Search Results - "Tikhonova, Anastasia N."

The bone marrow microenvironment at single-cell resolution by Tikhonova, Anastasia N., Dolgalev, Igor, Hu, Hai, Sivaraj, Kishor K., Hoxha, Edlira, Cuesta-Domínguez, Álvaro, Pinho, Sandra, Akhmetzyanova, Ilseyar, Gao, Jie, Witkowski, Matthew, Guillamot, Maria, Gutkin, Michael C., Zhang, Yutong, Marier, Christian, Diefenbach, Catherine, Kousteni, Stavroula, Heguy, Adriana, Zhong, Hua, Fooksman, David R., Butler, Jason M., Economides, Aris, Frenette, Paul S., Adams, Ralf H., Satija, Rahul, Tsirigos, Aristotelis, Aifantis, Iannis

“…The bone marrow microenvironment has a key role in regulating haematopoiesis, but its molecular complexity and response to stress are incompletely understood…”
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Under the surface: scratching the acute lymphoblastic leukemia niche by Gower, Mark, Tikhonova, Anastasia N

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Connecting the Dots: Resolving the Bone Marrow Niche Heterogeneity by Dolgalev, Igor, Tikhonova, Anastasia N

“…Single-cell sequencing approaches have transformed our understanding of stem cell systems, including hematopoiesis and its niche within the bone marrow. Recent…”
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CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance by Pitt, Lauren A., Tikhonova, Anastasia N., Hu, Hai, Trimarchi, Thomas, King, Bryan, Gong, Yixiao, Sanchez-Martin, Marta, Tsirigos, Aris, Littman, Dan R., Ferrando, Adolfo A., Morrison, Sean J., Fooksman, David R., Aifantis, Iannis, Schwab, Susan R.

“…The role of the microenvironment in T cell acute lymphoblastic leukemia (T-ALL), or any acute leukemia, is poorly understood. Here we demonstrate that T-ALL…”
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Interleukin-17 governs hypoxic adaptation of injured epithelium by Konieczny, Piotr, Xing, Yue, Sidhu, Ikjot, Subudhi, Ipsita, Mansfield, Kody P, Hsieh, Brandon, Biancur, Douglas E, Larsen, Samantha B, Cammer, Michael, Li, Dongqing, Landén, Ning Xu, Loomis, Cynthia, Heguy, Adriana, Tikhonova, Anastasia N, Tsirigos, Aristotelis, Naik, Shruti

“…Mammalian cells autonomously activate hypoxia-inducible transcription factors (HIFs) to ensure survival in low-oxygen environments. We report here that…”
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Lck Availability during Thymic Selection Determines the Recognition Specificity of the T Cell Repertoire by Van Laethem, François, Tikhonova, Anastasia N., Pobezinsky, Leonid A., Tai, Xuguang, Kimura, Motoko Y., Le Saout, Cécile, Guinter, Terry I., Adams, Anthony, Sharrow, Susan O., Bernhardt, Günter, Feigenbaum, Lionel, Singer, Alfred

“…Thymic selection requires signaling by the protein tyrosine kinase Lck to generate T cells expressing αβ T cell antigen receptors (TCR). For reasons not…”
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αβ T Cell Receptors that Do Not Undergo Major Histocompatibility Complex-Specific Thymic Selection Possess Antibody-like Recognition Specificities by Tikhonova, Anastasia N., Van Laethem, François, Hanada, Ken-ichi, Lu, Jinghua, Pobezinsky, Leonid A., Hong, Changwan, Guinter, Terry I., Jeurling, Susanna K., Bernhardt, Günter, Park, Jung-Hyun, Yang, James C., Sun, Peter D., Singer, Alfred

“…Major histocompatibility complex (MHC) restriction is the cardinal feature of T cell antigen recognition and is thought to be intrinsic to αβ T cell receptor…”
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Avoiding fratricide: a T-ALL order by Gower, Mark, Tikhonova, Anastasia N

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Stem cells pack some chillis for the road by Tikhonova, Anastasia N, Aifantis, Iannis

“…Since the 1990s, a secreted factor known as granulocyte-colony-stimulating factor (G-CSF) has been the most commonly used molecular prompt. [...]questions can…”
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Pain-sensing neurons mobilize blood stem cells from bone marrow by Tikhonova, Anastasia N., Aifantis, Iannis

“…Pain-sensing nerve cells can mobilize blood stem cells in mice, with a component of chilli peppers being one stimulus. The finding holds the promise of…”
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There won’T be blood by Gower, Mark, Foster, Gena, Tikhonova, Anastasia N.

