Search Results - "Tikhonova, M A"

Effect of Trehalose Disaccharide on Activation of Microglia and Indices of Systemic Inflammation in an Experimental Model of Alzheimer’s Disease by Zozulya, S. A., Akopyan, A. A., Tenditnik, M. V., Ovsyukova, M. V., Korolenko, T. A., Klyushnik, T. P., Tikhonova, M. A., Pupyshev, A. B.

“…In an experimental model of Alzheimer’s disease in mice, oral administration of trehalose disaccharide reduces neuroinflammation assessed by the expression…”
Get full text

Angiogenin as a Possible Mediator of Macrophage-Mediated Regulation of Fibroblast Functions by Maksimova, A. A., Shevela, E. Ya, Tikhonova, M. A., Tyrinova, T. V., Bogachev, S. S., Ostanin, A. A., Chernykh, E. R.

“…We studied angiogenin production by human macrophages and evaluated the role of this factor in the macrophage-mediated regulation of fibroblasts. All…”
Get full text

Restoration of Parkinson’s Disease-Like Deficits by Activating Autophagy through mTOR-Dependent and mTOR-Independent Mechanisms in Pharmacological and Transgenic Models of Parkinson’s Disease in Mice by Pupyshev, A. B., Tenditnik, M. V., Ovsyukova, M. V., Akopyan, A. A., Dubrovina, N. I., Tikhonova, M. A.

“…We studied the possibilities of inhibition of neurodegeneration in MPTP-induced model of Parkinson’s disease (PD) in C57Bl/6J mice and transgenic model of…”
Get full text

Content of Peripheral Blood T- and B-Cell Subpopulations in Transgenic A53T Mice of Different Age (A Model of Parkinson’s Disease) by Idova, G. V., Al’perina, E. L., Gevorgyan, M. M., Tikhonova, M. A., Zhanaeva, S. Ya

“…We analyzed the behavior and peripheral blood T- and B-cell subpopulations in mice overexpressing the mutant form of human α-synuclein (A53T) in comparison…”
Get full text

Efferocytosis Modulates Arginase-1 and Tyrosine Kinase Mer Expression in GM-CSF-Differentiated Human Macrophages by Sakhno, L. V., Shevela, E. Ya, Tikhonova, M. A., Maksimova, A. A., Tyrinova, T. V., Ostanin, A. A., Chernykh, E. R.

“…We studied the expression of arginase-1 (Arg1) and tyrosine kinase Mer (MerTK) in GMCSF-differentiated human macrophage populations М0, М1(IFNγ), М2а(IL-4),…”
Get full text

Influence of Secretome of Different Functional Phenotypes of Macrophages on Proliferation, Differentiation, and Collagen-Producing Activity of Dermal Fibroblasts In Vitro by Maksimova, A. A., Shevela, E. Ya, Sakhno, L. V., Tikhonova, M. A., Ostanin, A. A., Chernykh, E. R.

“…We studied the effect of conditioned media of GM-CSF-differentiated human macrophages polarized in M1(LPS), M2a(IL-4), M2c(dexamethasone), and M2(low serum)…”
Get full text

Effect of Antidepressants on Immunological Reactivity in ASC Mice with Genetically Determined Depression-Like State by Gevorgyan, M. M., Idova, G. V., Al’perina, E. L., Tikhonova, M. A., Kulikov, A. V.

“…The effect of chronic treatment with antidepressant drugs fluoxetine (20 mg/kg) and imipramine (25 mg/kg) on the number of antibody-producing cells and the…”
Get full text

CCL19/CCL21-Dependent Chemotaxis of Dendritic Cells in Healthy Individuals and Patients with Brain Tumors by Tyrinova, T. V., Leplina, O. Yu, Tikhonova, M. A., Mishinov, S. V., Stupak, V. V., Ostanin, A. A., Chernykh, E. R.

“…We compared migration activities of IFN-α- and IL-4-induced dendritic cells (IFN-DC and IL4-DC) generated from blood monocytes of healthy donors and analyzed…”
Get full text

Fear Memory in Experimental Models of Parkinson’s Disease by Timofeeva, E. A., Dubrovina, N. I., Tikhonova, M. A., Amstislavskaya, T. G.

“…Parkinson’s disease (PD) is a neurodegenerative disease, the main predisposing factor of which is aging. Today, the majority of people suffering from PD are…”
Get full text

Effects of Stress on Corticosterone Levels, Expression of the c-fos Gene, and Serotonin Metabolism in the Brains of Mice with a Genetic Predisposition to Catalepsy by Bazhenova, E. Yu, Kulikov, A. V., Tikhonova, M. A., Tsybko, A. S., Popova, N. K.

