Search Results - "Tilley, Douglas G"

The Role of Leukocytes in Diabetic Cardiomyopathy by Bajpai, Anamika, Tilley, Douglas G

“…Diabetes is predominant risk factor for cardiovascular diseases such as myocardial infarction and heart failure. Recently, leukocytes, particularly…”
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Early hyperlipidemia promotes endothelial activation via a caspase-1-sirtuin 1 pathway by Yin, Ying, Li, Xinyuan, Sha, Xiaojin, Xi, Hang, Li, Ya-Feng, Shao, Ying, Mai, Jietang, Virtue, Anthony, Lopez-Pastrana, Jahaira, Meng, Shu, Tilley, Douglas G, Monroy, M Alexandra, Choi, Eric T, Thomas, Craig J, Jiang, Xiaohua, Wang, Hong, Yang, Xiao-Feng

“…The role of receptors for endogenous metabolic danger signals-associated molecular patterns has been characterized recently as bridging innate immune sensory…”
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Loss of cardiomyocyte-specific adhesion G-protein-coupled receptor G1 (ADGRG1/GPR56) promotes pressure overload-induced heart failure by Einspahr, Jeanette, Xu, Heli, Roy, Rajika, Dietz, Nikki, Melchior, Jacob, Raja, Jhansi, Carter, Rhonda, Piao, Xianhua, Tilley, Douglas G

“…Adhesion G-protein-coupled receptors (AGPCRs), containing large N-terminal ligand-binding domains for environmental mechano-sensing, have been increasingly…”
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G protein-coupled receptor kinase 5 (GRK5) contributes to impaired cardiac function and immune cell recruitment in post-ischemic heart failure by de Lucia, Claudio, Grisanti, Laurel A, Borghetti, Giulia, Piedepalumbo, Michela, Ibetti, Jessica, Lucchese, Anna Maria, Barr, Eric W, Roy, Rajika, Okyere, Ama Dedo, Murphy, Haley Christine, Gao, Erhe, Rengo, Giuseppe, Houser, Steven R, Tilley, Douglas G, Koch, Walter J

“…Abstract Aims  Myocardial infarction (MI) is the most common cause of heart failure (HF) worldwide. G protein-coupled receptor kinase 5 (GRK5) is upregulated…”
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Role of Epidermal Growth Factor Receptor and Endoplasmic Reticulum Stress in Vascular Remodeling Induced by Angiotensin II by Takayanagi, Takehiko, Kawai, Tatsuo, Forrester, Steven J, Obama, Takashi, Tsuji, Toshiyuki, Fukuda, Yamato, Elliott, Katherine J, Tilley, Douglas G, Davisson, Robin L, Park, Joon-Young, Eguchi, Satoru

“…The mechanisms by which angiotensin II (AngII) elevates blood pressure and enhances end-organ damage seem to be distinct. However, the signal transduction…”
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Myeloid cell-specific deletion of epidermal growth factor receptor aggravates acute cardiac injury by Okyere, Ama D, Nayak, Tapas K, Patwa, Viren, Teplitsky, David, McEachern, Erin, Carter, Rhonda L, Xu, Heli, Gao, Erhe, Zhou, Yan, Tilley, Douglas G

“…Myeloid cells, including macrophages, play important roles as first responders to cardiac injury and stress. Epidermal growth factor receptor (EGFR) has been…”
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Dual inhibition of cathepsin G and chymase reduces myocyte death and improves cardiac remodeling after myocardial ischemia reperfusion injury by Hooshdaran, Bahman, Kolpakov, Mikhail A., Guo, Xinji, Miller, Sonni A., Wang, Tao, Tilley, Douglas G., Rafiq, Khadija, Sabri, Abdelkarim

“…Early reperfusion of ischemic cardiac tissue increases inflammatory cell infiltration which contributes to cardiomyocyte death and loss of cardiac function,…”
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β-Blockers alprenolol and carvedilol stimulate β-arrestin-mediated EGFR transactivation by Kim, Il-Man, Tilley, Douglas G, Chen, Juhsien, Salazar, Natasha C, Whalen, Erin J, Violin, Jonathan D, Rockman, Howard A

“…Recent evidence suggests that binding of agonist to its cognate receptor initiates not only classical G protein-mediated signaling, but also…”
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Cardiac GPCR-mediated EGFR transactivation: impact and therapeutic implications by Grisanti, Laurel A, Guo, Shuchi, Tilley, Douglas G

“…ABSTRACTG protein-coupled receptors (GPCR) remain primary therapeutic targets for numerous cardiovascular disorders, including heart failure (HF), due to their…”
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Leukocyte-Expressed β2-Adrenergic Receptors Are Essential for Survival After Acute Myocardial Injury by Grisanti, Laurel A, Gumpert, Anna M, Traynham, Christopher J, Gorsky, Joshua E, Repas, Ashley A, Gao, Erhe, Carter, Rhonda L, Yu, Daohai, Calvert, John W, García, Andrés Pun, Ibáñez, Borja, Rabinowitz, Joseph E, Koch, Walter J, Tilley, Douglas G

