Search Results - "Tighe, P J"

Limbal epithelial crypts: a novel anatomical structure and a putative limbal stem cell niche by Dua, H S, Shanmuganathan, V A, Powell-Richards, A O, Tighe, P J, Joseph, A

“…Background/aims: There is substantial evidence that mammalian epithelial stem cells are located within well defined niches. Although the corneoscleral limbus…”
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Systemic cytokine levels and the effects of etanercept in TNF receptor-associated periodic syndrome (TRAPS) involving a C33Y mutation in TNFRSF1A by Nowlan, M. L., Drewe, E., Bulsara, H., Esposito, N., Robins, R. A., Tighe, P. J., Powell, R. J., Todd, I.

“…Objective. To investigate the levels of the pro-inflammatory cytokines IL-6, TNF-α, IL-1β, IL-8, IL-10 and IL-12p70 in the plasma of patients with TNF…”
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Differential expression of TGF-beta isoforms by normal and inflammatory bowel disease intestinal myofibroblasts by McKaig, B C, Hughes, K, Tighe, P J, Mahida, Y R

“…Intestinal strictures are frequent in Crohn's disease but not ulcerative colitis. We investigated the expression of transforming growth factor (TGF)-beta…”
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Noninvasive tissue oxygen saturation determined by near-infrared spectroscopy following peripheral nerve block by TIGHE, P.J., ELLIOTT, C.E., LUCAS, S.D., BOEZAART, A.P.

“…Background Noninvasive physiologic measurement of cutaneous tissue oxygenation using near‐infrared spectroscopy (NIRS) has become increasingly common in…”
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Multiple protein extract microarray for profiling human food-specific immunoglobulins A, M, G and E by Renault, N.K., Gaddipati, S.R., Wulfert, F., Falcone, F.H., Mirotti, L., Tighe, P.J., Wright, V., Alcocer, M.J.C.

“…Existing food immunoglobulin (Ig) tests require large volumes of serum, are limited to one immunoglobulin class, are not amenable to high throughput analysis…”
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Antimicrobial defensin peptides of the human ocular surface by Haynes, Richard John, Tighe, Patrick Jason, Dua, Harminder Singh

“…BACKGROUND/AIMS The antimicrobial activity of the tear film exceeds the activity of its known constituents. The authors postulate that this excess activity is…”
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Treatment of Erdheim-Chester disease with cladribine: a rational approach by Myra, C, Sloper, L, Tighe, P J, McIntosh, R S, Stevens, S E, Gregson, R H S, Sokal, M, Haynes, A P, Powell, R J

“…[...]his thyroid function was normal, but erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) were moderately elevated. Treatments have included…”
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Immunocompromised children and young people are at no increased risk of severe COVID-19 by Chappell, H., Patel, R., Driessens, C., Tarr, A.W., Irving, W.L., Tighe, P.J., Jackson, H.J., Harvey-Cowlishaw, T., Mills, L., Shaunak, M., Gbesemete, D., Leahy, A., Lucas, J.S., Faust, S.N., de Graaf, H.

“…•UK immunocompromised paediatric patients were at no increased risk of severe COVID-19.•Only 4/38 PCR detected infections were admitted to hospital. None had…”
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Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells by Jean-Gilles, L., Braitch, M., Latif, M. L., Aram, J., Fahey, A. J., Edwards, L. J., Robins, R. A., Tanasescu, R., Tighe, P. J., Gran, B., Showe, L. C., Alexander, S. P., Chapman, V., Kendall, D. A., Constantinescu, C. S.

“…Aims To investigate the regulation of cannabinoid receptors CB1 and CB2 on immune cells by pro‐inflammatory cytokines and its potential relevance to the…”
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Patients with tumour necrosis factor (TNF) receptor‐associated periodic syndrome (TRAPS) are hypersensitive to Toll‐like receptor 9 stimulation by Negm, O. H., Singh, S., Abduljabbar, W., Hamed, M. R, Radford, P., McDermott, E. M., Drewe, E., Fairclough, L., Todd, I., Tighe, P. J.

