Search Results - "Tiffany, Matthew"

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes by Sockolosky, Jonathan T, Trotta, Eleonora, Parisi, Giulia, Picton, Lora, Su, Leon L, Le, Alan C, Chhabra, Akanksha, Silveria, Stephanie L, George, Benson M, King, Indigo C, Tiffany, Matthew R, Jude, Kevin, Sibener, Leah V, Baker, David, Shizuru, Judith A, Ribas, Antoni, Bluestone, Jeffrey A, Garcia, K Christopher

“…Interleukin-2 (IL-2) is a cytokine required for effector T cell expansion, survival, and function, especially for engineered T cells in adoptive cell…”
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Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling by Ho, Chia Chi M., Chhabra, Akanksha, Starkl, Philipp, Schnorr, Peter-John, Wilmes, Stephan, Moraga, Ignacio, Kwon, Hye-Sook, Gaudenzio, Nicolas, Sibilano, Riccardo, Wehrman, Tom S., Gakovic, Milica, Sockolosky, Jonathan T., Tiffany, Matthew R., Ring, Aaron M., Piehler, Jacob, Weissman, Irving L., Galli, Stephen J., Shizuru, Judith A., Garcia, K. Christopher

“…Most secreted growth factors and cytokines are functionally pleiotropic because their receptors are expressed on diverse cell types. While important for normal…”
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Improving the distribution of Doxil® in the tumor matrix by depletion of tumor hyaluronan by Kohli, Aditya G., Kivimäe, Saul, Tiffany, Matthew R., Szoka, Francis C.

“…Liposomes improve the pharmacokinetics and safety of rapidly cleared drugs, but have not yet improved the clinical efficacy compared to the non-encapsulated…”
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Engineering neonatal Fc receptor-mediated recycling and transcytosis in recombinant proteins by short terminal peptide extensions by Sockolosky, Jonathan T, Tiffany, Matthew R, Szoka, Francis C

“…The importance of therapeutic recombinant proteins in medicine has led to a variety of tactics to increase their circulation time or to enable routes of…”
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Using a barcoded AAV capsid library to select for clinically relevant gene therapy vectors by Pekrun, Katja, De Alencastro, Gustavo, Luo, Qing-Jun, Liu, Jun, Kim, Youngjin, Nygaard, Sean, Galivo, Feorillo, Zhang, Feijie, Song, Ren, Tiffany, Matthew R, Xu, Jianpeng, Hebrok, Matthias, Grompe, Markus, Kay, Mark A

“…While gene transfer using recombinant adeno-associated viral (rAAV) vectors has shown success in some clinical trials, there remain many tissues that are not…”
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Synthesis, Characterization, and Evaluation of Ionizable Lysine-Based Lipids for siRNA Delivery by Walsh, Colin L, Nguyen, Juliane, Tiffany, Matthew R, Szoka, Francis C

“…We report the synthesis and characterization of a series of ionizable lysine-based lipids (ILL), novel lipids containing a lysine headgroup linked to a…”
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Screening for Autism Spectrum Disorders by Grissom, Maureen, PhD, Tiffany, Matthew, MD, Davidson, Laurie, MLIS, MEd

“…A systematic review included four cohort studies (N > 15,000 children) that evaluated the M-CHAT in screening for ASDs in low-risk children (defined as those…”
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253. Expanded Packaging Capacity of AAV by Lumenal Charge Alteration by Tiffany, Matthew, Kay, Mark A.

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Tracking Adeno-Associated Virus Capsid Evolution by High-Throughput Sequencing by de Alencastro, Gustavo, Pekrun, Katja, Valdmanis, Paul, Tiffany, Matthew, Xu, Jianpeng, Kay, Mark A

“…Despite early successes using recombinant adeno-associated virus (rAAV) vectors in clinical gene therapy trials, limitations remain making additional…”
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94. AAV Integration Site Determination Using Illumina Mate Pair Sequencing by Tiffany, Matthew R., Kay, Mark A.

