Search Results - "Tillman, J"

FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases by Tillman, Erik J, Rolph, Tim

“…The rising global prevalence of obesity, metabolic syndrome, and type 2 diabetes has driven a sharp increase in non-alcoholic fatty liver disease (NAFLD),…”
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Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial by Harrison, Stephen A., Ruane, Peter J., Freilich, Bradley L., Neff, Guy, Patil, Rashmee, Behling, Cynthia A., Hu, Chen, Fong, Erica, de Temple, Brittany, Tillman, Erik J., Rolph, Timothy P., Cheng, Andrew, Yale, Kitty

“…Preclinical and clinical data suggest that fibroblast growth factor 21 (FGF21) is anti-fibrotic, improves metabolic status and has potential to treat…”
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AKR-001, an Fc-FGF21 Analog, Showed Sustained Pharmacodynamic Effects on Insulin Sensitivity and Lipid Metabolism in Type 2 Diabetes Patients by Kaufman, Allegra, Abuqayyas, Lubna, Denney, William S., Tillman, Erik J., Rolph, Tim

“…Experimental fibroblast growth factor 21 (FGF21) analogs can improve lipid profiles in patients with metabolic diseases. However, their effects on markers of…”
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Global transcriptional regulation of innate immunity by ATF-7 in C. elegans by Fletcher, Marissa, Tillman, Erik J, Butty, Vincent L, Levine, Stuart S, Kim, Dennis H

“…The nematode Caenorhabditis elegans has emerged as a genetically tractable animal host in which to study evolutionarily conserved mechanisms of innate immune…”
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Three months of high-fructose feeding fails to induce excessive weight gain or leptin resistance in mice by Tillman, Erik J, Morgan, Donald A, Rahmouni, Kamal, Swoap, Steven J

“…High-fructose diets have been implicated in obesity via impairment of leptin signaling in humans and rodents. We investigated whether fructose-induced leptin…”
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De-differentiation confers multidrug resistance via noncanonical PERK-Nrf2 signaling by Del Vecchio, Catherine A, Feng, Yuxiong, Sokol, Ethan S, Tillman, Erik J, Sanduja, Sandhya, Reinhardt, Ferenc, Gupta, Piyush B

“…Malignant carcinomas that recur following therapy are typically de-differentiated and multidrug resistant (MDR). De-differentiated cancer cells acquire MDR by…”
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Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters by Tolstorukov, Michael Y., Sansam, Courtney G., Lu, Ping, Koellhoffer, Edward C., Helming, Katherine C., Alver, Burak H., Tillman, Erik J., Evans, Julia A., Wilson, Boris G., Park, Peter J., Roberts, Charles W. M.

“…Precise nucleosome-positioning patterns at promoters are thought to be crucial for faithful transcriptional regulation. However, the mechanisms by which these…”
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A randomized trial comparing balloon kyphoplasty and vertebroplasty for vertebral compression fractures due to osteoporosis by Dohm, M, Black, C M, Dacre, A, Tillman, J B, Fueredi, G

“…Several trials have compared vertebral augmentation with nonsurgical treatment for vertebral compression fractures. This trial compares the efficacy and safety…”
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Effect of a centralized clinical pharmacy anticoagulation service on the outcomes of anticoagulation therapy by Witt, Daniel M, Sadler, Melanie A, Shanahan, Roberta L, Mazzoli, Georgann, Tillman, Donald J

“…A growing body of reports has documented the ability of anticoagulation management services to help patients receiving warfarin therapy achieve better outcomes…”
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DFT study of nano zinc/copper voltaic cells by Tillman Austin, J., Seminario, Jorge M.

