Search Results - "Tillement, J"

Nicotine protects rat brain mitochondria against experimental injuries by Cormier, A, Morin, C, Zini, R, Tillement, J.-P, Lagrue, G

“…Epidemiological studies have reported that cigarette smoking may protect from neurodegenerative diseases such as Parkinson’s disease. These protective effects…”
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Systemic antifungal agents : Drug interactions of clinical significance by ALBENGRES, E, LE LOUËT, H, TILLEMENT, J.-P

“…There are 3 main classes of systemic antifungals: the polyene macrolides (e.g. amphotericin B), the azoles (e.g. the imidazoles ketoconazole and miconazole and…”
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Dehydroepiandrosterone and α-estradiol limit the functional alterations of rat brain mitochondria submitted to different experimental stresses by Morin, C, Zini, R, Simon, N, Tillement, J.P

“…The effects of dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S), α-estradiol and β-estradiol on the main functions of purified rat brain…”
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Effects of resveratrol on the rat brain respiratory chain by Zini, R, Morin, C, Bertelli, A, Bertelli, A A, Tillement, J P

“…The aim of this work was to investigate the possible effects of resveratrol on the mitochondrial respiratory chain in rat brains. Isolation of mitochondria was…”
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Drug transfer across the blood-brain barrier and improvement of brain delivery by Jolliet-Riant, Pascale, Tillement, Jean-Paul

“…— The blood‐brain barrier is formed by the endothelial cells of the brain capillaries. Its primary characteristic is the impermeability of the capillary wall…”
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Curcumin induces the mitochondrial permeability transition pore mediated by membrane protein thiol oxidation by Morin, Didier, Barthélémy, Sophie, Zini, Roland, Labidalle, Serge, Tillement, Jean-Paul

“…Curcumin is a natural compound showing antiproliferative properties. Recent studies suggest that these properties might be due to its ability to induce…”
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Drug binding in plasma : a summary of recent trends in the study of drug and hormone binding by HERVE, F, URIEN, S, ALBENGRES, E, DUCHE, J.-C, TILLEMENT, J.-P

“…The ligands are generally bound in plasma to a significant extent by several transport proteins (both high and low affinity), irrespective of their endogenous…”
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Molecular Properties and Pharmacokinetic Behavior of Cetirizine, a Zwitterionic H1-Receptor Antagonist by Pagliara, Alessandra, Testa, Bernard, Carrupt, Pierre-Alain, Jolliet, Pascale, Morin, Christophe, Morin, Didier, Urien, Saïk, Tillement, Jean-Paul, Rihoux, Jean-Pierre

“…The ionization and lipophilicity behavior of the antihistamine (H1-receptor antagonist) cetirizine was investigated, showing the drug to exist almost…”
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Trimetazidine prevents renal injury in the isolated perfused pig kidney exposed to prolonged cold ischemia by HAUET, T, MOTHES, D, GOUJON, J.-M, CARITEZ, J. C, CARRETIER, M, LE MOYEC, L, EUGENE, M, TILLEMENT, J.-P

“…Ischemia caused by cold storage (CS) and reperfusion of the kidney is often responsible for delayed graft function after transplantation. Significant attention…”
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Structural damage to proteins caused by free radicals: asessment, protection by antioxidants, and influence of protein binding by Salvi, Aline, Carrupt, Pierre-Alain, Tillement, Jean-Paul, Testa, Bernard

“…Oxidative damage to proteins results in biological dysfunctions such as perturbed activity in enzymes, transport proteins, and receptors. Here, we investigated…”
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Evidence for the existence of [3H]‐trimetazidine binding sites involved in the regulation of the mitochondrial permeability transition pore by Morin, Didier, Elimadi, Aziz, Sapena, Rosa, Crevat, Aimé, Carrupt, Pierre‐Alain, Testa, Bernard, Tillement, Jean‐Paul

“…Trimetazidine is an anti‐ischaemic drug effective in different experimental models but its mechanism of action is not fully understood. Data indicate that…”
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Drug transfer across the blood-brain barrier: correlation between in vitro and in vivo models by Dehouck, M P, Jolliet-Riant, P, Brée, F, Fruchart, J C, Cecchelli, R, Tillement, J P

“…To assess the drug transport across the blood-brain barrier (BBB), we compared the maximal brain extraction values at time 0 [E(0) values] obtained using…”
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In vitro effects of nicotine on mitochondrial respiration and superoxide anion generation by Cormier, Anne, Morin, Christophe, Zini, Roland, Tillement, Jean-Paul, Lagrue, Gilbert

“…In this study, we investigated the effects of nicotine on rat brain mitochondria. The polarographic studies determined the effects on the respiratory chain,…”
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Evidence for resveratrol-induced preservation of brain mitochondria functions after hypoxia-reoxygenation by Morin, C, Zini, R, Albengres, E, Bertelli, A A E, Bertelli, A, Tillement, J P

“…We have previously shown, as have other authors, that trans-resveratrol (E-resveratrol, 3,4,5-trihydroxy-E-stilbene) reduces reactive oxygen species (ROS)…”
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The advantages for an H1 antihistamine of a low volume of distribution by Tillement, J‐P.

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Plasma, urine and tissue levels of trans- and cis-resveratrol (3,4',5-trihydroxystilbene) after short-term or prolonged administration of red wine to rats by Bertelli, A A, Giovannini, L, Stradi, R, Bertelli, A, Tillement, J P

“…The aim of the present study was to evaluate the absorption, the concentration in different organs and the excretion of natural trans- and cis-resveratrol…”
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Mitochondria as target for antiischemic drugs by Morin, Didier, Hauet, Thierry, Spedding, Michael, Tillement, Jean-Paul

“…The cessation of blood flow followed by a reperfusion period results in severe damages to cell structures. This induces a complex cascade of events involving,…”
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[3H]‐Trimetazidine mitochondrial binding sites: regulation by cations, effect of trimetazidine derivatives and other agents and interaction with an endogenous substance by Morin, Didier, Sapena, Rosa, Elimadi, Aziz, Testa, Bernard, Labidalle, Serge, Le Ridant, Alain, Tillement, Jean‐Paul

“…Trimetazidine, an antiischaemic drug, has been shown to restore impaired mitochondrial functions. Specific binding sites for [3H]‐trimetazidine have been…”
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Trimetazidine reverses calcium accumulation and impairment of phosphorylation induced by cyclosporine A in isolated rat liver mitochondria by Salducci, M D, Chauvet-Monges, A M, Tillement, J P, Albengres, E, Testa, B, Carrupt, P, Crevat, A

“…When applied to rat liver mitochondria in contact with Ca++, cyclosporine A (CsA) induced both an accumulation of this ion and a decrease in oxidative…”
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Attenuation of liver normothermic ischemia-reperfusion injury by preservation of mitochondrial functions with S-15176, a potent trimetazidine derivative by Elimadi, Aziz, Sapena, Rosa, Settaf, Abdellatif, Le Louet, Herve, Tillement, Jean-Paul, Morin, Didier

“…We investigated the antiischemic properties of a new compound, S-15176, in an experimental model of rat liver subjected to 120-min normothermic ischemia…”
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