Search Results - "Tilley, Leann"

Artemisinin Action and Resistance in Plasmodium falciparum by Tilley, Leann, Straimer, Judith, Gnädig, Nina F, Ralph, Stuart A, Fidock, David A

“…The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in recent years to a substantial reduction in deaths resulting from…”
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K13, the Cytostome, and Artemisinin Resistance by Xie, Stanley C., Ralph, Stuart A., Tilley, Leann

“…Artemisinins – the frontline antimalarial drug class – are compromised by emerging resistance, putting at risk the lives of hundreds of thousands of people…”
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Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome by Bridgford, Jessica L., Xie, Stanley C., Cobbold, Simon A., Pasaje, Charisse Flerida A., Herrmann, Susann, Yang, Tuo, Gillett, David L., Dick, Lawrence R., Ralph, Stuart A., Dogovski, Con, Spillman, Natalie J., Tilley, Leann

“…Artemisinin and its derivatives (collectively referred to as ARTs) rapidly reduce the parasite burden in Plasmodium falciparum infections, and antimalarial…”
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Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins by Klonis, Nectarios, Creek, Darren J, Tilley, Leann

“…Graphical abstract…”
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Biochemical and cellular characterisation of the Plasmodium falciparum M1 alanyl aminopeptidase (PfM1AAP) and M17 leucyl aminopeptidase (PfM17LAP) by Mathew, Rency, Wunderlich, Juliane, Thivierge, Karine, Cwiklinski, Krystyna, Dumont, Claire, Tilley, Leann, Rohrbach, Petra, Dalton, John P.

“…The Plasmodium falciparum M1 alanyl aminopeptidase and M17 leucyl aminopeptidase, Pf M1AAP and Pf M17LAP, are potential targets for novel anti-malarial drug…”
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Structure- and function-based design of Plasmodium-selective proteasome inhibitors by Li, Hao, O’Donoghue, Anthony J., van der Linden, Wouter A., Xie, Stanley C., Yoo, Euna, Foe, Ian T., Tilley, Leann, Craik, Charles S., da Fonseca, Paula C. A., Bogyo, Matthew

“…Structural and functional characterizations show that the specificity of the Plasmodium falciparum proteasome is sufficiently unique from that of the human…”
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Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion by Klonis, Nectarios, Crespo-Ortiz, Maria P, Bottova, Iveta, Abu-Bakar, Nurhidanatasha, Kenny, Shannon, Rosenthal, Philip J, Tilley, Leann

“…Combination regimens that include artemisinin derivatives are recommended as first line antimalarials in most countries where malaria is endemic. However, the…”
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A thiol probe for measuring unfolded protein load and proteostasis in cells by Chen, Moore Z., Moily, Nagaraj S., Bridgford, Jessica L., Wood, Rebecca J., Radwan, Mona, Smith, Trevor A., Song, Zhegang, Tang, Ben Zhong, Tilley, Leann, Xu, Xiaohong, Reid, Gavin E., Pouladi, Mahmoud A., Hong, Yuning, Hatters, Danny M.

“…When proteostasis becomes unbalanced, unfolded proteins can accumulate and aggregate. Here we report that the dye, tetraphenylethene maleimide (TPE-MI) can be…”
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Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance by Yang, Tuo, Yeoh, Lee M., Tutor, Madel V., Dixon, Matthew W., McMillan, Paul J., Xie, Stanley C., Bridgford, Jessica L., Gillett, David L., Duffy, Michael F., Ralph, Stuart A., McConville, Malcolm J., Tilley, Leann, Cobbold, Simon A.

“…Increased tolerance of Plasmodium falciparum to front-line artemisinin antimalarials (ARTs) is associated with mutations in Kelch13 (K13), although the precise…”
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Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance by Dogovski, Con, Xie, Stanley C, Burgio, Gaetan, Bridgford, Jess, Mok, Sachel, McCaw, James M, Chotivanich, Kesinee, Kenny, Shannon, Gnädig, Nina, Straimer, Judith, Bozdech, Zbynek, Fidock, David A, Simpson, Julie A, Dondorp, Arjen M, Foote, Simon, Klonis, Nectarios, Tilley, Leann

“…Successful control of falciparum malaria depends greatly on treatment with artemisinin combination therapies. Thus, reports that resistance to artemisinins…”
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Deletion of the Plasmodium falciparum exported protein PTP7 leads to Maurer’s clefts vesiculation, host cell remodeling defects, and loss of surface presentation of EMP1 by Carmo, Olivia M. S, Shami, Gerald J, Cox, Dezerae, Liu, Boyin, Blanch, Adam J, Tiash, Snigdha, Tilley, Leann, Dixon, Matthew W. A