“…Freezing reactions, or catalepsy, constitute a passive defensive reaction to stress. The involvement of brain serotonin (5-HT) in the regulation of catalepsy…”
Get full text

Application of autologous bone marrow stem cells in the therapy of spinal cord injury patients by Chernykh, E R, Stupak, V V, Muradov, G M, Sizikov, M Yu, Shevela, E Ya, Leplina, O Yu, Tikhonova, M A, Kulagin, A D, Lisukov, I A, Ostanin, A A, Kozlov, V A

“…We studied the safety and efficiency of transplantation of autologous bone marrow cells in complex therapy of patients with spinal cord injury in the late…”
Get full text

The Phenotypic and Functional Features of Human M2 Macrophages Generated Under Low Serum Conditions by Sakhno, L. V., Shevela, E. Ya, Tikhonova, M. A., Ostanin, A. A., Chernykh, E. R.

“…The phenotypic and functional features of human M2 macrophages, in particular, their immunosuppressive activity, can considerably vary depending on M2…”
Get full text

Effect of brain-derived neurotrophic factor on behavior and key members of the brain serotonin system in genetically predisposed to behavioral disorders mouse strains by Naumenko, V.S, Kondaurova, E.M, Bazovkina, D.V, Tsybko, A.S, Tikhonova, M.A, Kulikov, A.V, Popova, N.K

“…Highlights ► Central BDNF administration produced ameliorative effect on depressive-like behavior. ► Long-term BDNF effect on “depressive” ASC mice involves…”
Get full text

Intracerebral Administration of Brain-Derived Neurotrophic Factor (BDNF) Reduces Severity of Cataleptic Freezing in Mice with Genetic Predisposition to Catalepsy by Tikhonova, M. A, Kulikov, A. V, Naumenko, V. S, Morozova, M. V, Bazovkina, D. V, Popova, N. K

“…Single administration of brain-derived neurotrophic factor (BDNF) into the lateral ventricle of ASC mice (Antidepressant Sensitive Catalepsy), a model of…”
Get full text

Expression of arginase 1 and tyrosine kinase Mer by blood monocytes in the dynamics of physiological pregnancy by Shevela, E. Ya, Bukhtueva, N. G., Tikhonova, M. A., Sakhno, L. V., Pasman, N. M., Chernykh, E. R.

“…During pregnancy, the maternal immune system must maintain tolerance to paternal antigens, at the same time being able to eliminate pathogens, which is…”
Get full text

Allostimulatory activity as a criterion of the functional phenotype of human macrophages by Yankovskaya, A.A., Shevela, E.Y., Sakhno, L.V., Tikhonova, M.A., Dome, A.S., Ostanin, A.A., Chernykh, E.R.

“…The functional phenotype of macrophages (Mφ) is determined by both differentiation factors and polarization stimuli. In mouse Mφ could be easily divided into…”
Get full text

Myeloid-derived suppressor cells in axial spondyloarthritis patients with different types of therapy by Morenkova, A. Yu, Tyrinova, T. V., Fedorova, A. V., Tikhonova, M. A., Ilina, N. A., Chumasova, O. A., Sizikov, A. E., Chernykh, E. R.

“…Aim – to evaluate myeloid-derived suppressor cell (MDSC) subset counts and their suppressor potential in axial spondyloarthritis (axSpA) patients, as well as…”
Get full text

Effect of Dehydroepiandrosterone Sulfate on Maturation and Functional Properties of Interferon-α-Induced Dendritic Cells by Leplina, O. Yu, Tikhonova, M. A, Sakchno, L. V, Tyrinova, T. V, Ostanin, A. A, Chernykh, E. R

“…We studied the effect of adrenal cortex hormone dehydroepiandrosterone sulfate on maturation and functional activity of interferon-α-induced dendritic cells…”
Get full text

Expression of M2-associated molecules in circulating monocyte subsets in fertile non-pregnant women and pregnant women with uncomplicated pregnancy by Shevela, E. Ya, Bukhtueva, N. G., Tikhonova, M. A., Leplina, O. Yu, Pasman, N. M., Chernykh, E. R.

“…In humans circulating monocytes include classical (CD14 ++ CD16 - ), intermediate (CD14 ++ CD16 + ) and non-classical/alternative (CD14 + CD16 ++ ) monocytes,…”
Get full text

M-CSF and GM-CSF determinate fibromodulatory activity of polarized human macrophages by Maksimova, A. A., Shevela, E. Ya, Sakhno, L. V., Tikhonova, M. A., Ostanin, A. A., Chernykh, E. R.

“…GM-CSF and M-CSF, the hematopoietic colony-stimulating factors, induce various phenotypic changes in macrophage lineage populations and promote cell…”
Get full text