Search Results - "Tijsterman, M"

BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining by Kamp, J. A., van Schendel, R., Dilweg, I. W., Tijsterman, M.

“…Failure to preserve the integrity of the genome is a hallmark of cancer. Recent studies have revealed that loss of the capacity to repair DNA breaks via…”
Get full text

Helicase Q promotes homology-driven DNA double-strand break repair and prevents tandem duplications by Kamp, J. A., Lemmens, B. B. L. G., Romeijn, R. J., Changoer, S. C., van Schendel, R., Tijsterman, M.

“…DNA double-strand breaks are a major threat to cellular survival and genetic integrity. In addition to high fidelity repair, three intrinsically mutagenic DNA…”
Get full text

The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2α by Gort, E H, van Haaften, G, Verlaan, I, Groot, A J, Plasterk, R H A, Shvarts, A, Suijkerbuijk, K P M, van Laar, T, van der Wall, E, Raman, V, van Diest, P J, Tijsterman, M, Vooijs, M

“…Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that play a crucial role in oxygen homeostasis. Intratumoral hypoxia and genetic…”
Get full text

Dicers at RISC: The Mechanism of RNAi by Tijsterman, Marcel, Plasterk, Ronald H.A

“…The pathway of RNA interference starts when Dicer cuts dsRNA into small interfering RNAs (siRNAs) that subsequently target homologous mRNAs for destruction…”
Get full text

Transitions in the coupling of transcription and nucleotide excision repair within RNA polymerase II-transcribed genes of Saccharomyces cerevisiae by Tijsterman, M. (Leiden University, Leiden, The Netherlands.), Verhage, R.A, Putte, P. van de, Tasseron-de Jong, J.G, Brouwer, J

“…The molecular mechanism of transcription- coupled nucleotide excision repair in eukaryotes is poorly understood. The identification of the dual role of basal…”
Get full text

THO complex deficiency impairs DNA double-strand break repair via the RNA surveillance kinase SMG-1 by Kamp, Juliette A, Lemmens, Bennie B L G, Romeijn, Ron J, González-Prieto, Román, Olsen, Jesper V, Vertegaal, Alfred C O, van Schendel, Robin, Tijsterman, Marcel

“…The integrity and proper expression of genomes are safeguarded by DNA and RNA surveillance pathways. While many RNA surveillance factors have additional…”
Get full text

Mutagenic Capacity of Endogenous G4 DNA Underlies Genome Instability in FANCJ-Defective C. elegans by Kruisselbrink, Evelien, Guryev, Victor, Brouwer, Karin, Pontier, Daphne B., Cuppen, Edwin, Tijsterman, Marcel

“…To safeguard genetic integrity, cells have evolved an accurate but not failsafe mechanism of DNA replication. Not all DNA sequences tolerate DNA replication…”
Get full text

Loss of the Putative RNA-Directed RNA Polymerase RRF-3 Makes C. elegans Hypersensitive to RNAi by Simmer, Femke, Tijsterman, Marcel, Parrish, Susan, Koushika, Sandhya P, Nonet, Michael L, Fire, Andrew, Ahringer, Julie, Plasterk, Ronald H.A

“…RNA interference (RNAi) is a broadly used reverse genetics method in C. elegans [1]. Unfortunately, RNAi does not inhibit all genes [2, 3]. We show that loss…”
Get full text

Enzymatic detection of ultraviolet-induced pyrimidine (6-4) pyrimidone photoproducts at nucleotide resolution in Saccharomyces cerevisiae by Tijsterman, M, Verhoeven, E E, Jong, J G, Brouwer, J

Get full text

Mapping determinants of gene expression plasticity by genetical genomics in C. elegans by Li, Yang, Alvarez, Olga Alda, Gutteling, Evert W, Tijsterman, Marcel, Fu, Jingyuan, Riksen, Joost A G, Hazendonk, Esther, Prins, Pjotr, Plasterk, Ronald H A, Jansen, Ritsert C, Breitling, Rainer, Kammenga, Jan E

“…Recent genetical genomics studies have provided intimate views on gene regulatory networks. Gene expression variations between genetically different…”
Get full text

Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi by Pothof, Joris, van Haaften, Gijs, Thijssen, Karen, Kamath, Ravi S, Fraser, Andrew G, Ahringer, Julie, Plasterk, Ronald H A, Tijsterman, Marcel

“…An RNA interference (RNAi)-based genome-wide screen was performed to detect genes that contribute to genome stability in somatic cells of Caenorhabditis…”
Get full text

THE GENETICS OF RNA SILENCING by Tijsterman, Marcel, Ketting, René F, Plasterk, Ronald H. A

“…Although initially recognized as a handy tool to reduce gene expression, RNA silencing, triggered by double-stranded RNA molecules, is now recognized as a…”
Get full text

Genes Required for Systemic RNA Interference in Caenorhabditis elegans by Tijsterman, Marcel, May, Robin C., Simmer, Femke, Okihara, Kristy L., Plasterk, Ronald H.A.

“…RNA interference (RNAi) in the nematode worm, Caenorhabditis elegans, occurs systemically. Double-stranded RNA (dsRNA) provided in the diet can be absorbed…”
Get full text

A Caenorhabditis elegans Wild Type Defies the Temperature-Size Rule Owing to a Single Nucleotide Polymorphism in tra-3 by Kammenga, J.E, Doroszuk, A, Riksen, J.A.G, Hazendonk, E, Spiridon, L, Petrescu, A.J, Tijsterman, M, Plasterk, R.H.A, Bakker, J

“…Ectotherms rely for their body heat on surrounding temperatures. A key question in biology is why most ectotherms mature at a larger size at lower…”
Get full text

Identification of Conserved Pathways of DNA-Damage Response and Radiation Protection by Genome-Wide RNAi by van Haaften, Gijs, Romeijn, Ron, Pothof, Joris, Koole, Wouter, Mullenders, Leon H.F., Pastink, Albert, Plasterk, Ronald H.A., Tijsterman, Marcel

“…Ionizing radiation is extremely harmful for human cells, and DNA double-strand breaks (DSBs) are considered to be the main cytotoxic lesions induced [1]…”
Get full text

PPW-1, a PAZ/PIWI Protein Required for Efficient Germline RNAi, Is Defective in a Natural Isolate of C. elegans by Tijsterman, Marcel, Okihara, Kristy L, Thijssen, Karen, Plasterk, Ronald H.A

“…One of the remarkable aspects about RNA interference (RNAi) in Caenorhabditis elegans is that the trigger molecules, dsRNA, can be administered via the…”
Get full text

RNA Helicase MUT-14-Dependent Gene Silencing Triggered in C. elegans by Short Antisense RNAs by Tijsterman, Marcel, Ketting, René F., Okihara, Kristy L., Sijen, Titia, Ronald H. A. Plasterk

“…Posttranscriptional gene silencing in Caenorhabditis elegans results from exposure to double-stranded RNA (dsRNA), a phenomenon designated as RNA interference…”
Get full text

Gene Interactions in the DNA Damage-Response Pathway Identified by Genome-Wide RNA-Interference Analysis of Synthetic Lethality by van Haaften, Gijs, Vastenhouw, Nadine L., Ellen A. A. Nollen, Ronald H. A. Plasterk, Tijsterman, Marcel, Horvitz, Robert H.

“…Here, we describe a systematic search for synthetic gene interactions in a multicellular organism, the nematode Caenorhabditis elegans. We established a…”
Get full text

Frequent Germline Mutations and Somatic Repeat Instability in DNA Mismatch-Repair-Deficient Caenorhabditis elegans by Tijsterman, Marcel, Pothof, Joris, Plasterk, Ronald H. A

“…Mismatch-repair-deficient mutants were initially recognized as mutation-prone derivatives of bacteria, and later mismatch repair deficiency was found to…”
Get full text

The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2[alpha] by Gort, E H, Van Haaften, G, Verlaan, I, Groot, A J, Plasterk, R H A, Shvarts, A, Suijkerbuijk, K P M, Van Laar, T, Van Der Wall, E, Raman, V, Van Diest, P J, Tijsterman, M, Vooijs, M

“…Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that play a crucial role in oxygen homeostasis. Intratumoral hypoxia and genetic…”
Get full text