Search Results - "Tihanyi, Karoly"

Cariprazine (RGH-188), a potent D 3/D 2 dopamine receptor partial agonist, binds to dopamine D 3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents by Gyertyán, István, Kiss, Béla, Sághy, Katalin, Laszy, Judit, Szabó, Györgyi, Szabados, Tamás, Gémesi, Larisza I., Pásztor, Gabriella, Zájer-Balázs, Mária, Kapás, Margit, Csongor, Éva Ágai, Domány, György, Tihanyi, Károly, Szombathelyi, Zsolt

“…[Display omitted] ► Cariprazine, a D 3/D 2 partial agonist potently bound rat D 3 and D 2 receptors in vivo. ► Cariprazine had high potency and efficacy in…”
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Estradiol and isotype-selective estrogen receptor agonists modulate the mesocortical dopaminergic system in gonadectomized female rats by Sárvári, Miklós, Deli, Levente, Kocsis, Pál, Márk, László, Maász, Gábor, Hrabovszky, Erik, Kalló, Imre, Gajári, Dávid, Vastagh, Csaba, Sümegi, Balázs, Tihanyi, Károly, Liposits, Zsolt

“…Abstract The mesocortical dopaminergic pathway projecting from the ventral tegmental area (VTA) to the prefrontal cortex (PFC) contributes to the processing of…”
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Effect of tolperisone on the resting brain and on evoked responses, an phMRI BOLD study by Kocsis, Pál, Gajári, Dávid, Deli, Levente, Gőcze, Krisztina Zsedrovitsné, Pozsgay, Zsófia, Tihanyi, Károly

“…Highlights • Tolperisone has no effect on BOLD responses in the resting brain. • Electric paw stimulation caused BOLD increase in several brain areas. •…”
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Scopolamine provocation-based pharmacological MRI model for testing procognitive agents by Hegedűs, Nikolett, Laszy, Judit, Gyertyán, István, Kocsis, Pál, Gajári, Dávid, Dávid, Szabolcs, Deli, Levente, Pozsgay, Zsófia, Tihanyi, Károly

“…There is a huge unmet need to understand and treat pathological cognitive impairment. The development of disease modifying cognitive enhancers is hindered by…”
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Vascular Action as the Primary Mechanism of Cognitive Effects of Cholinergic, CNS-Acting Drugs, a Rat phMRI BOLD Study by Kocsis, Pál, Gyertyán, István, Éles, János, Laszy, Judit, Hegedüs, Nikolett, Gajári, Dávid, Deli, Levente, Pozsgay, Zsófia, Dávid, Szabolcs, Tihanyi, Károly

“…Concordant results of functional magnetic resonance imaging (fMRI) and behavioral tests prove that some non-blood-brain barrier-penetrating drugs produce…”
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NMR analysis, protonation equilibria and decomposition kinetics of tolperisone by Orgován, Gábor, Tihanyi, Károly, Noszál, Béla

“…The rate constants of spontaneous and hydroxide-catalyzed decomposition and the tautomer-specific protonation constants of tolperisone, a classical muscle…”
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Neuroprotective Effects of Vinpocetine and its Major Metabolite Cis‐apovincaminic Acid on NMDA‐Induced Neurotoxicity in a Rat Entorhinal Cortex Lesion Model by Nyakas, Csaba, Felszeghy, Klára, Szabó, Róbert, Keijser, Jan N., Luiten, Paul G.M., Szombathelyi, Zsolt, Tihanyi, Károly

“…Vinpocetine (ethyl‐apovincaminate, Cavinton), a synthetic derivative of the Vinca minor alkaloid vincamine, has been used now for decades for prevention and…”
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Comparison of brain capillary endothelial cell-based and epithelial (MDCK-MDR1, Caco-2, and VB-Caco-2) cell-based surrogate blood–brain barrier penetration models by Hellinger, Éva, Veszelka, Szilvia, Tóth, Andrea E., Walter, Fruzsina, Kittel, Ágnes, Bakk, Mónika Laura, Tihanyi, Károly, Háda, Viktor, Nakagawa, Shinsuke, Dinh Ha Duy, Thuy, Niwa, Masami, Deli, Mária A., Vastag, Monika

“…Functional and morphological comparison of the primary endothelial triple co-culture blood–brain barrier (BBB) model, the high P-glycoprotein expressing…”
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Physico-chemical characterization of a novel group of dopamine D 3/D 2 receptor ligands, potential atypical antipsychotic agents by Deák, Katalin, Takács-Novák, Krisztina, Kapás, Margit, Vastag, Mónika, Tihanyi, Károly, Noszál, Béla