“…Riok2 haploinsufficiency leads to aberrant T H 22 skewing and interleukin-22-mediated erythroid dysfunction…”
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Cell-by-Cell Deconstruction of Stem Cell Niches by Tikhonova, Anastasia N., Lasry, Audrey, Austin, Rebecca, Aifantis, Iannis

“…Single-cell sequencing approaches offer exploration of tissue architecture at unprecedented resolution. These tools are especially powerful when deconvoluting…”
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Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia by Witkowski, Matthew T., Dolgalev, Igor, Evensen, Nikki A., Ma, Chao, Chambers, Tiffany, Roberts, Kathryn G., Sreeram, Sheetal, Dai, Yuling, Tikhonova, Anastasia N., Lasry, Audrey, Qu, Chunxu, Pei, Deqing, Cheng, Cheng, Robbins, Gabriel A., Pierro, Joanna, Selvaraj, Shanmugapriya, Mezzano, Valeria, Daves, Marla, Lupo, Philip J., Scheurer, Michael E., Loomis, Cynthia A., Mullighan, Charles G., Chen, Weiqiang, Rabin, Karen R., Tsirigos, Aristotelis, Carroll, William L., Aifantis, Iannis

“…A subset of B cell acute lymphoblastic leukemia (B-ALL) patients will relapse and succumb to therapy-resistant disease. The bone marrow microenvironment may…”
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Treatment response in acute myeloid leukaemia—Clues in the biopsy core by Aguilar Navarro, Alicia G., Tikhonova, Anastasia N.

“…In their paper the authors describe distinct transcriptomic changes associated to treatment response in core bone marrow biopsies from patients with acute…”
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MHC restriction is imposed on a diverse T cell receptor repertoire by CD4 and CD8 co-receptors during thymic selection by Van Laethem, François, Tikhonova, Anastasia N, Singer, Alfred

“…Mature αβ T cells recognize foreign antigenic peptides presented by MHC molecules but do not recognize native antigenic proteins; features known as MHC…”
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Structure of MHC-Independent TCRs and Their Recognition of Native Antigen CD155 by Lu, Jinghua, Van Laethem, François, Saba, Ingrid, Chu, Jonathan, Tikhonova, Anastasia N, Bhattacharya, Abhisek, Singer, Alfred, Sun, Peter D

“…During normal T cell development in the thymus, αβ TCRs signal immature thymocytes to differentiate into mature T cells by binding to peptide-MHC ligands…”
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The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation by Guillamot, Maria, Ouazia, Dahmane, Dolgalev, Igor, Yeung, Stephen T., Kourtis, Nikos, Dai, Yuling, Corrigan, Kate, Zea-Redondo, Luna, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Tikhonova, Anastasia N., Malumbres, Marina, Gong, Yixiao, Tsirigos, Aristotelis, Park, Christopher, Barbieri, Christopher, Khanna, Kamal M., Busino, Luca, Aifantis, Iannis

“…The response to systemic infection and injury requires the rapid adaptation of hematopoietic stem cells (HSCs), which proliferate and divert their…”
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An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia by Lasry, Audrey, Nadorp, Bettina, Fornerod, Maarten, Nicolet, Deedra, Wu, Huiyun, Walker, Christopher J, Sun, Zhengxi, Witkowski, Matthew T, Tikhonova, Anastasia N, Guillamot-Ruano, Maria, Cayanan, Geraldine, Yeaton, Anna, Robbins, Gabriel, Obeng, Esther A, Tsirigos, Aristotelis, Stone, Richard M, Byrd, John C, Pounds, Stanley, Carroll, William L, Gruber, Tanja A, Eisfeld, Ann-Kathrin, Aifantis, Iannis

“…Acute myeloid leukemia (AML) is a hematopoietic malignancy with poor prognosis and limited treatment options. Here we provide a comprehensive census of the…”
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Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models by Rondeau, Vincent, Berman, Jacob M, Ling, Tianyi, O'Brien, Cristiana, Culp-Hill, Rachel, Reisz, Julie A, Wunderlich, Mark, Chueh, Yun, Jiménez-Camacho, Karina E, Sexton, Christina, Carter, Katharine M, Stillwell, Cody, St-Germain, Jonathan, Yendi, Duhan, Gupta, Aarushi, Shi, Mary, Bourdine, Aleksandra, Paralkar, Vikram R, Jahangiri, Soheil, Hope, Kristin J, Tikhonova, Anastasia N, Arruda, Andrea, Minden, Mark D, Raught, Brian, D'Alessandro, Angelo, Jones, Courtney L

“…Acute myeloid leukemia (AML) is a devastating disease initiated and maintained by a rare subset of cells called leukemia stem cells (LSCs). LSCs are…”
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Author Correction: The bone marrow microenvironment at single-cell resolution by Tikhonova, Anastasia N., Dolgalev, Igor, Hu, Hai, Sivaraj, Kishor K., Hoxha, Edlira, Cuesta-Domínguez, Álvaro, Pinho, Sandra, Akhmetzyanova, Ilseyar, Gao, Jie, Witkowski, Matthew, Guillamot, Maria, Gutkin, Michael C., Zhang, Yutong, Marier, Christian, Diefenbach, Catherine, Kousteni, Stavroula, Heguy, Adriana, Zhong, Hua, Fooksman, David R., Butler, Jason M., Economides, Aris, Frenette, Paul S., Adams, Ralf H., Satija, Rahul, Tsirigos, Aristotelis, Aifantis, Iannis

“…An Amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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