Search Results - "Tietz, Jonathan I"

In Vitro Biosynthesis of the Core Scaffold of the Thiopeptide Thiomuracin by Hudson, Graham A, Zhang, Zhengan, Tietz, Jonathan I, Mitchell, Douglas A, van der Donk, Wilfred A

“…Thiopeptides are potent antibiotics that inhibit protein synthesis. They are made by a remarkable post-translational modification process that transforms a…”
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Using Genomics for Natural Product Structure Elucidation by Tietz, Jonathan I, Mitchell, Douglas A

“…Natural products (NPs) are the most historically bountiful source of chemical matter for drug development-especially for anti-infectives. With insights gleaned…”
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Biosynthetic Timing and Substrate Specificity for the Thiopeptide Thiomuracin by Zhang, Zhengan, Hudson, Graham A, Mahanta, Nilkamal, Tietz, Jonathan I, van der Donk, Wilfred A, Mitchell, Douglas A

“…The biosynthesis of the thiopeptide thiomuracin is a well-orchestrated process involving a multitude of posttranslational modifications. We show that six Cys…”
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The "Broadest Reasonable Interpretation" and Applying Issue Preclusion to Administrative Patent Claim Construction by Tietz, Jonathan I.

“…Inventions are tangible. Yet patents comprise words, and words are imprecise. Thus, disputes over patents involve a process known as "claim construction" which…”
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A new genome-mining tool redefines the lasso peptide biosynthetic landscape by Tietz, Jonathan I, Schwalen, Christopher J, Patel, Parth S, Maxson, Tucker, Blair, Patricia M, Tai, Hua-Chia, Zakai, Uzma I, Mitchell, Douglas A

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On Lawyers and Copy Editors by Tietz, Jonathan I.

“…"I have nothing against rules" (p. 6)-a counterintuitive qualifier in an ostensibly prescriptive book on stylistic minutiae, grammar, commas, usage, and…”
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Identification of an Auxiliary Leader Peptide-Binding Protein Required for Azoline Formation in Ribosomal Natural Products by Dunbar, Kyle L, Tietz, Jonathan I, Cox, Courtney L, Burkhart, Brandon J, Mitchell, Douglas A

“…Thiazole/oxazole-modified microcins (TOMMs) are a class of post-translationally modified peptide natural products bearing azole and azoline heterocycles. The…”
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Nucleophilic 1,4-Additions for Natural Product Discovery by Cox, Courtney L, Tietz, Jonathan I, Sokolowski, Karol, Melby, Joel O, Doroghazi, James R, Mitchell, Douglas A

“…Natural products remain an important source of drug candidates, but the difficulties inherent to traditional isolation, coupled with unacceptably high rates of…”
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In Vitro Biosynthesis and Substrate Tolerance of the Plantazolicin Family of Natural Products by Deane, Caitlin D, Burkhart, Brandon J, Blair, Patricia M, Tietz, Jonathan I, Lin, Alice, Mitchell, Douglas A

“…Plantazolicin (PZN) is a ribosomally synthesized and post-translationally modified peptide (RiPP) natural product that exhibits extraordinarily narrow-spectrum…”
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A new genome-mining tool redefines the lasso peptide biosynthetic landscape by Tietz, Jonathan I, Schwalen, Christopher J, Patel, Parth S, Maxson, Tucker, Blair, Patricia M, Tai, Hua-Chia, Zakai, Uzma I, Mitchell, Douglas A

“…RODEO, an algorithm developed for RiPP natural product discovery, was applied to map out the gene clusters that encode and tailor lasso peptides and led to the…”
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Targeting Reactive Carbonyls for Identifying Natural Products and Their Biosynthetic Origins by Maxson, Tucker, Tietz, Jonathan I, Hudson, Graham A, Guo, Xiao Rui, Tai, Hua-Chia, Mitchell, Douglas A

“…Natural products (NPs) serve important roles as drug candidates and as tools for chemical biology. However, traditional NP discovery, largely based on…”
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Structure, Bioactivity, and Resistance Mechanism of Streptomonomicin, an Unusual Lasso Peptide from an Understudied Halophilic Actinomycete by Metelev, Mikhail, Tietz, Jonathan I., Melby, Joel O., Blair, Patricia M., Zhu, Lingyang, Livnat, Itamar, Severinov, Konstantin, Mitchell, Douglas A.

“…Natural products are the most historically significant source of compounds for drug development. However, unacceptably high rates of compound rediscovery…”
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Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products by Molloy, Evelyn M., Tietz, Jonathan I., Blair, Patricia M., Mitchell, Douglas A.

“…[Display omitted] The hygrolides, a family of 16-member-ring-containing plecomacrolides produced by Actinobacteria, exhibit numerous reported bioactivities…”
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Preparation of Brominated 2‑Alkoxythiophenes via Oxidation and Etherification of 2‑Thienyltrifluoroborate Salts by Tietz, Jonathan I, Seed, Alexander J, Sampson, Paul

“…The synthesis of ring brominated long-chain 2-alkoxythiophenes is reported, involving mild (Oxone) oxidation of readily prepared 2-thienyltrifluoroborate salts…”
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Low molar mass thieno[3,2-b] and thieno[2,3-b]thiophenes in liquid crystal materials science: recent synthetic approaches by Seed, Alexander J., Tietz, Jonathan I., Gipson, Raymond M., Yu, Yong, Sampson, Paul

“…One of us (AJS) was fortunate enough to have known Professor George Gray during his final years of teaching at the University of Hull. In 1989, I was finishing…”
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Novel 5-(4-alkoxyphenyl)thieno[3,2-b]thiophene-2-carboxylate esters: Highly efficient synthesis and mesogenic evaluation of a new class of materials exhibiting the smectic C phase by Tietz, Jonathan I., Mastriana, James R., Sampson, Paul, Seed, Alexander J.

“…A series of alkyl 5-(4-alkoxyphenyl)thieno[3,2-b]thiophene-2-carboxylates were prepared via a direct, efficient Pd(0)-catalysed Suzuki-Miyaura coupling…”
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Novel 5-(4-alkoxyphenyl)thieno[3,2-b]thiophene-2-carboxy late esters: Highly efficient synthesis and mesogenic evaluation of a new class of materials exhibiting the smectic C phase by Tietz, Jonathan I, Mastriana, James R, Sampson, Paul, Seed, Alexander J

“…A series of alkyl 5-(4-alkoxyphenyl)thieno[3,2-b]thiophene-2-carboxy lates were prepared via a direct, efficient Pd(0)-catalysed Suzuki-Miyaura coupling…”
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