“…Presentation of the variant antigen, Plasmodium falciparum erythrocyte membrane protein 1 (EMP1), at knob-like protrusions on the surface of infected red blood…”
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Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking by Kennedy, Kit, Cobbold, Simon A, Hanssen, Eric, Birnbaum, Jakob, Spillman, Natalie J, McHugh, Emma, Brown, Hannah, Tilley, Leann, Spielmann, Tobias, McConville, Malcolm J, Ralph, Stuart A

“…Apicomplexan parasites possess a plastid organelle called the apicoplast. Inhibitors that selectively target apicoplast housekeeping functions, including DNA…”
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Altered temporal response of malaria parasites determines differential sensitivity to artemisinin by Klonis, Nectarios, Xie, Stanley C., McCaw, James M., Crespo-Ortiz, Maria P., Zaloumis, Sophie G., Simpson, Julie A., Tilley, Leann

“…Reports of emerging resistance to first-line artemisinin antimalarials make it critical to define resistance mechanisms and identify in vitro correlates of…”
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Multiple stiffening effects of nanoscale knobs on human red blood cells infected with Plasmodium falciparum malaria parasite by Zhang, Yao, Huang, Changjin, Kim, Sangtae, Golkaram, Mahdi, Dixon, Matthew W A, Tilley, Leann, Li, Ju, Zhang, Sulin, Suresh, Subra

“…Significance Our coarse-grained molecular dynamics (CGMD) simulations show that the deposition of nanoscale knobs, rather than spectrin network remodeling, is…”
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Repurposing the mitotic machinery to drive cellular elongation and chromatin reorganisation in Plasmodium falciparum gametocytes by Li, Jiahong, Shami, Gerald J., Cho, Ellie, Liu, Boyin, Hanssen, Eric, Dixon, Matthew W. A., Tilley, Leann

“…The sexual stage gametocytes of the malaria parasite, Plasmodium falciparum , adopt a falciform (crescent) shape driven by the assembly of a network of…”
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Digestive-vacuole genesis and endocytic processes in the early intraerythrocytic stages of Plasmodium falciparum by Bakar, Nurhidanatasha Abu, Klonis, Nectarios, Hanssen, Eric, Chan, Cherrine, Tilley, Leann

“…The digestive vacuole of the malaria parasite Plasmodium falciparum is the site of haemoglobin digestion and haem detoxification, and is the target of…”
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Disruption of Plasmodium falciparum kinetochore proteins destabilises the nexus between the centrosome equivalent and the mitotic apparatus by Li, Jiahong, Shami, Gerald J., Liffner, Benjamin, Cho, Ellie, Braet, Filip, Duraisingh, Manoj T., Absalon, Sabrina, Dixon, Matthew W. A., Tilley, Leann

“…Plasmodium falciparum is the causative agent of malaria and remains a pathogen of global importance. Asexual blood stage replication, via a process called…”
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Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development by Parkyn Schneider, Molly, Liu, Boyin, Glock, Philipp, Suttie, Annika, McHugh, Emma, Andrew, Dean, Batinovic, Steven, Williamson, Nicholas, Hanssen, Eric, McMillan, Paul, Hliscs, Marion, Tilley, Leann, Dixon, Matthew W A

“…Transmission of malaria parasites relies on the formation of a specialized blood form called the gametocyte. Gametocytes of the human pathogen, Plasmodium…”
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Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum by MacRae, James I, Dixon, Matthew Wa, Dearnley, Megan K, Chua, Hwa H, Chambers, Jennifer M, Kenny, Shannon, Bottova, Iveta, Tilley, Leann, McConville, Malcolm J

“…The carbon metabolism of the blood stages of Plasmodium falciparum, comprising rapidly dividing asexual stages and non-dividing gametocytes, is thought to be…”
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Reversible host cell remodeling underpins deformability changes in malaria parasite sexual blood stages by Dearnley, Megan, Chu, Trang, Zhang, Yao, Looker, Oliver, Huang, Changjin, Klonis, Nectarios, Yeoman, Jeff, Kenny, Shannon, Arora, Mohit, Osborne, James M., Chandramohanadas, Rajesh, Zhang, Sulin, Dixon, Matthew W. A., Tilley, Leann

“…The sexual blood stage of the human malaria parasite Plasmodium falciparum undergoes remarkable biophysical changes as it prepares for transmission to…”
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