Search Results - "Tilby, M.J"

Nematode ageing. Automatic maintenance of age synchrony without inhibitors by Tilby, M J, Moses, V

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Decreased telomerase activity is not a reliable indicator of chemosensitivity in testicular cancer cell lines by Cressey, T.R, Tilby, M.J, Newell, D.R

“…Telomere stabilisation is a critical step in tumorigenesis and telomerase, an enzyme which counteracts telomeric DNA loss, is active in most tumours…”
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Mechanisms of action of, and modes of resistance to, alkylating agents used in the treatment of haematological malignancies by Hall, A G, Tilby, M J

“…Although the alkylating agents were amongst the first non-hormonal compounds to be shown to be active against malignant cells they still rank as some of the…”
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Cisplatin pharmacokinetics in children with cancer by Peng, B., English, M.W., Boddy, A.V., Price, L., Wyllie, R., Pearson, A.D.J., Tilby, M.J., Newell, D.R.

“…Cisplatin is an important drug in the treatment of a number of paediatric cancers yet, despite wide-spread use, there are only very limited data on the…”
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Pharmacokinetically guided dose escalation of carboplatin in epithelial ovarian cancer: Effect on drug-plasma AUC and peripheral blood drug-DNA adduct levels by Ghazal-Aswad, S., Tilby, M.J., Lind, M., Baily, N., Sinha, D. P., Calvert, A. H., Newell, D. R.

“…Background: Platinum based drugs are active agents in epithelial ovarian cancer and increased platinum drug dose intensity is thought to lead to improved…”
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Inhibition of Coprinus civereus by 5-fluoroindole by Tilby M.J

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Application of a sensitive immunoassay to the study of DNA adducts formed in peripheral blood mononuclear cells of patients undergoing high-dose melphalan therapy by Tilby, M J, Newell, D R, Viner, C, Selby, P J, Dean, C J

“…The levels of DNA adducts formed in peripheral blood mononuclear cells of 13 patients undergoing high-dose melphalan therapy were determined 0-24 h after drug…”
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Alkylation of DNA by melphalan in relation to immunoassay of melphalan-DNA adducts: characterization of mono-alkylated and cross-linked products from reaction of melphalan with dGMP and GMP by Tilby, M J, Lawley, P D, Farmer, P B

“…A product expected to result from cross-linking of guanine bases in DNA by melphalan (4-(2-(di-guanin-7-yl))ethylamino-L-phenylalanine) was obtained from…”
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Inhibition of Coprinus cinereus by 5 fluoroindole by Tilby, M.J

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An Effect of Elevated Postirradiation pH on the Yield of Double-Strand Breaks in DNA from Irradiated Bacterial Cells by Tilby, Michael J., Loverock, Pamela S., Fielden, E. Martin

“…Exposure of DNA isolated from irradiated cells of Escherichia coli to a pH of 9.6 caused a marked increase in the yield of double-strand breaks (dsb). The dsb…”
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Measurements of DNA Double-Strand Break Yields in E. coli after Rapid Irradiation and Cell Inactivation: The Effects of Inactivation Technique and Anoxic Radiosensitizers by Tilby, Michael J., Loverock, Pamela S.

“…A study has been made of methods for rapidly inactivating cells of E. coli at neutral pH to prevent enzymatic, chemical, or physical modification to DNA…”
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Tryptophan biosynthesis in Coprinus lagopus: a genetic analysis of mutants by Tilby, M.J

“…Department of Plant Biology and Microbiology, Queen Mary College, University of London, London E1 4NS ABSTRACT SUMMARY: Thirty-one tryptophan-requiring mutants…”
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