Search Results - "Tiffany, Carol"

Prostate-specific membrane antigen (PSMA) enzyme activity is elevated in prostate cancer cells by Lapidus, Rena G., Tiffany, Carol W., Isaacs, John T., Slusher, Barbara S.

“…BACKGROUND Prostate‐specific membrane antigen (PSMA) is a glutamate carboxypeptidase that cleaves terminal carboxy glutamates from both the neuronal dipeptide…”
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Improved statistical analysis of budding yeast TAG microarrays revealed by defined spike-in pools by Peyser, Brian D., Irizarry, Rafael A., Tiffany, Carol W., Chen, Ou, Yuan, Daniel S., Boeke, Jef D., Spencer, Forrest A.

“…Saccharomyces cerevisiae knockout collection TAG microarrays are an emergent platform for rapid, genome-wide functional characterization of yeast genes. TAG…”
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Binding of the glutamate carboxypeptidase II (NAALADase) inhibitor 2-PMPA to rat brain membranes by Tiffany, Carol W, Cai, Ning S, Rojas, Camilo, Slusher, Barbara S

“…2-Phosphonomethyl pentanedioic acid (2-PMPA) is a potent and selective inhibitor of glutamate carboxypeptidase II (NAALADase), and has shown robust…”
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Dendrimer–N‐acetyl‐L‐cysteine modulates monophagocytic response in adrenoleukodystrophy by Turk, Bela R., Nemeth, Christina L., Marx, Joel S., Tiffany, Carol, Jones, Richard, Theisen, Benjamin, Kambhampati, Siva, Ramireddy, Raj, Singh, Sarabdeep, Rosen, Melissa, Kaufman, Miriam L., Murray, Connor F., Watkins, Paul A., Kannan, Sujatha, Kannan, Rangaramanujam, Fatemi, Ali

“…Objective X‐linked adrenoleukodystrophy (ALD) is a neurodegenerative disorder due to mutations in the peroxisomal very long‐chain fatty acyl‐CoA transporter,…”
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Antioxidant Capacity and Superoxide Dismutase Activity in Adrenoleukodystrophy by Turk, Bela R, Theisen, Benjamin E, Nemeth, Christina L, Marx, Joel S, Shi, Xiaohai, Rosen, Melissa, Jones, Richard O, Moser, Ann B, Watkins, Paul A, Raymond, Gerald V, Tiffany, Carol, Fatemi, Ali

“…X-linked adrenoleukodystrophy (ALD) may switch phenotype to the fatal cerebral form (ie, cerebral ALD [cALD]), the cause of which is unknown. Determining…”
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Measurement of glutamate carboxypeptidase II (NAALADase) enzyme activity by the hydrolysis of [³H]-N-acetylaspartylglutamate (NAAG) by Tiffany, Carol W, Slusher, Barbara S

“…The peptide N-Acetylaspartylglutamate (NAAG) is hydrolyzed by N-Acetylated-alpha-linked-acidic dipeptidase (NAALADase, glutamate carboxypeptidase II) into…”
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Bradykinin stimulates tumor necrosis factor and interleukin-1 release from macrophages by Tiffany, Carol W., Burch, Ronald M.

“…Bradykinin and related kinins have been implicated in the initiation and maintenance of inflammation. Cytokines appear to be the primary mediators of many…”
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Bridged .gamma.-carbolines and derivatives possessing selective and combined affinity for 5-HT2 and D2 receptors by Mewshaw, Richard E, Silverman, Lisa S, Mathew, Rose M, Kaiser, Carl, Sherrill, Ronald G, Cheng, Menyan, Tiffany, Carol W, Karbon, E. William, Bailey, Michael A

“…A series of 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles and 6,7,8,9,10,11-hexahydro-7,11-imino-5H-cyclooct[b]indoles was prepared. Structural…”
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Investigational methods for peroxisomal disorders by Steinberg, Steven, Jones, Richard, Tiffany, Carol, Moser, Ann

“…Peroxisomes play an important role in cellular metabolism. Defects in peroxisome assembly or of a single peroxisomal pathway are associated with a wide variety…”
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Examination of the D2/5-HT2 affinity ratios of resolved 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: an enantioselective approach toward the design of potential atypical antipsychotics by Mewshaw, Richard E, Abreu, Mary E, Silverman, Lisa S, Mathew, Rose M, Tiffany, Carol W, Bailey, Michael A, Karbon, E. William, Ferkany, John W, Kaiser, Carl