“…The fundamental physico-chemical properties such as ionization and lipophilicity of twelve alkyl–aryl-piperidine and aryl-piperazine derivatives have been…”
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Cell-based models of blood-brain barrier penetration by Vastag, Monika, Hellinger, Eva, Bakk, Mónika L, Tihanyi, Károly

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Identification of Metabolic Pathways Involved in the Biotransformation of Tolperisone by Human Microsomal Enzymes by DALMADI, Balazs, LEIBINGER, Janos, SZEBERENYI, Szabolcs, BORBAS, Timea, FARKAS, Sandor, SZOMBATHELYI, Zsolt, TIHANYI, Karoly

“…The in vitro metabolism of tolperisone, 1-(4-methyl-phenyl)-2-methyl-3-(1-piperidino)-1-propanone-hydrochloride, a centrally acting muscle relaxant, was…”
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Physico-chemical profiling of antidepressive sertraline: solubility, ionisation, lipophilicity by Deák, Katalin, Takács-Novák, Krisztina, Tihanyi, Károly, Noszál, Béla

“…The fundamental physico-chemical parameters of sertraline, a potent selective serotonin reuptake inhibitor and reference compound in the development of new…”
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Estradiol Replacement Alters Expression of Genes Related to Neurotransmission and Immune Surveillance in the Frontal Cortex of Middle-Aged, Ovariectomized Rats by Sárvári, Miklós, Kalló, Imre, Hrabovszky, Erik, Solymosi, Norbert, Tóth, Kinga, Likó, István, Molnár, Béla, Tihanyi, Károly, Liposits, Zsolt

“…Estradiol (E2) modulates a wide range of functions of the frontal cerebral cortex. From the onset of menopause, declining levels of E2 can cause cognitive…”
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Concerted action of antiepileptic and antidepressant agents to depress spinal neurotransmission: Possible use in the therapy of spasticity and chronic pain by Thán, Márta, Kocsis, Pál, Tihanyi, Károly, Fodor, László, Farkas, Bence, Kovács, Gyula, Kis-Varga, Ágnes, Szombathelyi, Zsolt, Tarnawa, István

“…Chronic pain states and epilepsies are common therapeutic targets of voltage-gated sodium channel blockers. Inhibition of sodium channels results in central…”
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The new 2,3-benzodiazepine derivative EGIS-8332 inhibits AMPA/kainate ion channels and cell death by Vegh, Miklos G., Kovács, Attila D., Kovács, Gábor, Szabó, Géza, Tihanyi, Károly, Hársing, László G., Lévay, György

“…We observed in vitro neuroprotective and AMPA/kainate receptor antagonist effects of the new 2,3-benzodiazepine derivative EGIS-8332 ( R,…”
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Ghrelin modulates the fMRI BOLD response of homeostatic and hedonic brain centers regulating energy balance in the rat by Sárvári, Miklós, Kocsis, Pál, Deli, Levente, Gajári, Dávid, Dávid, Szabolcs, Pozsgay, Zsófia, Hegedűs, Nikolett, Tihanyi, Károly, Liposits, Zsolt

“…The orexigenic gut-brain peptide, ghrelin and its G-protein coupled receptor, the growth hormone secretagogue receptor 1a (GHS-R1A) are pivotal regulators of…”
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Translocator protein (TSPO 18kDa) is expressed by neural stem and neuronal precursor cells by Varga, Balázs, Markó, Károly, Hádinger, Nóra, Jelitai, Márta, Demeter, Kornél, Tihanyi, Károly, Vas, Ádám, Madarász, Emília

“…Translocator protein 18kDa, the peripheral benzodiazepine receptor by its earlier name, is a mitochondrial membrane protein associated with the mitochondrial…”
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Drug penetration model of vinblastine-treated Caco-2 cultures by Hellinger, Éva, Bakk, Mónika Laura, Pócza, Péter, Tihanyi, Károly, Vastag, Monika

“…The penetrability of new chemical entities (NCE) is routinely screened in preclinical drug research. Although Caco-2 is a well-established model for human…”
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Gene Expression Profiling Identifies Key Estradiol Targets in the Frontal Cortex of the Rat by Sárvári, Miklós, Hrabovszky, Erik, Kalló, Imre, Galamb, Orsolya, Solymosi, Norbert, Likó, István, Molnár, Béla, Tihanyi, Károly, Szombathelyi, Zsolt, Liposits, Zsolt

“…Estradiol modulates a wide range of neural functions in the frontal cerebral cortex where subsets of neurons express estrogen receptor-α and -β. Through these…”
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Synthesis and evaluation of 5-HT2A and 5-HT2C receptor binding affinities of novel pyrimidine derivatives by BOZSING, Daniel, SIMONEK, Ildiko, SIMIG, Gyula, JAKOCZI, Ivan, GACSALYI, Istvan, LEVAY, György, TIHANYI, Karoly, SCHMIDT, Eva

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