“…Summary Tumour necrosis factor receptor‐associated periodic syndrome (TRAPS) is a hereditary autoinflammatory disorder characterized by recurrent episodes of…”
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Natural and disease‐specific autoantibodies in chronic obstructive pulmonary disease by Daffa, N. I., Tighe, P. J., Corne, J. M., Fairclough, L. C., Todd, I.

“…Summary Autoimmunity may contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD). Studies have identified disease‐specific…”
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Inactivation of the Fas gene by Alu insertion: retrotransposition in an intron causing splicing variation and autoimmune lymphoproliferative syndrome by Tighe, P J, Stevens, S E, Dempsey, S, Le Deist, F, Rieux-Laucat, F, Edgar, J D M

“…Mutations in the Fas (apo-1, CD95) gene result in autoimmune lymphoproliferative syndrome (ALPS). These mutations are dominated by small deletions and point…”
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Intravitreal invading cells contribute to vitreal cytokine milieu in proliferative vitreoretinopathy by El-Ghrably, I A, Dua, Harminder S, Orr, Gavin M, Fischer, David, Tighe, Patrick J

“…AIM To examine the contribution of infiltrating cells in the local production of cytokines within the vitreous of patients with proliferative vitreoretinopathy…”
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Innate defence of the eye by antimicrobial defensin peptides by Haynes, RJ, Tighe, PJ, Dua, HS

“…Haynes et al looked for human defensin subclasses in the eye. Defensincs are antimicrobial peptides with activity against gram-positive and gram-negative…”
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Distinct antigenic features of linear epitopes at the N‐terminus and C‐terminus of 65 kDa glutamic acid decarboxylase (GAD65): implications for autoantigen modification during pathogenesis by AL‐BUKHARI, T. A. M. A., RADFORD, P. M., BOURAS, G., DAVENPORT, C., TRIGWELL, S. M., BOTTAZZO, G.‐F., LAI, M., SCHWARTZ, H. L., TIGHE, P. J., TODD, I.

“…Summary Autoantibodies to 65 kDa glutamic acid decarboxylase (GAD65) are produced in many patients with autoimmune polyendocrine syndrome type II (APS‐II) or…”
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The use of phage-peptide libraries to define the epitope specificity of a mouse monoclonal anti-Der p 1 antibody representative of a major component of the human immunoglobulin E anti-Der p 1 response by FURMONAVICIENE, R, TIGHE, P. J, CLARK, M. R, SEWELL, H. F, SHAKIB, F

“…Background More than 80% of individuals who are sensitive to the dust mite Dermatophagoides pteronyssinus produce immunoglobulin (Ig) E antibodies to Der p 1,…”
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Expression of Human Beta-Defensins in Intraocular Tissues by Haynes, Richard John, McElveen, Jane Elizabeth, Dua, Harminder Singh, Tighe, Patrick Jason, Liversidge, Janet

“…Defensins are naturally occurring antimicrobial peptides. Recently the authors published evidence of defensin production by the human ocular surface. A study…”
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Detection of cytokine mRNA production in infiltrating cells in proliferative vitreoretinopathy using reverse transcription polymerase chain reaction by El-Ghrably, I A, Dua, Harminder S, Orr, Gavin M, Fischer, David, Tighe, Patrick J

“…AIMS To determine whether the infiltrating cells in the vitreous and subretinal fluid of patients with proliferative vitreoretinopathy (PVR) express messenger…”
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Antibodies from systemic lupus erythematosus (SLE) sera define differential release of autoantigens from cell lines undergoing apoptosis by HUGGINS, M. L, TODD, I, CAVERS, M. A, PAVULURI, S. R, TIGHE, P. J, POWELL, R. J

“…SLE is an autoimmune disease characterized by a wide range of anti‐cellular and anti‐nuclear autoantibodies. Many of these antigens are exposed or altered…”
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Differential Gene Expression during Meningeal-Meningococcal Interaction: Evidence for Self-Defense and Early Release of Cytokines and Chemokines by WELLS, Damien B, TIGHE, Patrick J, WOOLDRIDGE, Karl G, ROBINSON, Karen, ALAA' LDEEN, Dlawer A. A

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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