Search Results - "Tieu, Kim"

Exosomes in Parkinson disease by Pinnell, Jennifer R., Cui, Mei, Tieu, Kim

“…Parkinson disease (PD) is a prevalent neurodegenerative disease, in which the formation of misfolded and aggregated α‐synuclein is a key neuropathological…”
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Astrocytes and Therapeutics for Parkinson's Disease by Rappold, Phillip M., Tieu, Kim

“…Astrocytes play direct, active, and critical roles in mediating neuronal survival and function in various neurodegenerative disorders. This role of astrocytes…”
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Manganese-Induced Parkinsonism: Evidence from Epidemiological and Experimental Studies by Lucchini, Roberto, Tieu, Kim

“…Manganese (Mn) exposure has evolved from acute, high-level exposure causing manganism to low, chronic lifetime exposure. In this latter scenario, the target…”
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Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson’s disease by Bido, Simone, Soria, Federico N., Fan, Rebecca Z., Bezard, Erwan, Tieu, Kim

“…Alpha-synuclein (α-syn) is involved in both familial and sporadic Parkinson’s disease (PD). One of the proposed pathogenic mechanisms of α-syn mutations is…”
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Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity by Lovatt, Ditte, Xu, Qiwu, Liu, Wei, Takano, Takahiro, Smith, Nathan A, Schnermann, Jurgen, Tieu, Kim, Nedergaard, Maiken

“…Adenosine is a potent anticonvulsant acting on excitatory synapses through A1 receptors. Cellular release of ATP, and its subsequent extracellular enzymatic…”
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Glutathione dysregulation and the etiology and progression of human diseases by Ballatori, Nazzareno, Krance, Suzanne M, Notenboom, Sylvia, Shi, Shujie, Tieu, Kim, Hammond, Christine L

“…Glutathione (GSH) plays an important role in a multitude of cellular processes, including cell differentiation, proliferation, and apoptosis, and as a result,…”
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Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo by Rappold, Phillip M., Cui, Mei, Grima, Jonathan C., Fan, Rebecca Z., de Mesy-Bentley, Karen L., Chen, Linan, Zhuang, Xiaoxi, Bowers, William J., Tieu, Kim

“…Mitochondrial dysfunction has been reported in both familial and sporadic Parkinson’s disease (PD). However, effective therapy targeting this pathway is…”
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PINK1-Dependent Recruitment of Parkin to Mitochondria in Mitophagy by Vives-Bauza, Cristofol, Zhou, Chun, Huang, Yong, Cui, Mei, de Vries, Rosa L. A., Kim, Jiho, May, Jessica, Tocilescu, Maja Aleksandra, Liu, Wencheng, Ko, Han Seok, Magrané, Jordi, Moore, Darren J., Dawson, Valina L., Grailhe, Regis, Dawson, Ted M., Li, Chenjian, Tieu, Kim, Przedborski, Serge, Snyder, Solomon H.

“…Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) and PARK2/Parkin mutations cause autosomal recessive forms of Parkinson's disease. Upon…”
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Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Microglia from APOE Targeted Replacement Mice by Mhatre-Winters, Isha, Eid, Aseel, Han, Yoonhee, Tieu, Kim, Richardson, Jason R

“…The sex and APOE4 genotype are significant risk factors for Alzheimer’s disease (AD); however, the mechanism(s) responsible for this interaction are still a…”
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Mitochondria: A Common Target for Genetic Mutations and Environmental Toxicants in Parkinson's Disease by Helley, Martin P, Pinnell, Jennifer, Sportelli, Carolina, Tieu, Kim

“…Parkinson's disease (PD) is a devastating neurological movement disorder. Since its first discovery 200 years ago, genetic and environmental factors have been…”
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Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3 by Rappold, Phillip M, Cui, Mei, Chesser, Adrianne S, Tibbett, Jacqueline, Grima, Jonathan C, Duan, Lihua, Sen, Namita, Javitch, Jonathan A, Tieu, Kim

“…The herbicide paraquat (PQ) has increasingly been reported in epidemiological studies to enhance the risk of developing Parkinson's disease (PD). Furthermore,…”
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Metabolic reprogramming, oxidative stress, and pulmonary hypertension by Pokharel, Marissa D., Marciano, David P., Fu, Panfeng, Franco, Maria Clara, Unwalla, Hoshang, Tieu, Kim, Fineman, Jeffrey R., Wang, Ting, Black, Stephen M.

