Search Results - "Tilleman, L."
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Direct comparison of distinct naive pluripotent states in human embryonic stem cells
Published in Nature communications (21-04-2017)“…Until recently, human embryonic stem cells (hESCs) were shown to exist in a state of primed pluripotency, while mouse embryonic stem cells (mESCs) display a…”
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Exposure–response relationship of guselkumab and the potential of serum proteomics in identifying predictive biomarker candidates in psoriasis
Published in Journal of the European Academy of Dermatology and Venereology (01-08-2024)“…Background Response to biologics in psoriasis varies in real‐world settings. Serum biomarkers could aid biologic selection and dose modifications to improve…”
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Comparative study of preimplantation development following distinct assisted oocyte activation protocols in a PLC-zeta knockout mouse model
Published in Molecular human reproduction (01-11-2020)“…Abstract Mammalian fertilization encompasses a series of Ca2+ oscillations initiated by the sperm factor phospholipase C zeta (PLCζ). Some studies have shown…”
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Gain of 20q11.21 in Human Pluripotent Stem Cells Impairs TGF-β-Dependent Neuroectodermal Commitment
Published in Stem cell reports (09-07-2019)“…Gain of 20q11.21 is one of the most common recurrent genomic aberrations in human pluripotent stem cells. Although it is known that overexpression of the…”
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Transcriptional landscape changes during human embryonic stem cell derivation
Published in Molecular human reproduction (01-11-2018)“…What are the transcriptional changes occurring during the human embryonic stem cell (hESC) derivation process, from the inner cell mass (ICM) to post-ICM…”
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The transcription factor ETS1 is an important regulator of human NK cell development and terminal differentiation
Published in Blood (16-07-2020)“…Natural killer (NK) cells are important in the immune defense against tumor cells and pathogens, and they regulate other immune cells by cytokine secretion…”
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PS1233 HES1 AND HES4 HAVE SIMILAR AND DIVERSE CAPACITIES TO MEDIATE HUMAN NOTCH‐DEPENDENT HEMATOPOIETIC LINEAGE DECISIONS
Published in HemaSphere (01-06-2019)“…Background: Multipotent hematopoietic stem cells (HSCs) originate in the bone marrow and give rise to all the different cell types in the blood. This process…”
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