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Evaluating the Genomic Parameters Governing rAAV-Mediated Homologous Recombination by Spector, Laura P., Tiffany, Matthew, Ferraro, Nicole M., Abell, Nathan S., Montgomery, Stephen B., Kay, Mark A.

“…Recombinant adeno-associated virus (rAAV) vectors have the unique ability to promote targeted integration of transgenes via homologous recombination at…”
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Co-localization of fluorescent labeled lipid nanoparticles with specifically tagged subcellular compartments by single particle tracking at low nanoparticle to cell ratios by Tiffany, Matthew, Szoka, Francis C.

“…We utilized quantitative high-resolution single particle tracking to study the internalization and endosomal sorting of lipid nanoparticles (LNPs) by HeLa…”
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Improved Genome Editing through Inhibition of FANCM and Members of the BTR Dissolvase Complex by de Alencastro, Gustavo, Puzzo, Francesco, Pavel-Dinu, Mara, Zhang, Feijie, Pillay, Sirika, Majzoub, Karim, Tiffany, Matthew, Jang, Hagoon, Sheikali, Adam, Cromer, M. Kyle, Meetei, Ruhikanta, Carette, Jan E., Porteus, Matthew H., Pekrun, Katja, Kay, Mark A.

“…Recombinant adeno-associated virus (rAAV) vectors have the unique property of being able to perform genomic targeted integration (TI) without inducing a…”
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Engineering neonatal Fc receptor-mediated recycling and transcytosis in recombinant proteins by short terminal peptide extensions by Sockolosky, Jonathan T, Tiffany, Matthew R, Szoka, Francis C

“…The importance of therapeutic recombinant proteins in medicine has led to a variety of tactics to increase their circulation time or to enable routes of…”
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Influence of Multivalent Nitrilotriacetic Acid Lipid−Ligand Affinity on the Circulation Half-Life in Mice of a Liposome-Attached His6-Protein by Platt, Virginia, Huang, Zhaohua, Cao, Limin, Tiffany, Matthew, Riviere, Kareen, Szoka, Francis C

“…Metal chelation−ligand interactions, such as occur between nitrilotriacetic acid (NTA)-nickel and multihistidines, enable the noncovalent attachment of…”
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722. AAV Capsid Evolution for Enhanced Antibody Delivery to Human Skeletal Muscle for Use in Next-Generation HIV Vaccines and Muscle Gene Therapies by Paulk, Nicole K., Charville, Gregory, Maguire, Katie, Pekrun, Katja, Zhang, Yue, Tiffany, Matthew, Vilches-Moure, Jose, Lee, Gordon, Shrager, Joseph, Rando, Thomas, Kay, Mark A.

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FPIN's Clinical Inquiries. Screening for autism spectrum disorders by Grissom, Maureen, Tiffany, Matthew, Davidson, Laurie

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Influence of Multivalent Nitrilotriacetic Acid Lipid-Ligand Affinity on the Circulation Half-Life in Mice of a Liposome-Attached His^sub 6^-Protein by Platt, Virginia, Huang, Zhaohua, Cao, Limin, Tiffany, Matthew, Riviere, Kareen, Szoka, Francis C

“…Metal chelation-ligand interactions, such as occur between nitrilotriacetic acid (NTA)-nickel and multihistidines, enable the noncovalent attachment of…”
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Influence of Multivalent Nitrilotriacetic Acid Lipid−Ligand Affinity on the Circulation Half-Life in Mice of a Liposome-Attached His 6 -Protein by Platt, Virginia, Huang, Zhaohua, Cao, Limin, Tiffany, Matthew, Riviere, Kareen, Szoka, Francis C.

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Tracking Fluorescent Liposomes and Fluorescent siRNA Contents During Internalization and Trafficking in Cultured Cells by Tiffany, Matthew R

“…The large molecular weight, poly-anionic, and labile nature of small interfering RNA (siRNA) necessitate that these macromolecules are associated with carriers…”
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