“…Mitochondria are highly dynamic organelles essential for cell metabolism, growth, and function. It is becoming increasingly clear that endothelial cell…”
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Exosome release and neuropathology induced by α-synuclein: new insights into protective mechanisms of Drp1 inhibition by Fan, Rebecca Z, Guo, Min, Luo, Shouqing, Cui, Mei, Tieu, Kim

“…Targeting alpha-synuclein (α-syn) as a therapeutic strategy for Parkinson's disease (PD) has been intensively pursued largely due to its well-recognized…”
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Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Astrocytes from Humanized Targeted Replacement Mice by Mhatre-Winters, Isha, Eid, Aseel, Han, Yoonhee, Tieu, Kim, Richardson, Jason R.

“…Apolipoprotein E4 (APOE4) genotype and sex are significant risk factors for Alzheimer's disease (AD), with females demonstrating increased risk modulated by…”
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organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway by Cui, Mei, Aras, Radha, Christian, Whitney V, Rappold, Phillip M, Hatwar, Mamata, Panza, Joseph, Jackson-Lewis, Vernice, Javitch, Jonathan A, Ballatori, Nazzareno, Przedborski, Serge, Tieu, Kim

“…Toxic organic cations can damage nigrostriatal dopaminergic pathways as seen in most parkinsonian syndromes and in some cases of illicit drug exposure. Here,…”
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Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin by Jin, Youngnam N, Yu, Yanxun V, Gundemir, Soner, Jo, Chulman, Cui, Mei, Tieu, Kim, Johnson, Gail V W

“…Huntington disease (HD) is an inherited neurodegenerative disease resulting from an abnormal expansion of polyglutamine in huntingtin (Htt). Compromised…”
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A partial Drp1 knockout improves autophagy flux independent of mitochondrial function by Fan, Rebecca Z, Sportelli, Carolina, Lai, Yanhao, Salehe, Said S, Pinnell, Jennifer R, Brown, Harry J, Richardson, Jason R, Luo, Shouqing, Tieu, Kim

“…Dynamin-related protein 1 (Drp1) plays a critical role in mitochondrial dynamics. Partial inhibition of this protein is protective in experimental models of…”
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D-β-hydroxybutyrate is protective in mouse models of Huntington's disease by Lim, Soyeon, Chesser, Adrianne S, Grima, Jonathan C, Rappold, Phillip M, Blum, David, Przedborski, Serge, Tieu, Kim

“…Abnormalities in mitochondrial function and epigenetic regulation are thought to be instrumental in Huntington's disease (HD), a fatal genetic disorder caused…”
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Complex I Deficiency Primes Bax-Dependent Neuronal Apoptosis through Mitochondrial Oxidative Damage by Celine Perier, Tieu, Kim, Guégan, Christelle, Caspersen, Casper, Jackson-Lewis, Vernice, Valerio Carelli, Martinuzzi, Andrea, Hirano, Michio, Przedborski, Serge, Vila, Miquel

“…Dysfunction of mitochondrial complex I is a feature of human neurodegenerative diseases such as Leber hereditary optic neuropathy and Parkinson's disease. This…”
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Loss of SOX18/CLAUDIN5 disrupts the pulmonary endothelial barrier in ventilator-induced lung injury by Garcia-Flores, Alejandro E, Gross, Christine M, Zemskov, Evgeny A, Lu, Qing, Tieu, Kim, Wang, Ting, Black, Stephen M

“…Mechanical strain contributes to ventilator-induced lung injury (VILI) through multi-factorial and complex mechanisms that remain unresolved. Prevailing…”
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