“…BACKGROUND:Immune cell–mediated inflammation is an essential process for mounting a repair response after myocardial infarction (MI). The sympathetic nervous…”
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GRK5-Mediated Exacerbation of Pathological Cardiac Hypertrophy Involves Facilitation of Nuclear NFAT Activity by Hullmann, Jonathan E, Grisanti, Laurel A, Makarewich, Catherine A, Gao, Erhe, Gold, Jessica I, Chuprun, J Kurt, Tilley, Douglas G, Houser, Steven R, Koch, Walter J

“…RATIONALE:G protein–coupled receptor kinases (GRKs) acting in the cardiomyocyte regulate important signaling events that control cardiac function. Both GRK2…”
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DUSPs as critical regulators of cardiac hypertrophy by Tilley, Douglas G, Sabri, Abdelkarim

“…This commentary highlights the research presented by Li et al. [15]. In this issue of Clinical Science, which demonstrates that dual specific phosphatase 12…”
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The Lysophosphatidylinositol Receptor GPR55 Modulates Pain Perception in the Periaqueductal Gray by Deliu, Elena, Sperow, Margaret, Console-Bram, Linda, Carter, Rhonda L, Tilley, Douglas G, Kalamarides, Daniel J, Kirby, Lynn G, Brailoiu, G Cristina, Brailoiu, Eugen, Benamar, Khalid, Abood, Mary E

“…Emerging evidence indicates the involvement of GPR55 and its proposed endogenous ligand, lysophosphatidylinositol (LPI), in nociception, yet their role in…”
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BAG3: a new player in the heart failure paradigm by Knezevic, Tijana, Myers, Valerie D., Gordon, Jennifer, Tilley, Douglas G., Sharp, Thomas E., Wang, JuFang, Khalili, Kamel, Cheung, Joseph Y., Feldman, Arthur M.

“…BAG3 is a cellular protein that is expressed predominantly in skeletal and cardiac muscle but can also be found in the brain and in the peripheral nervous…”
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Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process by Gold, Jessica I, Martini, Jeffrey S, Hullmann, Jonathan, Gao, Erhe, Chuprun, J Kurt, Lee, Linda, Tilley, Douglas G, Rabinowitz, Joseph E, Bossuyt, Julie, Bers, Donald M, Koch, Walter J

“…G protein-Coupled Receptors (GPCRs) kinases (GRKs) play a crucial role in regulating cardiac hypertrophy. Recent data from our lab has shown that, following…”
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Orphan Nuclear Receptor Nur77 Inhibits Cardiac Hypertrophic Response to Beta-Adrenergic Stimulation by Yan, Guijun, Zhu, Ni, Huang, Shengdong, Yi, Bing, Shang, Xiying, Chen, Ming, Wang, Nadan, Zhang, Guan-xin, Talarico, Jennifer A., Tilley, Douglas G., Gao, Erhe, Sun, Jianxin

“…The orphan nuclear receptor Nur77 plays critical roles in cardiovascular diseases, and its expression is markedly induced in the heart after beta-adrenergic…”
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Leukocyte-Dependent Regulation of Cardiac Fibrosis by Okyere, Ama Dedo, Tilley, Douglas G

“…Cardiac fibrosis begins as an intrinsic response to injury or ageing that functions to preserve the tissue from further damage. Fibrosis results from activated…”
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Skeletal Muscle-specific G Protein-coupled Receptor Kinase 2 Ablation Alters Isolated Skeletal Muscle Mechanics and Enhances Clenbuterol-stimulated Hypertrophy by Woodall, Benjamin P, Woodall, Meryl C, Luongo, Timothy S, Grisanti, Laurel A, Tilley, Douglas G, Elrod, John W, Koch, Walter J

“…GRK2, a G protein-coupled receptor kinase, plays a critical role in cardiac physiology. Adrenergic receptors are the primary target for GRK2 activity in the…”
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G Protein–Dependent and G Protein–Independent Signaling Pathways and Their Impact on Cardiac Function by Tilley, Douglas G

“…G protein-coupled receptors signal through a variety of mechanisms that impact cardiac function, including contractility and hypertrophy. G protein–dependent…”
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Increased Vasopressin 1A Receptor Expression in Failing Human Hearts by Zhu, Weizhong, MD, PhD, Tilley, Douglas G., PhD, Myers, Valerie D, Tsai, Emily J., MD, Feldman, Arthur M., MD, PhD

“…[...]little is known about the regulation of the V1A-R in the failing heart. [...]the present study was undertaken to evaluate the expression of the V1A-R in…”
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