“…Enantiomers of several N-substituted 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles were obtained by the resolution of…”
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Postoperative femoral motor neuropathy : Diagnosis and treatment without neurologic consultation or testing by FANNING, James, CAROL, Tiffany, MILLER, Dawn, FLORA, Robert

“…To review the diagnosis and treatment of postoperative femoral motor neuropathy without neurologic consultation or testing. A retrospective review of 6…”
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Analysis of genetic interactions on a genome-wide scale in budding yeast: diploid-based synthetic lethality analysis by microarray by Meluh, Pamela B, Pan, Xuewen, Yuan, Daniel S, Tiffany, Carol, Chen, Ou, Sookhai-Mahadeo, Sharon, Wang, Xiaoling, Peyser, Brian D, Irizarry, Rafael, Spencer, Forrest A, Boeke, Jef D

“…Comprehensive collections of open reading frame (ORF) deletion mutant strains exist for the budding yeast Saccharomyces cerevisiae. With great prescience,…”
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Characterization of the enzymatic activity of PSM: Comparison with brain NAALADase by Tiffany, Carol W., Lapidus, Rena G., Merion, Aviva, Calvin, David C., Slusher, Barbara S.

“…BACKGROUND The prostate cancer marker prostate‐specific membrane antigen (PSM) is highly homologous to the brain enzyme N‐acetylated alpha‐linked acidic…”
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Use of identical assay conditions for cocaine analog binding and dopamine uptake to identify potential cocaine antagonists by Slusher, Barbara S., Tiffany, Carol W., Olkowski, Jennifer L., Jackson, Paul F.

“…The addictive and euphorogenic properties of cocaine are thought to result from inhibition of the dopamine transporter (DAT). Recent evidence suggests that…”
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N-(Fluorenyl-9-Methoxycarbonyl) Amino Acids, a Class of Antiinflammatory Agents With a different Mechanism of Action by Burch, Ronald M., Weitzberg, Moshe, Blok, Natalie, Muhlhauser, Richard, Martin, David, Farmer, Stephen G., Bator, Jenny M., Connor, Jane R., Ko, Chiew, Kuhn, Wendy, McMillan, Barbara A., Raynor, Maureen, Shearer, Barry G., Tiffany, Carol, Wilkins, Deidre E.

“…Several members of a series of N-(fluorenyl-9-methoxycarbonyl) amino acids were found to possess a broad spectrum of antiinflammatory activity. The compounds…”
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Suramin potently inhibits the enzymatic activity of PSM by Slusher, Barbara S., Tiffany, Carol W., Merion, Aviva, Lapidus, Rena G., Jackson, Paul F.

“…BACKGROUND The polysulfonated napthlyurea suramin has shown significant antitumor activity in patients with hormone‐refractory metastatic prostate cancer. The…”
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Tumor necrosis factor causes amplification of arachidonic acid metabolism in response to interleukin 1, bradykinin, and other agonists by Burch, R M, Tiffany, C W

“…Tumor necrosis factor stimulated prostaglandin E2 synthesis in Swiss 3T3 fibroblasts. Interleukin 1 also stimulated prostaglandin synthesis. Simultaneous…”
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Prolonged Survival and Remyelination after Hematopoietic Cell Transplantation in the Twitcher Mouse by Yeager, Andrew M., Brennan, Susan, Tiffany, Carol, Moser, Hugo W., Santos, George W.

“…The twitcher mouse is an animal model of galactosylceramidase deficiency (Krabbe's disease), a human sphingolipidosis. The effects of hematopoietic cell…”
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NPC 15437 interacts with the C1 domain of protein kinase C An analysis using mutant PKC constructs by Sullivan, James P., Connor, Jane R., Tiffany, Carol, Shearer, Barry G., Burch, Ronald M.

“…We recently demonstrated that 2,6,diamino- N-([I-(oxotridecyl)-2-piperidinyl]methyl)-hexanamide (NPC 15437) is a selective inhibitor of PKC interacting at the…”
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Arachidonic acid metabolism in fibroblasts from patients with peroxisomal diseases: response to interleukin 1 by Tiffany, C W, Hoefler, S, Moser, H W, Burch, R M

“…Prostaglandin E2 synthesis and eicosanoid biosynthetic enzyme activities (arachidonyl CoA synthetase, cyclooxygenase and phospholipase A2) were measured in…”
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