“…To facilitate the development of new materials for use in batteries, it is necessary to develop ab initio full-electron computational techniques for modeling…”
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Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5 by Mora-Blanco, E L, Mishina, Y, Tillman, E J, Cho, Y-J, Thom, C S, Pomeroy, S L, Shao, W, Roberts, C W M

“…The SWI/SNF chromatin remodeling complex is a master regulator of developmental cell-fate decisions, although the key target pathways are poorly characterized…”
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Stabilization of Cardiac Ryanodine Receptor Prevents Intracellular Calcium Leak and Arrhythmias by Lehnart, Stephan E., Terrenoire, Cecile, Reiken, Steven, Wehrens, Xander H. T., Song, Long-Sheng, Tillman, Erik J., Mancarella, Salvatore, Coromilas, James, Lederer, W. J., Kass, Robert S., Marks, Andrew R.

“…Catecholaminergic polymorphic ventricular tachycardia is a form of exercise-induced sudden cardiac death that has been linked to mutations in the cardiac Ca²⁺…”
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Impact of Treatments on Diabetic Control and Gastrointestinal Symptoms After Total Pancreatectomy by Struyvenberg, Maarten R, Fong, Zhi Ven, Martin, Camilia R, Tseng, Jennifer F, Clancy, Thomas E, Fernández-Del Castillo, Carlos, Tillman, Hanna J, Bellin, Melena D, Freedman, Steven D

“…The aims of this study were to compare the safety, efficacy, and patients' quality of life with continuous subcutaneous insulin infusion (CSII) versus multiple…”
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A randomized trial comparing 2 techniques of balloon kyphoplasty and curette use for obtaining vertebral body height restoration and angular-deformity correction in vertebral compression fractures due to osteoporosis by Bastian, L, Schils, F, Tillman, J B, Fueredi, G

“…Vertebral compression fractures often result in pain and vertebral deformity. We compared 2 different balloon kyphoplasty techniques both using intraoperative…”
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DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells by TILLMAN, J. Erin, JIALING YUAN, GUANGYU GU, FAZLI, Ladan, GHOSH, Ritwik, FLYNT, Alex S, GLEAVE, Martin, RENNIE, Paul S, KASPER, Susan

“…The oncogene DJ-1 has been associated with multiple cancers, including prostate cancer, where it can be stabilized by androgens and antiandrogens. However,…”
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The impact of different health dimensions on overall quality of life related to kyphoplasty and non-surgical management by Borgström, F., Olafsson, G., Ström, O., Tillman, J. B., Wardlaw, D., Boonen, S., Miltenburger, C.

“…Summary This study uses data from a previously published randomised trial where balloon kyphoplasty was compared to non-surgical management. Of the improved…”
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Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumors by McKenna, Elizabeth S., Tamayo, Pablo, Cho, Yoon-Jae, Tillman, Erik J., Mora-Blanco, E. Lorena, Sansam, Courtney G., Koellhoffer, Edward C., Pomeroy, Scott L., Roberts, Charles W.M.

“…Emerging evidence demonstrates that subunits of the SWI/SNF chromatin remodeling complex are specifically mutated at high frequency in a variety of human…”
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Efruxifermin, a long‐acting Fc‐fusion FGF21 analogue, reduces body weight gain but does not increase sympathetic tone or urine volume in Sprague Dawley rats by Tillman, Erik J., Brock, William J., Rolph, Tim

“…Background and Purpose Analogues of fibroblast growth factor 21 (FGF21) demonstrate diverse metabolic benefits in preclinical models of type 2 diabetes,…”
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Does It Mix? by Kennon, J. Tillman, Fong, Bryant, Grippo, Anne

“…This article describes how by using three points to make a line and comparing the graphs for water and oil, students can mathematically demonstrate that…”
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Description of International Caenorhabditis elegans Experiment first flight (ICE-FIRST) by Szewczyk, N.J., Tillman, J., Conley, C.A., Granger, L., Segalat, L., Higashitani, A., Honda, S., Honda, Y., Kagawa, H., Adachi, R., Higashibata, A., Fujimoto, N., Kuriyama, K., Ishioka, N., Fukui, K., Baillie, D., Rose, A., Gasset, G., Eche, B., Chaput, D., Viso, M.

“…Traveling, living and working in space is now a reality. The number of people and length of time in space is increasing. With new horizons for exploration it…”
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