Search Results - "Tighe, Kayla M."

Erwinia asparaginase (crisantaspase) increases plasma levels of serine and glycine by Bollino, Dominique, Claiborne, J Preston, Hameed, Kanwal, Ma, Xinrong, Tighe, Kayla M, Carter-Cooper, Brandon, Lapidus, Rena G, Strovel, Erin T, Emadi, Ashkan

“…The impact of asparaginases on plasma asparagine and glutamine is well established. However, the effect of asparaginases, particularly those derived from (also…”
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Long-acting Erwinia chrysanthemi, Pegcrisantaspase, induces alternate amino acid biosynthetic pathways in a preclinical model of pancreatic ductal adenocarcinoma by Bollino, Dominique, Hameed, Kanwal, Bhat, Anusha, Zarrabi, Arveen, Casildo, Andrea, Ma, Xinrong, Tighe, Kayla M, Carter-Cooper, Brandon, Strovel, Erin T, Lapidus, Rena G, Emadi, Ashkan

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease without meaningful therapeutic options beyond the first salvage therapy. Targeting PDAC…”
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Community-engaged basic science in an NCI-designated comprehensive cancer center: antioxidants and chemotherapeutic efficacy by Bollino, Dominique, Woodard, Nathaniel, Tighe, Kayla M., Ma, Xinrong, Casildo, Andrea, D’Adamo, Christopher R., Emadi, Ashkan, Knott, Cheryl L.

“…Purpose While community engagement has been a longstanding aspect of cancer-relevant research in social and behavioral sciences, it is far less common in…”
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Venetoclax and pegcrisantaspase for complex karyotype acute myeloid leukemia by Emadi, Ashkan, Kapadia, Bandish, Bollino, Dominique, Bhandary, Binny, Baer, Maria R., Niyongere, Sandrine, Strovel, Erin T., Kaizer, Hannah, Chang, Elizabeth, Choi, Eun Yong, Ma, Xinrong, Tighe, Kayla M., Carter-Cooper, Brandon, Moses, Blake S., Civin, Curt I., Mahurkar, Anup, Shetty, Amol C., Gartenhaus, Ronald B., Kamangar, Farin, Lapidus, Rena G.

“…Complex karyotype acute myeloid leukemia (CK-AML) has a dismal outcome with current treatments, underscoring the need for new therapies. Here, we report…”
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Long-Acting E. coli-Derived Asparaginase Potentiates the Anti-Leukemic Effect of BCL2 Inhibition, but Not MCL1 Inhibition, in Preclinical Models of Acute Myeloid Leukemia by Bollino, Dominique, Casildo, Andrea, Ma, Xinrong, Tighe, Kayla M, Carter-Cooper, Brandon, Emadi, Ashkan

“…Background: Asparaginases are enzymes that deplete circulating asparagine and glutamine from plasma and can therefore be used therapeutically for cancers that…”
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Comprehensive Plasma Amino Acid Analysis Following Administration of Short- and Long-Acting Erwinia Asparaginase (Crisantaspase) Demonstrated Significant Increase in Plasma Serine and Glycine Levels by Bollino, Dominique R, Claiborne, J Preston, Mahmood, Kanwal, Ma, Xinrong, Tighe, Kayla M, Cooper, Brandon, Lapidus, Rena G., Strovel, Erin T, Emadi, Ashkan

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Abstract 4047: Pegcrisantaspase-based combination therapies for the treatment of pancreatic adenocarcinoma by Bollino, Dominique, Nerone, Sophie, Ma, Xinrong, Tighe, Kayla M., Carter-Cooper, Brandon, Lapidus, Rena G., Emadi, Ashkan

“…Abstract Pancreatic adenocarcinoma is one of the most aggressive human cancer types and is predicted to be the second leading cause of cancer-related deaths in…”
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