Young V., Tillu, Dipti V., Quinn, Tammie L., Mejia, Galo L., Shy, Adia, Asiedu, Marina N.K., Murad, Elaine, Schumann, Alan P., Totsch, Stacie K., Sorge, Robert E., Mantyh, Patrick W., Dussor, Gregory, Price, Theodore J.

“…The mechanisms that lead to the maintenance of chronic pain states are poorly understood, but their elucidation could lead to new insights into how pain…”
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Correction: Extracellular phosphorylation of a receptor tyrosine kinase controls synaptic localization of NMDA receptors and regulates pathological pain by Kenji Hanamura, Halley R Washburn, Sean I Sheffler-Collins, Nan L Xia, Nathan Henderson, Dipti V Tillu, Shayne Hassler, Daniel S Spellman, Guoan Zhang, Thomas A Neubert, Theodore J Price, Matthew B Dalva

“…[This corrects the article DOI: 10.1371/journal.pbio.2002457.]…”
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The novel PAR 2 ligand C 391 blocks multiple PAR 2 signalling pathways in vitro and in vivo by Boitano, Scott, Hoffman, Justin, Flynn, Andrea N, Asiedu, Marina N, Tillu, Dipti V, Zhang, Zhenyu, Sherwood, Cara L, Rivas, Candy M, DeFea, Kathryn A, Vagner, Josef, Price, Theodore J

“…Background and Purpose Proteinase‐activated receptor‐2 ( PAR 2) is a GPCR linked to diverse pathologies, including acute and chronic pain. PAR 2 is one of the…”
Get full text